Implementing a Data Publishing Service via DSpace

4th International Conference on Open RepositoriesThis presentation was part of the session : DSpace User Group PresentationsDate: 2009-05-20 01:30 PM – 03:00 PMThe Indiana University Libraries and Digital Library Program offer a set of online scholarly communication services to IU scholars under the brand IUScholarWorks. Currently, these services include IUScholarWorks Repository, a DSpace-based institutional repository for dissemination and preservation of articles, papers, technical reports, and other scholarly products, and IUScholarWorks Journals, an Open Journal System-based online journal hosting service. To complement these two existing services, the Libraries and Digital Library Program are collaborating with the Research Technologies division of IU's central IT organization to implement a research data publishing service as a new feature of IUScholarWorks Repository. The idea of this service is to allow researchers to easily publish their datasets for online access at a stable web address, reference these datasets from publications, and assume at least bit-level preservation of the data. The intent is to develop a service that is generic enough to be used for everything from sensor data to statistical data to ethnographic field video. This service will leverage IU's existing Massive Data Storage System, which is an existing large scale centrally-funded distributed storage service offered by Research Technologies to IU faculty, staff, and graduate students for storage of their research data. Based on the consortium-developed High Performance Storage System (HPSS) software, MDSS offers over 2.8 petabytes of disk- and tape-based storage distributed between IU's Bloomington and Indianapolis campuses and supports replication of data between these two sites. Data may be transferred in and out of MDSS using a variety of interfaces, including SFTP, Parallel FTP, GridFTP, HSI, SMB/CIFS, and a simple Web-based user interface. We intend to initially support two data publishing scenarios: One in which a researcher submits a dataset by entering minimal metadata and uploading data files through DSpace's Configurable Submission Interface (which are then automatically placed in MDSS if they are over a specified filesize), and the other in which the researcher indicates as part of the submission process that the data to be published already resides in a personal or research group account in MDSS and should be copied into an IUScholarWorks-managed area of MDSS for availability through DSpace. In this presentation, we will discuss our conception of the service, its technical architecture and design, metadata requirements, and progress on implementation. We will also discuss the potential applicability of our approach and implementation to others who are interested in implementing similar services

Combined effects of increased water temperature and cyanobacterial compounds exert heterogeneous effects on survival and ecological processes in key freshwater species

Climate change is increasing water temperature and intensifying the incidence of cyanobacterial blooms worldwide. However, the combined effects of increased temperature and microcystin concentrations as co-stressors on survival and ecological processes in freshwater species are unclear. Here, using purified MC-LR and crude extract of toxigenic Microcystis aeruginosa, we tested the individual and combined effects of three water temperatures (15, 20, 25 °C) and a range of environmentally relevant concentrations of dissolved microcystin and crude extract (0.01–10 µg·L−1) on survival, growth inhibition, grazing and predation rates in three freshwater species: phytoplankton (Scenedesmus quadricauda), zooplankton (Daphnia pulex), and an invertebrate predator (Ischnura elegans). Purified MC-LR exerted a higher growth inhibitory effect on S. quadricauda compared to crude extract with the same concentration of MC-LR, while neither treatment affected its chlorophyll-a content or survival of D. pulex. Crude extract reduced grazing and survival of D. pulex and I. elegans, respectively. The combined effect of higher temperature and crude extract reduced I. elegans survival by 50%. Increased temperature reduced prey handing time in I. elegans by 49%, suggesting a higher predation rate. However, warming together with higher concentrations of crude extract jointly increased zooplankton grazing and reduced damselfly predation. Taken together, these results suggest crude extract, and not necessarily microcystin, can affect survival and productivity in freshwater species, although these effects may vary unevenly across trophic levels. Our findings highlight the importance of complex ecological mechanisms by which warming can exacerbate toxic effects of cyanobacterial bloom extracts on survival and functions among species in eutrophic freshwaters

Is the Autism Treatment Evaluation Checklist a useful tool for monitoring progress in children with autism spectrum disorders?

10.1111/j.1365-2788.2010.01359.xJournal of Intellectual Disability Research553302-312JIDR

Alcohol expectancies in childhood: Change with the onset of drinking and ability to predict adolescent drunkenness and binge drinking

Aims: Childhood expectancies about alcohol are present long before drinking begins. We examined the relationship between alcohol expectancies in childhood and onset of drinking, binge drinking, and drunkenness in adolescence and the influence of drinking onset on development of alcohol expectancies. Design: A prospective, longitudinal study of children assessed for alcohol expectancies and drinking at 4 time points between ages 6 and 17. Setting: Community study of families at high risk for alcoholism conducted in a 4-county area in the Midwest. Participants: The study involved 614 children; 460 were children of alcoholics and 70% were male. Measurements: Expectancies about effects of alcohol were measured using the Beverage Opinion Questionnaire and child’s drinking was measured using the Drinking and Drug History - Youth Form. Findings: Partial factor invariance was found for expectancy factors from age 6 to age 17. Survival analysis showed that social/relaxation expectancies in childhood predicted time to onset of binge drinking and first time drunk (Wald chi-square, 1 d.f. = 3.8, p < .05 and 5.1, p < .05, respectively). The reciprocal effect was also present; when adolescents began drinking, there was an increase in social/relaxation expectancy and a concomitant increase in slope of the expectancy change lasting throughout adolescence. Conclusions: A reciprocal relationship exists between childhood alcohol expectancies and involvement with alcohol. Higher expectancies for positive effects predict earlier onset of problem drinking. Onset of use, in turn, predicts an increase in rate of development of positive expectancies.NIH R37 AA07065 K01AA016591Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110697/1/Jester alcohol expectancies.pdfDescription of Jester alcohol expectancies.pdf : Main articl

Basalt-trachybasalt samples in Gale Crater, Mars

The ChemCam instrument on the Mars Science Laboratory (MSL) rover, Curiosity, observed numerous igneous float rocks and conglomerate clasts, reported previously. A new statistical analysis of single-laser-shot spectra of igneous targets observed by ChemCam shows a strong peak at ~55 wt% SiO2 and 6 wt% total alkalis, with a minor secondary maximum at 47–51 wt% SiO2 and lower alkali content. The centers of these distributions, together with the rock textures, indicate that many of the ChemCam igneous targets are trachybasalts, Mg#=27 but with a secondary concentration of basaltic material,with a focus of compositions around Mg#=54. We suggest that all of these igneous rocks resulted from low-pressure, olivine-dominated fractionation of Adirondack (MER) class-type basalt compositions. This magmatism has subalkaline, tholeiitic affinities. The similarity of the basalt endmember to much of the Gale sediment compositions in the first 1000 sols of the MSL mission suggests that this type of Fe-rich, relatively low-Mg#, olivine tholeiite is the dominant constituent of the Gale catchment that is the source material for the fine-grained sediments in Gale. The similarity to many Gusev igneous compositions suggests that it is a major constituent of ancient Martian magmas, and distinct from the shergottite parental melts thought to be associated with Tharsis and the Northern Lowlands. The Gale Crater catchment sampled a mixture of this tholeiitic basalt along with alkaline igneous material, together giving some analogies to terrestrial intraplate magmatic provinces

Social support is associated with blood pressure responses in parents caring for children with developmental disabilities

peer-reviewedThe present study tested whether parents caring for children with developmental disabilities would have higher blood pressure compared to parents of typically developing children (controls). It also examined the psychosocial factors underlying this observation. Thirty-five parents of children with developmental disability and thirty controls completed standard measures of perceived stress, child challenging behaviours and social support and wore an ambulatory blood pressure (BP) monitor throughout the day, for one day. Relative to controls, parents caring for children with developmental disabilities reported poorer psychosocial functioning and had a higher mean systolic BP. Of, the psychosocial predictors, only social support was found to be predictive. Moreover, variations in social support accounted for some of the between group differences with the 13 for parental group attenuated from .42 to .34 in regression analyses. It appears that social support may influence blood pressure responses in parental caregivers. Finally, our findings underscore the importance of providing psychosocial interventions to improve the health of family caregivers. (C) 2012 Elsevier Ltd. All rights reserved.ACCEPTEDpeer-reviewe

Actionable Patient Safety Solutions (APSS) #6: Hand-off Communications

Hand-off communications, or hand-off processes, involve the transition of care as well as the transfer of patient-specific information by one healthcare professional to another with the purpose of providing a patient with safe, continuous care. A successful hand-off can only be achieved by effective communication

A three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes

Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults, characterized by aggressive growth, limited response to therapy, and inexorable recurrence. Because of the extremely unfavorable prognosis of GBM, it is important to develop more effective diagnostic and therapeutic strategies based on biologically and clinically relevant patient stratification systems. Analyzing a collection of patient-derived GBM stem-like cells (GSCs) by gene expression profiling, nuclear magnetic resonance (NMR) spectroscopy and signal transduction pathway activation, we identified two GSC clusters characterized by different clinical features. Due to the widely documented role played by microRNAs (miRNAs) in the tumorigenesis process, in this study we explored whether these two GBM patient subtypes could also be discriminated by different miRNA signatures. Global miRNA expression pattern was analyzed by oblique principal component (OPC) analysis and principal component analysis (PCA). By a combined inferential strategy on PCA results, we identified a reduced set of three miRNAs - miR-23a, miR-27a and miR-9* (miR-9-3p) - able to discriminate the proneural- and mesenchymal-like GSC phenotypes as well as mesenchymal and proneural subtypes of primary GBM included in The Cancer Genome Atlas (TCGA) dataset. Kaplan-Meier analysis showed a significant correlation between the selected miRNAs and overall survival in 429 GBM specimens from TCGA-identifying patients who had an unfavorable outcome. The survival prognostic capability of the three miRNA signatures could have important implications for the understanding of the biology of GBM subtypes and could be useful in patient stratification to facilitate interpretation of results from clinical trials