Recasting the dynamics of post-acquisition integration:an embeddedness perspective

M&A scholars have generally assumed that post-acquisition integration is a self-contained process. However this ignores that this process rarely unfolds as the only ongoing initiative in an organization. We contend that post-acquisition integration is not detached from other simultaneous change processes in the organizational context and this has important implications for our understanding of how integration dynamics actually evolve. To further understand this embeddedness we examine the unfolding of a post-acquisition integration process in a company faced with an unanticipated drop in demand due to the global economic crisis. Through a qualitative, longitudinal study conducted over three years, we carried out 151 interviews to uncover the unfolding of the post-acquisition process. We find that post-acquisition integration is embedded in a set of co-evolving processes. We highlight four mechanisms (coordination, cohesion, disconnection, alienation) that arise from the co-evolution of processes that either facilitate or impede integration. Our findings contribute to our understanding of post-acquisition integration dynamics by recasting the integration process as embedded in a set of co-evolving processes that shape its unfolding

Priapism After Epidural or Spinal Anesthesia

Introduction: Preoperative epidural and spinal anesthesia improves patient outcomes by reducing potential side effects due to prolonged treatment with general anesthesia as well as mitigating postoperative pain. Rarely, patients receiving epidural and spinal anesthesia develop priapism secondary to administration of the anesthetic agent. Little is known about the development of this complication and its management following onset. Rationale: A case of priapism following administration of epidural anesthesia in Kalamazoo, MI, at Bronson Methodist Hospital, prompted a search of the literature into the etiology, pathophysiology, and management of such cases. Review of Literature: A search of two databases was conducted, including keywords “priapism, anesthesia, epidural, humans” among others. This search produced 305 unique articles. Priapism cases due to underlying conditions, such as sickle cell anemia, were excluded. All cases of non-spinal and non-epidural anesthesia were excluded. In total, 36 articles from the search were included in this review. Subsequently, a hand review of the selected articles produced an additional 121 new papers which are currently under review and may be included in our final review. Results: Priapism appears to be a rare complication of anesthesia, but cases are often unreported and real incidence is unknown. Overall incidence of priapism in the United States is 0.2-0.3 cases/100,000. Etiology and contribution of medical, genetic, and environmental factors are unclear. Bolus doses of bupivicaine were involved in multiple reported cases. Interestingly, epidural anesthesia can both cause and treat priapism, suggesting that pathophysiology involves an imbalance of the parasympathetic and sympathetic tone of the penile vasculature. Timing of erection onset complicates treatment of this side effect. Preoperatively, the inciting agent is generally withdrawn and the procedure is postponed until other anesthetic options are explored. Postoperatively, another anesthetic is administered for pain relief. Intraoperatively, the appropriate course of action is multifactorial, depending patient’s underlying health status and variables inherent to the procedure. No long-term adverse effects, such as erectile dysfunction or dysuria, were reported. During the episode patients experienced distress at the inability to urinate and acute pain from the prolonged erection. Conclusion: Priapism due to epidural and spinal anesthesia remains a mysterious phenomenon. Bupivicaine has been suggested as a causative agent, perhaps selectively inhibiting sympathetic tone to the penile vasculature. There are many factors to consider when treating this complication, including procedural and patient characteristics

That’s great on paper… but not in practice! – A routine ecology perspective to understand M&A integration barriers.

Building on the endogenous routine dynamic perspective, we aim to understand the micro-foundations of capability transfer in post-acquisition integration. Based on a single, longitudinal case study of an acquisition in the consultancy sector, we apply a practice-based lens to study the intended combination of two existing routines in an acquisition process and why its implementation turned out to be a failure. Our findings suggest that seemingly matching capabilities were not compatible in practice as the underlying sequences of action were incompatible and their embeddedness in its intra- and inter-organizational ecology of routines was not considered. Our article sheds light on the role of routines in acquisition integration and contributes to literature by discussing a) the prevailing role of the interconnectedness of routines in effective capability transfer and b) discrepancies between ostensive and performative aspects of routines as impediments to the implementation of the pre-acquisition plan in the post-acquisition phase

The Grizzly, September 22, 1998

Ursinus Gears Up for Family Day • Dr. Fouts Gives Lecture on Chimpanzee Research • Freshman Class Election Results • Opinion: Ursinus\u27 Movement Towards Diversity; In Response to Has America Sunk to the Level of Terrorists? • Presentations on Family Day • Help is out There • Old Dogs Don\u27t Need New Tricks • Big, Big Band: Big, Big Success • Theater Life • Field Hockey Wrap-Up • UC Volleyball Evens Out at 2-2 • Bears Recognized in Centennial Conference Honor Roll • Lady Bears Suffer Conference Losses • Men\u27s Soccer Split Games • Football Falls in Conference Opener • Flo Jo Dies at 38 • Ripken Ends Streakhttps://digitalcommons.ursinus.edu/grizzlynews/1424/thumbnail.jp

The Grizzly, September 29, 1998

Construction Begins for New Bookstore • Ursinus Students Named Smith Scholars • Econ. Students Apply Classroom Knowledge • Opinion: Terrorist Debate Continues; Ursinus Keeps up With the Times; Students Vote Two Thumbs up for Co-ed Living • Is Home the way you Left it? • Students Spending Weekends Differently • Hugs Help Pottstown Hospital • Family Day \u2798 = Success • Kelley on Photography • Berman Exhibits Not Well Attended • Volleyball Hit With Key Injury • UC Football Gets Terrorized • Men\u27s Soccer Drops Two • Women\u27s Soccer Shuts-Out Dickinson • Who\u27s in Charge Here? • Women\u27s Rugby Overpowered by Lock Haven University • Centennial Conference Newshttps://digitalcommons.ursinus.edu/grizzlynews/1425/thumbnail.jp

Bimodal dynamics of granular organelles in primary renin-expressing cells revealed using TIRF microscopy

Renin is the initiator and rate-limiting factor in the renin-angiotensin blood pressure regulation system. Although renin is not exclusively produced in the kidney, in nonmurine species the synthesis and secretion of the active circulatory enzyme is confined almost exclusively to the dense core granules of juxtaglomerular (JG) cells, where prorenin is processed and stored for release via a regulated pathway. Despite its importance, the structural organization and regulation of granules within these cells is not well understood, in part due to the difficulty in culturing primary JG cells in vitro and the lack of appropriate cell lines. We have streamlined the isolation and culture of primary renin-expressing cells suitable for high-speed, high-resolution live imaging using a Percoll gradient-based procedure to purify cells from RenGFP+ transgenic mice. Fibronectin-coated glass coverslips proved optimal for the adhesion of renin-expressing cells and facilitated live cell imaging at the plasma membrane of primary renin cells using total internal reflection fluorescence microscopy (TIRFM). To obtain quantitative data on intracellular function, we stained mixed granule and lysosome populations with Lysotracker Red and stimulated cells using 100 nM isoproterenol. Analysis of membrane-proximal acidic granular organelle dynamics and behavior within renin-expressing cells revealed the existence of two populations of granular organelles with distinct functional responses following isoproterenol stimulation. The application of high-resolution techniques for imaging JG and other specialized kidney cells provides new opportunities for investigating renal cell biology