11 research outputs found
Extremely large magnetoresistance in topologically trivial semimetal -WP
Extremely large magnetoresistance (XMR) was recently discovered in many
non-magnetic materials, while its underlying mechanism remains poorly
understood due to the complex electronic structure of these materials. Here, we
report an investigation of the -phase WP, a topologically trivial
semimetal with monoclinic crystal structure (C2/m), which contrasts to the
recently discovered robust type-II Weyl semimetal phase in -WP. We
found that -WP exhibits almost all the characteristics of XMR
materials: the near-quadratic field dependence of MR, a field-induced up-turn
in resistivity following by a plateau at low temperature, which can be
understood by the compensation effect, and high mobility of carriers confirmed
by our Hall effect measurements. It was also found that the normalized MRs
under different magnetic fields has the same temperature dependence in
-WP, the Kohler scaling law can describe the MR data in a wide
temperature range, and there is no obvious change in the anisotropic parameter
value with temperature. The resistance polar diagram has a peanut
shape when field is rotated in plane, which can be understood by
the anisotropy of Fermi surface. These results indicate that both
field-induced-gap and temperature-induced Lifshitz transition are not the
origin of up-turn in resistivity in the -WP semimetal. Our findings
establish -WP as a new reference material for exploring the XMR
phenomena.Comment: 18 pages, 12 figure
From American Westward Movement to Chinese Western Development------ General analysis of relationships between institutions and Economic development as well as the enlightenment for China
Ripples into waves: trade networks, economic activity, and asset prices
We exploit information in sovereign CDS spreads and the international trade network to provide causal evidence of the propagation of global economic shocks. We show that trade links are an important source of shock transmission using the natural experiments of the Japanese tsunami and the COVID-19 lockdown in China. We then confirm more general and gradual information flows along the trade network by showing extensive country-level credit/equity cross-sectional return predictability. News about country fundamentals flows primarily from importers to exporters, depends on both direct and indirect links in the trade network, and is magnified by the exporting country's financial vulnerability
Epidermal Growth Factor Receptor-Targeted Neoantigen Peptide Vaccination for the Treatment of Non-Small Cell Lung Cancer and Glioblastoma
The epidermal growth factor receptor (EGFR) plays crucial roles in several important biological functions such as embryogenesis, epithelial tissue development, and cellular regeneration. However, in multiple solid tumor types overexpression and/or activating mutations of the EGFR gene frequently occur, thus hijacking the EGFR signaling pathway to promote tumorigenesis. Non-small cell lung cancer (NSCLC) tumors in particular often contain prevalent and shared EGFR mutations that provide an ideal source for public neoantigens (NeoAg). Studies in both humans and animal models have confirmed the immunogenicity of some of these NeoAg peptides, suggesting that they may constitute viable targets for cancer immunotherapies. Peptide vaccines targeting mutated EGFR have been tested in multiple clinical trials, demonstrating an excellent safety profile and encouraging clinical efficacy. For example, the CDX-110 (rindopepimut) NeoAg peptide vaccine derived from the EGFRvIII deletion mutant in combination with temozolomide and radiotherapy has shown efficacy in treating EGFRvIII-harboring glioblastoma multiforme (GBM) patients undergone surgery in multiple Phase I and II clinical trials. Furthermore, pilot clinical trials that have administered personalized NeoAg peptides for treating advanced-stage NSCLC patients have shown this approach to be a feasible and safe method to increase antitumor immune responses. Amongst the vaccine peptides administered, EGFR mutation-targeting NeoAgs induced the strongest T cell-mediated immune responses in patients and were also associated with objective clinical responses, implying a promising future for NeoAg peptide vaccines for treating NSCLC patients with selected EGFR mutations. The efficacy of NeoAg-targeting peptide vaccines may be further improved by combining with other modalities such as tyrosine kinase or immune checkpoint inhibitor (ICI) therapy, which are currently being tested in animal models and clinical trials. Herein, we review the most current basic and clinical research progress on EGFR-targeted peptide vaccination for the treatment of NSCLC and other solid tumor types
Linear and quadratic magnetoresistance in the semimetal SiP2
Multiple mechanisms for extremely large magnetoresistance (XMR) found in many
topologically nontrivial/trivial semimetals have been theoretically proposed,
but experimentally it is unclear which mechanism is responsible in a particular
sample. In this article, by the combination of band structure calculations,
numerical simulations of magnetoresistance (MR), Hall resistivity and de
Haas-van Alphen (dHvA) oscillation measurements, we studied the MR anisotropy
of SiP which is verified to be a topologically trivial, incomplete
compensation semimetal. It was found that as magnetic field, , is applied
along the axis, the MR exhibits an unsaturated nearly linear
dependence, which was argued to arise from incomplete carriers compensation.
For the [101] orientation, an unsaturated nearly quadratic
dependence of MR up to 5.88 10 (at 1.8 K, 31.2 T) and
field-induced up-turn behavior in resistivity were observed, which was
suggested due to the existence of hole open orbits extending along the
direction. Good agreement of the experimental results with the simulations
based on the calculated Fermi surface (FS) indicates that the topology of FS
plays an important role in its MR.Comment: 9 pages, 8 figure