20 research outputs found

    Exploiting magnification bias in ultradeep submillimetre-wave surveys using ALMA

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    The surface density of populations of galaxies with steep/shallow source counts is increased/decreased by gravitational lensing magnification. These effects are usually called `magnification bias' and `depletion' respectively. However, if sources are demagnified by lensing, then the situation is reversed, and the detectable surface density of galaxies with a shallow source count, as expected at the faintest flux densities, is increased. In general, demagnified sources are difficult to detect and study: exquisite subarcsecond angular resolution and surface brightness sensitivity are required, and emission from the lensing object must not dominate the image. These unusual conditions are expected to be satisfied for observations of the dense swarm of demagnified images that could form very close to the line of sight through the centre of a rich cluster of galaxies using the forthcoming submillimetre-wave Atacama Large Millimeter Array (ALMA) interferometer. The demagnified images of most of the background galaes lying within about 1 arcmin of a rich cluster of galaxies could be detected in a single 18-arcsec-diameter ALMA field centred on the cluster core, providing an effective increase in the ALMA field of view. This technique could allow a representative sample of faint, 10-100 microJy submillimetre galaxies to be detected several times more rapidly than in a blank field.Comment: 6 pages, 2 figures, MNRAS in pres

    Toward an internally consistent astronomical distance scale

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    Accurate astronomical distance determination is crucial for all fields in astrophysics, from Galactic to cosmological scales. Despite, or perhaps because of, significant efforts to determine accurate distances, using a wide range of methods, tracers, and techniques, an internally consistent astronomical distance framework has not yet been established. We review current efforts to homogenize the Local Group's distance framework, with particular emphasis on the potential of RR Lyrae stars as distance indicators, and attempt to extend this in an internally consistent manner to cosmological distances. Calibration based on Type Ia supernovae and distance determinations based on gravitational lensing represent particularly promising approaches. We provide a positive outlook to improvements to the status quo expected from future surveys, missions, and facilities. Astronomical distance determination has clearly reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press (chapter 8 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

    Endostatin modulates VEGF-mediated barrier dysfunction in the retinal microvascular endothelium

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    Recent evidence indicates that the anti-angiogenic peptide endostatin may modulate some of the vasomodulatory effects of vascular endothelial growth factor (VEGF) in the retina, including reduction of blood retinal barrier function although it remains uncertain how endostatin promotes endothelial barrier properties. The current study has sought to examine how physiological levels of endostatin alters VEGF-induced inner BRB function using an in vitro model system and evaluation of occludin and ZO-1 regulatory responses. In addition, the ability of exogenous endostatin to regulate VEGF-mediated retinal vascular permeability in vivo was investigated. Retinal microvascular endothelial cells (RMEC's) were exposed to various concentrations of endostatin. In parallel studies, RMEC monolayers were treated with vascular endothelial growth factor (VEGF₁₆₅). Vasopermeability of RMEC monolayers and occludin expression were determined. Blood retinal barrier integrity was quantified in mouse retina using Evans Blue assay following intravitreal delivery of VEGF₁₆₅, endostatin or a VEGF/endostatin combination. Endostatin increased the levels of expression of occludin whilst causing no significant change in FITC-dextran flux across the RMEC monolayer. Endostatin reversed the effects of VEGF₁₆₅-enhanced permeability between microvascular endothelial cells and induced phosphorylation of occludin. Evans Blue leakage from retinas treated with VEGF was 2.0 fold higher than that of contra-lateral untreated eyes (P<0.05) while leakage of eyes from endostatin treated animals was unchanged. When eyes were injected with a combination of VEGF₁₆₅ and endostatin there was a significant reduction in retinal vasopermeability when compared to VEGF-injected eyes (P<0.05). We conclude that endostatin can promote integrity of the retinal endothelial barrier, possibly by preventing VEGF-mediated alteration of tight junction integrity. This suggests that endostatin may be of clinical benefit in ocular disorders where significant retinal vasopermeability changes are present.10 page(s

    Mid-infrared spectroscopy of candidate active galactic nuclei-dominated submillimeter galaxies

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    Spitzer spectroscopy has revealed that sime80% of submm galaxies (SMGs) are starburst (SB)-dominated in the mid-infrared. Here we focus on the remaining sime20% that show signs of harboring powerful active galactic nuclei (AGNs). We have obtained Spitzer-InfraRed Spectrograph spectroscopy of a sample of eight SMGs that are candidates for harboring powerful AGNs on the basis of IRAC color selection (S 8 μm/S 4.5 μm>2, i.e., likely power-law mid-infrared spectral energy distributions). SMGs with an AGN dominating (gsim50%) their mid-infrared emission could represent the "missing link" sources in an evolutionary sequence involving a major merger. First of all, we detect polycyclic aromatic hydrocarbon (PAH) features in all of the SMGs, indicating redshifts from 2.5 to 3.4, demonstrating the power of the mid-infrared to determine redshifts for these optically faint dusty galaxies. Second, we see signs of both star formation (from the PAH features) and AGN activity (from continuum emission) in our sample: 62% of the sample are AGN-dominated in the mid-infrared with a median AGN content of 56%, compared with 1.65 works well at selecting mid-infrared energetically dominant AGNs in SMGs, implying a duty cycle of ~15% if all SMGs go through a subsequent mid-infrared AGN-dominated phase in the proposed evolutionary sequence

    Galaxy and Mass Assembly: FUV, NUV, ugrizYJHK Petrosian, Kron and Sérsic photometry

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    In order to generate credible 0.1-2 {\mu}m SEDs, the GAMA project requires many Gigabytes of imaging data from a number of instruments to be re-processed into a standard format. In this paper we discuss the software infrastructure we use, and create self-consistent ugrizYJHK photometry for all sources within the GAMA sample. Using UKIDSS and SDSS archive data, we outline the pre-processing necessary to standardise all images to a common zeropoint, the steps taken to correct for seeing bias across the dataset, and the creation of Gigapixel-scale mosaics of the three 4x12 deg GAMA regions in each filter. From these mosaics, we extract source catalogues for the GAMA regions using elliptical Kron and Petrosian matched apertures. We also calculate S\'ersic magnitudes for all galaxies within the GAMA sample using SIGMA, a galaxy component modelling wrapper for GALFIT 3. We compare the resultant photometry directly, and also calculate the r band galaxy LF for all photometric datasets to highlight the uncertainty introduced by the photometric method. We find that (1) Changing the object detection threshold has a minor effect on the best-fitting Schechter parameters of the overall population (M* +/- 0.055mag, {\alpha} +/- 0.014, {\Phi}* +/- 0.0005 h^3 Mpc^{-3}). (2) An offset between datasets that use Kron or Petrosian photometry regardless of the filter. (3) The decision to use circular or elliptical apertures causes an offset in M* of 0.20mag. (4) The best-fitting Schechter parameters from total-magnitude photometric systems (such as SDSS modelmag or S\'ersic magnitudes) have a steeper faint-end slope than photometry dependent on Kron or Petrosian magnitudes. (5) Our Universe's total luminosity density, when calculated using Kron or Petrosian r-band photometry, is underestimated by at least 15%
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