Superconducting Resonator-Rydberg Atom Hybrid in the Strong Coupling Regime

We propose a promising hybrid quantum system, where a highly-excited atom strongly interacts with a superconducting LC oscillator via the electric field of capacitor. An external electrostatic field is applied to tune the energy spectrum of atom. The atomic qubit is implemented by two eigenstates near an avoided-level crossing in the DC Stark map of Rydberg atom. Varying the electrostatic field brings the atomic-qubit transition on- or off-resonance to the microwave resonator, leading to a strong atom-resonator coupling with an extremely large cooperativity. Like the nonlinearity induced by Josephson junctions in superconducting circuits, the large atom-resonator interface disturbs the harmonic potential of resonator, resulting in an artificial two-level particle. Different universal two-qubit logic gates can also be performed on our hybrid system within the space where an atomic qubit couples to a single photon with an interaction strength much larger than any relaxation rates, opening the door to the cavity-mediated state transmission.Comment: 4 figure

Roadmap on quantum optical systems

This roadmap bundles fast developing topics in experimental optical quantum sciences, addressing current challenges as well as potential advances in future research. We have focused on three main areas: quantum assisted high precision measurements, quantum information/simulation, and quantum gases. Quantum assisted high precision measurements are discussed in the first three sections, which review optical clocks, atom interferometry, and optical magnetometry. These fields are already successfully utilized in various applied areas. We will discuss approaches to extend this impact even further. In the quantum information/simulation section, we start with the traditionally successful employed systems based on neutral atoms and ions. In addition the marvelous demonstrations of systems suitable for quantum information is not progressing, unsolved challenges remain and will be discussed. We will also review, as an alternative approach, the utilization of hybrid quantum systems based on superconducting quantum devices and ultracold atoms. Novel developments in atomtronics promise unique access in exploring solid-state systems with ultracold gases and are investigated in depth. The sections discussing the continuously fast- developing quantum gases include a review on dipolar heteronuclear diatomic gases, Rydberg gases, and ultracold plasma. Overall, we have accomplished a roadmap of selected areas undergoing rapid progress in quantum optics, highlighting current advances and future challenges. These exciting developments and vast advances will shape the field of quantum optics in the future

ICARUS-Q: A scalable RFSoC-based control system for superconducting quantum computers

We present a control and measurement setup for superconducting qubits based on Xilinx 16-channel radio frequency system on chip (RFSoC) device. The proposed setup consists of four parts: multiple RFSoC boards, a setup to synchronise every digital to analog converter (DAC), and analog to digital converter (ADC) channel across multiple boards, a low-noise direct current (DC) supply for tuning the qubit frequency and cloud access for remotely performing experiments. We also design the setup to be free of physical mixers. The RFSoC boards directly generate microwave pulses using sixteen DAC channels up to the third Nyquist zone which are directly sampled by its eight ADC channels between the fifth and the ninth zonesComment: Main text: 15 pages, 23 figures Appendix: 2 pages, 2 figure

Single-Cell Genetic Analysis Reveals Insights into Clonal Development of Prostate Cancers and Indicates Loss of PTEN as a Marker of Poor Prognosis

Gauging the risk of developing progressive disease is a major challenge in prostate cancer patient management. We used genetic markers to understand genomic alteration dynamics during disease progression. By using a novel, advanced, multicolor fluorescence in situ hybridization approach, we enumerated copy numbers of six genes previously identified by array comparative genomic hybridization to be involved in aggressive prostate cancer [TBL1XR1, CTTNBP2, MYC (alias c-myc), PTEN, MEN1, and PDGFB] in six nonrecurrent and seven recurrent radical prostatectomy cases. An ERG break-apart probe to detect TMPRSS2-ERG fusions was included. Subsequent hybridization of probe panels and cell relocation resulted in signal counts for all probes in each individual cell analyzed. Differences in the degree of chromosomal and genomic instability (ie, tumor heterogeneity) or the percentage of cells with TMPRSS2-ERG fusion between samples with or without progression were not observed. Tumors from patients that progressed had more chromosomal gains and losses, and showed a higher degree of selection for a predominant clonal pattern. PTEN loss was the most frequent aberration in progressers (57%), followed by TBL1XR1 gain (29%). MYC gain was observed in one progresser, which was the only lesion with an ERG gain, but no TMPRSS2-ERG fusion. According to our results, a probe set consisting of PTEN, MYC, and TBL1XR1 would detect progressers with 86% sensitivity and 100% specificity. This will be evaluated further in larger studies

Identifying differential predictors for treatment response to amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia: results of the COMBINE-study

Background Extensive research has been undertaken to predict treatment response (TR) to antipsychotics. Most studies address TR to antipsychotics in general and as monotherapy, however, it is unknown whether patients might respond favourably to a combination of antipsychotics. Aims This study aimed to identify differential predictors for TR to monotherapy with amisulpride or olanzapine compared to a combination of antipsychotics. Methods Post-hoc analysis was conducted of data collected from the COMBINE-study, a double-blind, randomized, controlled trial. Demographic and disease-related measures were gathered at baseline to predict TR after eight weeks defined by the Positive and Negative Syndrome Scale. Missing values were accounted for by a random replacement procedure. Attrition effects and multicollinearity were analysed and sets of logistic regression models were calculated for different treatment groups. Results Of the 321 randomized patients, 201 completed procedures until week eight and 197 were included in the analyses. For all treatment groups, early TR after two weeks and high subjective well-being under antipsychotics at baseline were robust predictors for TR. The propensity for early side effects also indicated a higher risk of later non-response. Specific parameter estimates were rather similar between treatment groups. Conclusion Early TR, drug-related subjective well-being, and early side effect propensity evolved as predictors for later TR whether to monotherapy or combination strategy. Accordingly, due to a lack of differential predictors, early and close monitoring of targeted and unwanted effects is indicated to guide respective treatment decisions

N-Acetylcysteine and a Specialized Preventive Intervention for Individuals at High Risk for Psychosis: A Randomized Double-Blind Multicenter Trial.

BACKGROUND AND HYPOTHESIS Clinical high risk for psychosis (CHR-P) offers a window of opportunity for early intervention and recent trials have shown promising results for the use of N-acetylcysteine (NAC) in schizophrenia. Moreover, integrated preventive psychological intervention (IPPI), applies social-cognitive remediation to aid in preventing the transition to the psychosis of CHR-P patients. STUDY DESIGN In this double-blind, randomized, controlled multicenter trial, a 2 × 2 factorial design was applied to investigate the effects of NAC compared to placebo (PLC) and IPPI compared to psychological stress management (PSM). The primary endpoint was the transition to psychosis or deterioration of CHR-P symptoms after 18 months. STUDY RESULTS While insufficient recruitment led to early trial termination, a total of 48 participants were included in the study. Patients receiving NAC showed numerically higher estimates of event-free survival probability (IPPI + NAC: 72.7 ± 13.4%, PSM + NAC: 72.7 ± 13.4%) as compared to patients receiving PLC (IPPI + PLC: 56.1 ± 15.3%, PSM + PLC: 39.0 ± 17.4%). However, a log-rank chi-square test in Kaplan-Meier analysis revealed no significant difference of survival probability for NAC vs control (point hazard ratio: 0.879, 95% CI 0.281-2.756) or IPPI vs control (point hazard ratio: 0.827, 95% CI 0.295-2.314). The number of adverse events (AE) did not differ significantly between the four groups. CONCLUSIONS The superiority of NAC or IPPI in preventing psychosis in patients with CHR-P compared to controls could not be statistically validated in this trial. However, results indicate a consistent pattern that warrants further testing of NAC as a promising and well-tolerated intervention for CHR patients in future trials with adequate statistical power

Culture-Independent Molecular Subtyping of Mycoplasma pneumoniae in Clinical Samples

A new molecular subtyping approach was developed which is based on the amplification and sequencing of a repetitive region of the P1 gene of Mycoplasma pneumoniae. It allows the differentiation of all known subtypes and variants of M. pneumoniae as well as the identification of new subtypes directly in clinical samples to characterize endemic and epidemic M. pneumoniae infections

Superconducting atom chips : towards quantum hybridization

Atomic-superconducting hybrid systems are of particular interest as they are combining the long coherence times of ultracold atoms and fast gate operation times of superconducting circuits. Here we discuss an experimental realization of an interface between cold Rydberg atoms and a transmon circuit embedded in a microwave cavity. We present numerical calculations showing a significant coupling of Rydberg atoms to a transmon. Here we place the atoms in the vicinity of the transmon shunting capacitor. Exciting them to the Rydberg states alters the dielectric constant of the medium inside the capacitor. This results in a dispersive shift of the transmon resonance frequency. Using the protocols developed in Ref. 1, 2 will allow the coherent transfer of quantum states between these two systems.NRF (Natl Research Foundation, S’pore)Published versio

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