Weight Control System

Weight Control System, a set of linked computer programs which provides weight and balance reports from magnetic tape files, provides weight control and reporting on launch vehicle programs. With minor format modifications the program is applicable to aerospace, marine, automotive and other land transportation industries

Optimization of the neutron yield in fusion plasmas produced by Coulomb explosions of deuterium clusters irradiated by a petawatt laser

The kinetic energy of hot (multi-keV) ions from the laser-driven Coulomb explosion of deuterium clusters and the resulting fusion yield in plasmas formed from these exploding clusters has been investigated under a variety of conditions using the Texas Petawatt laser. An optimum laser intensity was found for producing neutrons in these cluster fusion plasmas with corresponding average ion energies of 14 keV. The substantial volume (1-10 mm(3)) of the laser-cluster interaction produced by the petawatt peak power laser pulse led to a fusion yield of 1.6x10(7) neutrons in a single shot with a 120 J, 170 fs laser pulse. Possible effects of prepulses are discussed. DOI: 10.1103/PhysRevE.87.023106Glenn Focht Memorial FellowshipNNSA DE-FC52-08NA28512DOE Office of Basic Energy SciencesPhysic

A microfluidic chip based model for the study of full thickness human intestinal tissue using dual flow

© 2016 Author(s). The study of inflammatory bowel disease, including Ulcerative Colitis and Crohn's Disease, has relied largely upon the use of animal or cell culture models; neither of which can represent all aspects of the human pathophysiology. Presented herein is a dual flow microfluidic device which holds full thickness human intestinal tissue in a known orientation. The luminal and serosal sides are independently perfused ex vivo with nutrients with simultaneous waste removal for up to 72 h. The microfluidic device maintains the viability and integrity of the tissue as demonstrated through Haematoxylin & Eosin staining, immunohistochemistry and release of lactate dehydrogenase. In addition, the inflammatory state remains in the tissue after perfusion on the device as determined by measuring calprotectin levels. It is anticipated that this human model will be extremely useful for studying the biology and tes ting novel interventions in diseased tissue

Distributed Community Detection in Dynamic Graphs

Inspired by the increasing interest in self-organizing social opportunistic networks, we investigate the problem of distributed detection of unknown communities in dynamic random graphs. As a formal framework, we consider the dynamic version of the well-studied \emph{Planted Bisection Model} \sdG(n,p,q) where the node set $[n]$ of the network is partitioned into two unknown communities and, at every time step, each possible edge $(u,v)$ is active with probability $p$ if both nodes belong to the same community, while it is active with probability $q$ (with $q<<p$) otherwise. We also consider a time-Markovian generalization of this model. We propose a distributed protocol based on the popular \emph{Label Propagation Algorithm} and prove that, when the ratio $p/q$ is larger than $n^{b}$ (for an arbitrarily small constant $b>0$), the protocol finds the right "planted" partition in $O(\log n)$ time even when the snapshots of the dynamic graph are sparse and disconnected (i.e. in the case $p=\Theta(1/n)$).Comment: Version I

Boundary Terms, Variational Principles and Higher Derivative Modified Gravity

We discuss the criteria that must be satisfied by a well-posed variational principle. We clarify the role of Gibbons-Hawking-York type boundary terms in the actions of higher derivative models of gravity, such as F(R) gravity, and argue that the correct boundary terms are the naive ones obtained though the correspondence with scalar-tensor theory, despite the fact that variations of normal derivatives of the metric must be fixed on the boundary. We show in the case of F(R) gravity that these boundary terms reproduce the correct ADM energy in the hamiltonian formalism, and the correct entropy for black holes in the semi-classical approximation.Comment: 54 pages, 2 figures. Several typos corrected, references added. Version appearing in PR

On the complexity of computing the kk-restricted edge-connectivity of a graph

The \emph{$k$-restricted edge-connectivity} of a graph $G$, denoted by $\lambda_k(G)$, is defined as the minimum size of an edge set whose removal leaves exactly two connected components each containing at least $k$ vertices. This graph invariant, which can be seen as a generalization of a minimum edge-cut, has been extensively studied from a combinatorial point of view. However, very little is known about the complexity of computing $\lambda_k(G)$. Very recently, in the parameterized complexity community the notion of \emph{good edge separation} of a graph has been defined, which happens to be essentially the same as the $k$-restricted edge-connectivity. Motivated by the relevance of this invariant from both combinatorial and algorithmic points of view, in this article we initiate a systematic study of its computational complexity, with special emphasis on its parameterized complexity for several choices of the parameters. We provide a number of NP-hardness and W[1]-hardness results, as well as FPT-algorithms.Comment: 16 pages, 4 figure

Pmp27 Promotes Peroxisomal Proliferation

Peroxisomes perform many essential functions in eukaryotic cells. The weight of evidence indicates that these organelles divide by budding from preexisting peroxisomes. This process is not understood at the molecular level. Peroxisomal proliferation can be induced in Saccharomyces cerevisiae by oleate. This growth substrate is metabolized by peroxisomal enzymes. We have identified a protein, Pmp27, that promotes peroxisomal proliferation. This protein, previously termed Pmp24, was purified from peroxisomal membranes, and the corresponding gene, PMP27, was isolated and sequenced. Prop27 shares sequence similarity with the Pmp30 family in Candida boidinii. Pmp27 is a hydrophobic peroxisomal membrane protein but it can be extracted by high pH, suggesting that it does not fully span the bilayer. Its expression is regulated by oleate. The function of Pmp27 was probed by observing the phenotype of strains in which the protein was eliminated by gene disruption or overproduced by expression from a multicopy plasmid. The strain containing the disruption (3B) was able to grow on all carbon sources tested, including oleate, although growth on oleate, glycerol, and acetate was slower than wild type. Strain 3B contained peroxisomes with all of the enzymes of β-oxidation. However, in addition to the presence of a few modestly sized peroxisomes seen in a typical thin section of a cell growing on oleate-containing medium, cells of strain 3B also contained one or two very large peroxisomes. In contrast, cells in a strain in which Pmp27 was overexpressed contained an increased number of normal-sized peroxisomes. We suggest that Pmp27 promotes peroxisomal proliferation by participating in peroxisomal elongation or fission.

The Texas Petawatt Laser And Current Experiments

The Texas Petawatt Laser is operational with experimental campaigns executed in both F/40 and F3 target chambers. Recent improvements have resulted in intensities of >2x10(21) W/cm(2) on target. Experimental highlights include, accelerated electron energies of >2 GeV, DD fusion ion temperatures >25 keV and isochorically heated solids to 10-50 eV.Physic

Fine Structures of Shock of SN 1006 with the Chandra Observation

The north east shell of SN 1006 is the most probable acceleration site of high energy electrons (up to ~ 100 TeV) with the Fermi acceleration mechanism at the shock front. We resolved non-thermal filaments from thermal emission in the shell with the excellent spatial resolution of Chandra. The thermal component is extended widely over about ~ 100 arcsec (about 1 pc at 1.8 kpc distance) in width, consistent with the shock width derived from the Sedov solution. The spectrum is fitted with a thin thermal plasma of kT = 0.24 keV in non-equilibrium ionization (NEI), typical for a young SNR. The non-thermal filaments are likely thin sheets with the scale widths of ~ 4 arcsec (0.04 pc) and ~ 20 arcsec (0.2 pc) at upstream and downstream, respectively. The spectra of the filaments are fitted with a power-law function of index 2.1--2.3, with no significant variation from position to position. In a standard diffusive shock acceleration (DSA) model, the extremely small scale length in upstream requires the magnetic field nearly perpendicular to the shock normal. The injection efficiency (eta) from thermal to non-thermal electrons around the shock front is estimated to be ~ 1e-3 under the assumption that the magnetic field in upstream is 10 micro G. In the filaments, the energy densities of the magnetic field and non-thermal electrons are similar to each other, and both are slightly smaller than that of thermal electrons. in the same order for each other. These results suggest that the acceleration occur in more compact region with larger efficiency than previous studies.Comment: 24 pages, 11 figures, Accepted for publication in ApJ, the paper with full resolution images in http://www-cr.scphys.kyoto-u.ac.jp/member/bamba/Paper/SN1006.pd