Considerations regarding the Formulation of the Organisational Strategy through Simulation Techniques

The complexity, dimension and the scope of the economic problems specific to the correct development of organisational strategie require, on the one hand, the structuring and systematisation of their entire simulation activity in view of solving them. On the other hand, they require the adequacy of a relative independence resulted from the very nature of thinking, personality and professional education of those who wants to promote a certain type of organisational strategy. In other words, we can consider that the stages of creating a strategy simulation, although they are not compulsory, they cannot be entirely neglected, because there is minimum number of stages and sub-stages for which the optional character is not permitted. The entire decisional simulation cycle of a strategy obeys the three research levels: analysis, designing and management of the simulation activity.simulation; strategy; status of strategy; status of entropy; process.

Torre André et Jean-Eudes Beuret, Proximités territoriales, Economica, collection Anthropos, 2012, 105 p.

Dans leur introduction les auteurs annoncent d’emblée la couleur. L’approche des proximités doit permettre d’améliorer la compréhension des processus de gouvernance et de baliser des pistes d’action pour ceux qui pilotent les territoires. Pour y parvenir, les auteurs renversent la démarche utilisée jusqu’ici par l’école de la proximité. Les proximités sont habituellement prises comme des données préexistantes qui vont façonner les relations entre les acteurs des territoires. Ici, les proximit..

Introduction au dossier n°11 Catastrophes et Territoires

Les risques sont aujourd'hui omniprésents, à tel point que certains voient dans les mutations sociales et organisationnelles actuelles, l'émergence d'une société du risque, avatar, malheureux, d'une société industrielle ayant contribué certes à l'augmentation des richesses, mais au prix d'une absence de maîtrise technique, politique et scientifique des risques inhérents au progrès technique (Beck, 2001). Les sociétés dans leur globalité sont intéressées au premier chef par ces transformations..

Phenolic compounds, antioxidant and antibacterial activities of three Ericaceae from Algeria

International audienceHerbs of the Ericaceae family are commonly found in Algeria and used in traditional medicine as antiseptic, diuretic, astringent, depurative, and to treat scalds and wounds. The methanolic extracts of three species, Arbutus unedo L. (A. unedo, leaves), Erica arborea L. (E. arborea, flowered aerial parts), and Erica multiflora L. (E. multiflora, flowered aerial parts), were compared regarding their content in phenolic compounds, their antioxidant, and antibacterial activities. A. unedo harbors the highest content in total phenolics and flavonoids, followed by E. arboreaE. multiflora. The contents in total phenolics and flavonoids showed a correlation with the measured antioxidant (hydrogen-donating) activities; this was particularly the case for flavonoids content. The A. unedo extract showed antibacterial activity against all the tested strains (Staphylococcus aureus ATCC 6538, S. aureus C100459, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 9027); however, the E. arborea and E. multiflora extracts showed antibacterial activity only against Gram positive bacteria. Some polyphenols were identified in the three herbs by thin-layer chromatography and high-performance liquid chromatography coupled with diode array and mass spectrometry detection; from these, caffeic acid, p-coumaric acid, naringin, quercetin and kaempferol are reported for the first time in E. multiflora

Binary black holes in circular orbits. II. Numerical methods and first results

We present the first results from a new method for computing spacetimes representing corotating binary black holes in circular orbits. The method is based on the assumption of exact equilibrium. It uses the standard 3+1 decomposition of Einstein equations and conformal flatness approximation for the 3-metric. Contrary to previous numerical approaches to this problem, we do not solve only the constraint equations but rather a set of five equations for the lapse function, the conformal factor and the shift vector. The orbital velocity is unambiguously determined by imposing that, at infinity, the metric behaves like the Schwarzschild one, a requirement which is equivalent to the virial theorem. The numerical scheme has been implemented using multi-domain spectral methods and passed numerous tests. A sequence of corotating black holes of equal mass is calculated. Defining the sequence by requiring that the ADM mass decrease is equal to the angular momentum decrease multiplied by the orbital angular velocity, it is found that the area of the apparent horizons is constant along the sequence. We also find a turning point in the ADM mass and angular momentum curves, which may be interpreted as an innermost stable circular orbit (ISCO). The values of the global quantities at the ISCO, especially the orbital velocity, are in much better agreement with those from third post-Newtonian calculations than with those resulting from previous numerical approaches.Comment: 27 pages, 20 PostScript figures, improved presentation of the regularization procedure for the shift vector, new section devoted to the check of the momentum constraint, references added + minor corrections, accepted for publication in Phys. Rev.

Control of Gene Expression by the Retinoic Acid-Related Orphan Receptor Alpha in HepG2 Human Hepatoma Cells

Retinoic acid-related Orphan Receptor alpha (RORα; NR1F1) is a widely distributed nuclear receptor involved in several (patho)physiological functions including lipid metabolism, inflammation, angiogenesis, and circadian rhythm. To better understand the role of this nuclear receptor in liver, we aimed at displaying genes controlled by RORα in liver cells by generating HepG2 human hepatoma cells stably over-expressing RORα. Genes whose expression was altered in these cells versus control cells were displayed using micro-arrays followed by qRT-PCR analysis. Expression of these genes was also altered in cells in which RORα was transiently over-expressed after adenoviral infection. A number of the genes found were involved in known pathways controlled by RORα, for instance LPA, NR1D2 and ADIPOQ in lipid metabolism, ADIPOQ and PLG in inflammation, PLG in fibrinolysis and NR1D2 and NR1D1 in circadian rhythm. This study also revealed that genes such as G6PC, involved in glucose homeostasis, and AGRP, involved in the control of body weight, are also controlled by RORα. Lastly, SPARC, involved in cell growth and adhesion, and associated with liver carcinogenesis, was up-regulated by RORα. SPARC was found to be a new putative RORα target gene since it possesses, in its promoter, a functional RORE as evidenced by EMSAs and transfection experiments. Most of the other genes that we found regulated by RORα also contained putative ROREs in their regulatory regions. Chromatin immunoprecipitation (ChIP) confirmed that the ROREs present in the SPARC, PLG, G6PC, NR1D2 and AGRP genes were occupied by RORα in HepG2 cells. Therefore these genes must now be considered as direct RORα targets. Our results open new routes on the roles of RORα in glucose metabolism and carcinogenesis within cells of hepatic origin

La stratégie des universités publiques en matière de formation dans l'académie de Lille

Collection Éducation, formation et lien social.International audienc

Analyse des facteurs d'aléa de la violence dans les organisations du secteur sanitaire à partir de la pression temporelle

International audienceThis article suggests analyzing the possible factors of the risk of violence by supposing that the latter depends on the way the organizations of the sector propagates temporal pressure influenced by their environment. At first, we shall present the model of analysis of the temporal pressure of the environment before making a diagnosis on the risks in the organizations of the sector.Cet article se propose d’analyser les facteurs d’aléa du risque de violence en partant de l’hypothèse que celle-ci dépende de la façon dont les organisations du secteur propagent la pression temporelle exercée par leur environnement. Nous présenterons d’abord le modèle d’analyse de la pression temporelle de l’environnement avant d’effectuer un diagnostic sur les risques dans les organisations du secteur

La planification des proximités dans le domaine culturel. Le cas du Louvre-Lens

International audienceL’idée d’aménagement culturel fait son chemin dans de nombreux territoires qui utilisent la culture comme facteur de résilience. L’installation du Louvre à Lens constitue un bon exemple de cette politique. Cet article entend montrer comment on peut utiliser le concept de proximité pour mieux comprendre comment cela pourrait se passer. Cela passe d’abord par la présentation des conditions épistémologiques d’utilisation du concept puis par une réorientation de la démarche d’évaluation mise en place au sein de la plate-forme d’intelligence collective Euralens

Habiter un monde plus humain. L'éthique d'un contrat géographique fondé sur le vivable

International audienc