Mitochondrial/Nuclear Transfer: A Literature Review of the Ethical, Legal and Social Issues

Mitochondrial/nuclear transfer (M/NT) to avoid the transmission of serious mitochondrial disease raises complex and challenging ethical, legal and social issues (ELSI). In February 2015, the United Kingdom became the first country in the world to legalize M/NT, making the heated debate surrounding this technology even more relevant. This critical interpretive review identified 95 relevant papers discussing the ELSI of M/NT, including original research articles, government-commissioned reports, editorials, letters to editors and research news. The review presents and synthesizes the arguments present in the literature in relation to the most commonly raised themes: terminology; identity, relationships and parenthood; potential harm; reproductive autonomy; available alternatives; consent; impact on specific interest groups; resources; “slippery slope”; creation, use and destruction of human embryos; and beneficence. The review concludes by identifying those ELSI that are specific to M/NT and by calling for follow-up longitudinal clinical and psychosocial research in order to equip future ELSI debate with empirical evidence

Mitochondrial/Nuclear Transfer: A Literature Review of the Ethical, Legal and Social Issues

Mitochondrial/nuclear transfer (M/NT) to avoid the transmission of serious mitochondrial disease raises complex and challenging ethical, legal and social issues (ELSI). In February 2015, the United Kingdom became the first country in the world to legalize M/NT, making the heated debate surrounding this technology even more relevant. This critical interpretive review identified 95 relevant papers discussing the ELSI of M/NT, including original research articles, government-commissioned reports, editorials, letters to editors and research news. The review presents and synthesizes the arguments present in the literature in relation to the most commonly raised themes: terminology; identity, relationships and parenthood; potential harm; reproductive autonomy; available alternatives; consent; impact on specific interest groups; resources; “slippery slope”; creation, use and destruction of human embryos; and beneficence. The review concludes by identifying those ELSI that are specific to M/NT and by calling for follow-up longitudinal clinical and psychosocial research in order to equip future ELSI debate with empirical evidence.Le transfert mitochondrial / nucléaire (M/NT) visant à éviter la transmission de maladies mitochondriales graves soulève des enjeux éthiques, juridiques et sociaux (ELS) complexes. En février 2015, le Royaume-Uni est devenu le premier pays au monde à légaliser le M/NT, rendant le débat houleux sur cette technologie encore plus pertinent. Cette revue d’interprétation critique identifie 95 articles pertinents sur les enjeux ELS du M/NT, y compris des articles de recherche originaux, des rapports gouvernementaux ou commandés par le gouvernement, des éditoriaux, des lettres aux éditeurs et des nouvelles de recherche. La revue présente et synthétise les arguments présents dans la littérature quant aux thèmes les plus fréquemment soulevés: terminologie; identité, relations et parentalité; dommage potentiel; autonomie reproductive; alternatives disponibles; consentement; impact sur des groupes d’intérêt spécifiques; ressources; « pente glissante »; création, utilisation et destruction des embryons humains; et bienfaisance. La revue conclut en identifiant les enjeux ELS spécifiques au M/NT et en appelant à une recherche de suivi longitudinale clinique et psychosociale afin d’alimenter le futur débat sur les enjeux ELS de preuves empiriques

Proceedings of the 4th World Conference on Research Integrity

CITATION: O’Brien, S. P., et al. 2016. Proceedings of the 4th World Conference on Research Integrity. Research Integrity and Peer Review, 1:9, doi:10.1186/s41073-016-0012-9.The original publication is available at https://researchintegrityjournal.biomedcentral.comThese Proceedings contain the abstracts of the presentations given at the 4th World Conference in concurrent sessions, partner symposia, and poster sessions. Also included are summaries of the discussions in three focus tracks, which allowed delegates to consider and work on questions about the roles of funders, institutions, and countries in improving research systems and strengthening research integrity. Videos of the plenary presentations are available at the conference website (www.wcri2015.org).https://researchintegrityjournal.biomedcentral.com/articles/10.1186/s41073-016-0012-