A GIS-based hydrographic resurvey strategy of the Belgian Continental Shelf

Using a GIS-based approach, bathymetric surveys and maritime traffic records were combined to determine resurvey priorities within the Belgian Continental Shelf (BCS). Four reference layers were produced: (1) water depth; (2) maximum absolute change in water depth; (3) ship traffic intensity; (4) maximum ship draught. The reference layers were reclassified and merged into a weighted overlay analysis. Two combinations of layers and weight factors were used and resulted in priority maps differing greatly from each other. The reliability of the analysis depends on the way weight factors are assigned, and on the availability and accuracy of the data. These are limited for bathymetric surveys. This empirical GIS-based methodology can be applied as a whole to a zone showing various morphodynamic patterns. It can also be automated: additional datasets can be included in the analysis, and different scenarios and assumptions can be easily tested

Family Belongingness Attenuates Entrapment and Buffers Its Association with Suicidal Ideation in a Sample of Dutch Sexual Minority Emerging Adults

Sexual minority emerging adults are more likely to engage in suicidal ideation than their heterosexual counterparts. Experiences of homophobic violence are associated with suicidal ideation. Yet, the specific mechanisms linking homophobic violence to suicidal ideation remain unclear. Entrapment and social belongingness were tested to determine their relevance for understanding the link between homophobic violence and suicidal ideation. A sample of sexual minority Dutch emerging adults (N = 675; ages 18–29, M = 21.93 years, SD = 3.20) were recruited through online platforms and flyers. Homophobic violence was expected to be positively associated with suicidal ideation and entrapment. The association between homophobic violence and suicidal ideation was expected to be indirectly linked through entrapment. We explored whether various sources of social belongingness moderated the path between entrapment and suicidal ideation and whether those sources of social belongingness moderated the indirect effect of homophobic violence on suicidal ideation through entrapment. Results showed that homophobic violence and entrapment were positively associated with suicidal ideation and that family belongingness was negatively associated with suicidal ideation. Homophobic violence and suicidal ideation were not indirectly linked through entrapment. The interaction effect between entrapment and family belongingness was significant, suggesting that, on average, the effect of entrapment on suicidal ideation decreased when family belongingness was high. These results suggest that family belongingness may reduce the association between entrapment and suicidal ideation while adjusting for homophonic violence. Reducing entrapment and improving family belongingness may be useful targets for programs aimed at preventing suicidal ideation among sexual minority emerging adults

Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3.

Myeloproliferative neoplasms (MPN), which overproduce blood cells in the bone marrow, have recently been linked with a genetically determined decrease in expression of the MYB transcription factor. Here, we use a mouse MYB knockdown model with an MPN-like phenotype to show how lower levels of MYB lead to stem cell characteristics in myeloid progenitors. The altered progenitor properties feature elevated cytokine responsiveness, especially to IL-3, which results from increased receptor expression and increased MAPK activity leading to enhanced phosphorylation of a key regulator of protein synthesis, ribosomal protein S6. MYB acts on MAPK signaling by directly regulating transcription of the gene encoding the negative modulator SPRY2. This mechanistic insight points to pathways that might be targeted therapeutically in MPN.Leukemia accepted article preview online, 17 October 2016. doi:10.1038/leu.2016.289

Characterizing and modeling backscattering in silicon microring resonators

This paper was published in OPTICS EXPRESS and is made available as an electronic reprint with the permission of OSA. The paper can be found at the following URL on the OSA website: http://dx.doi.org/10.1364/OE.19.024980. Systematic or multiple reproduction or distribution to multiple locations via electronic or other means is prohibited and is subject to penalties under lawWe present an experimental technique to characterize back-scattering in silicon microring resonators, together with a simple analytical model that reproduces the experimental results. The model can extract all the key parameters of an add-drop-type resonator, which are the loss, both coupling coefficients and backscattering. We show that the backscattering effect strongly affects the resonance shape, and that consecutive resonances of the same ring can have very different backscattering parameters. © 2011 Optical Society of America.The authors acknowledge financial support from the Spanish Ministry of Science and Innovation through contract SINADEC (TEC2008-06333). Joaquin Matres is supported by the Formacion de Personal Investigador grant program of the Universidad Politecnica de Valencia.Ballesteros García, G.; Matres Abril, J.; Martí Sendra, J.; Oton Nieto, CJ. (2011). Characterizing and modeling backscattering in silicon microring resonators. Optics Express. 19(25):24980-24985. https://doi.org/10.1364/OE.19.024980S24980249851925De Vos, K., Bartolozzi, I., Schacht, E., Bienstman, P., & Baets, R. (2007). Silicon-on-Insulator microring resonator for sensitive and label-free biosensing. Optics Express, 15(12), 7610. doi:10.1364/oe.15.007610Almeida, V. R., Barrios, C. A., Panepucci, R. R., & Lipson, M. (2004). All-optical control of light on a silicon chip. Nature, 431(7012), 1081-1084. doi:10.1038/nature02921Dumon, P., Bogaerts, W., Wiaux, V., Wouters, J., Beckx, S., Van Campenhout, J., … Baets, R. (2004). Low-Loss SOI Photonic Wires and Ring Resonators Fabricated With Deep UV Lithography. IEEE Photonics Technology Letters, 16(5), 1328-1330. doi:10.1109/lpt.2004.826025Morichetti, F., Canciamilla, A., Martinelli, M., Samarelli, A., De La Rue, R. M., Sorel, M., & Melloni, A. (2010). Coherent backscattering in optical microring resonators. Applied Physics Letters, 96(8), 081112. doi:10.1063/1.3330894Little, B. E., Laine, J.-P., & Chu, S. T. (1997). Surface-roughness-induced contradirectional coupling in ring and disk resonators. Optics Letters, 22(1), 4. doi:10.1364/ol.22.000004Kippenberg, T. J., Spillane, S. M., & Vahala, K. J. (2002). Modal coupling in traveling-wave resonators. Optics Letters, 27(19), 1669. doi:10.1364/ol.27.001669Zhang, Z., Dainese, M., Wosinski, L., & Qiu, M. (2008). Resonance-splitting and enhanced notch depth in SOI ring resonators with mutual mode coupling. Optics Express, 16(7), 4621. doi:10.1364/oe.16.004621Morichetti, F., Canciamilla, A., Ferrari, C., Torregiani, M., Melloni, A., & Martinelli, M. (2010). Roughness Induced Backscattering in Optical Silicon Waveguides. Physical Review Letters, 104(3). doi:10.1103/physrevlett.104.033902Little, B. E., Chu, S. T., Haus, H. A., Foresi, J., & Laine, J.-P. (1997). Microring resonator channel dropping filters. Journal of Lightwave Technology, 15(6), 998-1005. doi:10.1109/50.588673Morichetti, F., Canciamilla, A., & Melloni, A. (2010). Statistics of backscattering in optical waveguides. Optics Letters, 35(11), 1777. doi:10.1364/ol.35.001777McKinnon, W. R., Xu, D. X., Storey, C., Post, E., Densmore, A., Delâge, A., … Janz, S. (2009). Extracting coupling and loss coefficients from a ring resonator. Optics Express, 17(21), 18971. doi:10.1364/oe.17.01897

A Reduced Order Approach for the Embedded Shifted Boundary FEM and a Heat Exchange System on Parametrized Geometries

A model order reduction technique is combined with an embedded boundary finite element method with a POD-Galerkin strategy. The proposed methodology is applied to parametrized heat transfer problems and we rely on a sufficiently refined shape-regular background mesh to account for parametrized geometries. In particular, the employed embedded boundary element method is the Shifted Boundary Method (SBM), recently proposed in Main and Scovazzi, J Comput Phys [17]. This approach is based on the idea of shifting the location of true boundary conditions to a surrogate boundary, with the goal of avoiding cut cells near the boundary of the computational domain. This combination of methodologies has multiple advantages. In the first place, since the Shifted Boundary Method always relies on the same background mesh, there is no need to update the discretized parametric domain. Secondly, we avoid the treatment of cut cell elements, which usually need particular attention. Thirdly, since the whole background mesh is considered in the reduced basis construction, the SBM allows for a smooth transition of the reduced modes across the immersed domain boundary. The performances of the method are verified in two dimensional heat transfer numerical examples