Conservative management for urinary incontinence in neurological patients: A systematic review and meta-analysis

Aim: To summarize evidence from a search and review of the 7th International Consultation on Incontinence chapter’s section on conservative treatments in neurological patients. Methods: Searching the Cochrane Incontinence Specialised Register (MEDLINE, CENTRAL, others) on August 2nd, 2022. Quality and certainty evidence were assessed using the Cochrane Risk of Bias Tool and the Grading of Recommendations Assessment, Development and Evaluation. Results: After screening 5416 records, 40 trials with 2751 participants were included and stratified according to the site and nature of the neurological disease: (1) Brain disorders n = 22; (2) Spinal cord disorders n = 3; (3) Multiple sclerosis (MS) n = 13; (4) Mixed types of neurological diseases n = 2. Pooled analysis from trials in participants with brain disorders showed that, compared to no active treatment, electrical stimulation (EStim) improved UI episodes per day based on very low certainty evidence and improved UI symptom measures based on moderate certainty evidence. Further, compared to usual care, toilet assistance improved neurological quality of life (QoL) measures based on moderate certainty evidence. Pooled analysis from trials in participants with MS showed that, compared to pelvic floor muscle training (PFMT) alone, PFMT plus EStim was effective for improving the number of UI episodes per day based on moderate certainty evidence. Conclusion: Our review shows that neurological patients could benefit from conservative interventions to improve symptoms of UI, and QoL. Further well-designed trials with larger cohorts and longer-term follow-up are needed given the limited studies in this population

Density Matrix Renormalization Group Applied to the Ground State of the XY-Spin-Peierls System

We use the density matrix renormalization group (DMRG) to map out the ground state of a XY-spin chain coupled to dispersionless phonons of frequency $\omega$. We confirm the existence of a critical spin-phonon coupling $_c\propto \omega ^{0.7}$ for the onset of the spin gap bearing the signature of a Kosterlitz-Thouless transition. We also observe a classical-quantum crossover when the spin-Peierls gap $\Delta$ is of order $$. In the classical regime, $\Delta >\omega$, the mean-field parameters are strongly renormalized by non-adiabatic corrections. This is the first application of the DMRG to phonons.Comment: 10 pages, 5 figures. To be published in PR

Triplet Dispersion in CuGeO_3: Perturbative Analysis

We reconsider the 2d model for CuGeO_3 introduced previously (Phys. Rev. Lett. 79, 163 (1997)). Using a computer aided perturbation method based on flow equations we expand the 1-triplet dispersion up to 10th order. The expansion is provided as a polynom in the model parameters. The latter are fixed by fitting the theoretical result to experimental data obtained by INS. For a dimerization delta = 0.08(1) we find an excellent agreement with experiment. This value is at least 2 to 3 times higher than values deduced previously from 1d chain approaches. For the intrachain frustration alpha_0 we find a smaller value of 0.25(3). The existence of interchain frustration conjectured previously is confirmed by the analysis of temperature dependent susceptibility.Comment: 8 pages, 10 figures, submitted to Phys. Rev.

Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein

In a stable condition: Disulfide bonds stabilize folded proteins primarily by decreasing the entropic cost of folding. Such cross-links also reduce toxic aggregation by favoring the formation of highly structured amyloid fibrils (see picture). It is suggested that disulfide bonds in extracellular proteins were selected by evolutionary pressures because they decrease the propensity to form toxic aggregates. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

A fast and cost-effective approach to develop and map EST-SSR markers: oak as a case study

Background: Expressed Sequence Tags (ESTs) are a source of simple sequence repeats (SSRs) that can be used to develop molecular markers for genetic studies. The availability of ESTs for Quercus robur and Quercus petraea provided a unique opportunity to develop microsatellite markers to accelerate research aimed at studying adaptation of these long-lived species to their environment. As a first step toward the construction of a SSR-based linkage map of oak for quantitative trait locus (QTL) mapping, we describe the mining and survey of EST-SSRs as well as a fast and cost-effective approach (bin mapping) to assign these markers to an approximate map position. We also compared the level of polymorphism between genomic and EST-derived SSRs and address the transferability of EST-SSRs in Castanea sativa (chestnut). Results: A catalogue of 103,000 Sanger ESTs was assembled into 28,024 unigenes from which 18.6% presented one or more SSR motifs. More than 42% of these SSRs corresponded to trinucleotides. Primer pairs were designed for 748 putative unigenes. Overall 37.7% (283) were found to amplify a single polymorphic locus in a reference fullsib pedigree of Quercus robur. The usefulness of these loci for establishing a genetic map was assessed using a bin mapping approach. Bin maps were constructed for the male and female parental tree for which framework linkage maps based on AFLP markers were available. The bin set consisting of 14 highly informative offspring selected based on the number and position of crossover sites. The female and male maps comprised 44 and 37 bins, with an average bin length of 16.5 cM and 20.99 cM, respectively. A total of 256 EST-SSRs were assigned to bins and their map position was further validated by linkage mapping. EST-SSRs were found to be less polymorphic than genomic SSRs, but their transferability rate to chestnut, a phylogenetically related species to oak, was higher. Conclusion: We have generated a bin map for oak comprising 256 EST-SSRs. This resource constitutes a first step toward the establishment of a gene-based map for this genus that will facilitate the dissection of QTLs affecting complex traits of ecological importance

Dark Matter Search in the Edelweiss Experiment

Preliminary results obtained with 320g bolometers with simultaneous ionization and heat measurements are described. After a few weeks of data taking, data accumulated with one of these detectors are beginning to exclude the upper part of the DAMA region. Prospects for the present run and the second stage of the experiment, EDELWEISS-II, using an innovative reversed cryostat allowing data taking with 100 detectors, are briefly described.Comment: IDM 2000, 3rd International Workshop on the Identification of Dark Matter, York (GB), 18-22/09/2000, v2.0 minor modification

The EDELWEISS Experiment : Status and Outlook

The EDELWEISS Dark Matter search uses low-temperature Ge detectors with heat and ionisation read- out to identify nuclear recoils induced by elastic collisions with WIMPs from the galactic halo. Results from the operation of 70 g and 320 g Ge detectors in the low-background environment of the Modane Underground Laboratory (LSM) are presented.Comment: International Conference on Dark Matter in Astro and Particle Physics (Dark 2000), Heidelberg, Germany, 10-16 Jul 2000, v3 minor revision