458 research outputs found
Gender, Oration, and Variable Affrication in Ende
This paper explores sociophonetic variation in Ende, a Pahoturi River (Papuan) language spoken by the Ende tän, and adds to a growing body of variationist work taking place in southern New Guinea. We examine variable affrication of Ende retroflex obstruents through conducting an auditory analysis of spontaneous speech produced by 16 speakers of Ende, and we consider what linguistic and social factors are linked with this variation. Specifically, we highlight the locally relevant social factor of participation in community oration, a prestigious practice in Ende society. The research thus provides a much-needed contrast and comparison with dominant sociolinguistic theories. The results provide evidence that retroflex obstruents in Ende are more likely to be realized as stops when produced by those who perform orations. Among the orators, the frequency of stop realizations is linked with age and gender, such that older, women orators produce more stops. In contrast, no age- or gender-based differences are observed among the non-orators. We argue that women orators are using the stop variant to assert symbolic power in a community where oration is one of the few avenues of power available to women
The Seedskadee Project: Remote Sensing in Non-Site Archeology
The project area includes some 185,000 acres of land along the banks of the Green River below the Fontenelle Dam in southwestern Wyoming. The Statement of Work calls for 1) a Class I Cultural Resources Survey and Remote Sensing Survey to assess the general nature of the resources, 2) the preparation of a predictive study design based on available information, and 3) a ground truth survey on a small sample of the project area. This proposal discusses the methods that the Branch of Remote Sensing of the Division of Cultural Research of the Southwest Cultural Resources Center of the National Park Service proposes to follow to comply with the requirements into three separate types. The Branch will conduct two out-of-house subcontracts and several in-house studies
Predictors of undergoing multivisceral resection, margin status and survival in Dutch patients with locally advanced colorectal cancer
Background: The aim of this nationwide observational study was to evaluate factors associated with multivisceral resection (MVR), margin status and overall survival in locally advanced colorectal cancer (CRC). Material and methods: Patients with (y)pT4, cM0 CRC between 2006 and 2017 were selected from the Netherlands Cancer Registry. Cox-proportional hazards modelling was used for survival analysis, stratified for T4a and T4b. Annual hospital volume cut-off was 75 for colon and 40 for rectal resections. Results: A total of 11.930 patients were included and 2410 patients (20.2%) underwent MVR. Factors associated with MVR for colon and rectal cancer besides cT4 category were more recent diagnosis (OR 3.61, CI 95% 3.06–4.25 (colon) and OR 2.72, CI 95% 1.82–4.08 (rectum)) and high hospital volume (OR 1.20, CI 95% 1.05–1.38 (colon) and OR 2.17, CI 95% 1.55–3.04 (rectum)). Patients ≥70 year were less likely to undergo MVR for colon cancer (OR 0.80, 95% CI 0.70–0.90). Risk factors for incomplete resection were cT4 (OR 3.08, CI 95% 2.35–4.04 (colon) and OR 1.82, CI 95% 1.13–2.94 (rectum)) and poor/undifferentiated tumors (OR 1.41, CI 95% 1.14–1.72 (colon) and OR 1.69, CI 95% 1.05–2.74 (rectum)). More recent diagnosis was independently associated with less incomplete resections in colon cancer (OR 0.58, CI 95% 0.40–0.76). Independent predictors of survival were age, resection margin, nodal status and adjuvant chemotherapy, but not MVR. Conclusion: Treatment of locally advanced CRC with MVR at population level was influenced by year of diagnosis and hospital volume. Margin status in colon cancer improved substantially over time.</p
Predictors of undergoing multivisceral resection, margin status and survival in Dutch patients with locally advanced colorectal cancer
Background: The aim of this nationwide observational study was to evaluate factors associated with multivisceral resection (MVR), margin status and overall survival in locally advanced colorectal cancer (CRC). Material and methods: Patients with (y)pT4, cM0 CRC between 2006 and 2017 were selected from the Netherlands Cancer Registry. Cox-proportional hazards modelling was used for survival analysis, stratified for T4a and T4b. Annual hospital volume cut-off was 75 for colon and 40 for rectal resections. Results: A total of 11.930 patients were included and 2410 patients (20.2%) underwent MVR. Factors associated with MVR for colon and rectal cancer besides cT4 category were more recent diagnosis (OR 3.61, CI 95% 3.06–4.25 (colon) and OR 2.72, CI 95% 1.82–4.08 (rectum)) and high hospital volume (OR 1.20, CI 95% 1.05–1.38 (colon) and OR 2.17, CI 95% 1.55–3.04 (rectum)). Patients ≥70 year were less likely to undergo MVR for colon cancer (OR 0.80, 95% CI 0.70–0.90). Risk factors for incomplete resection were cT4 (OR 3.08, CI 95% 2.35–4.04 (colon) and OR 1.82, CI 95% 1.13–2.94 (rectum)) and poor/undifferentiated tumors (OR 1.41, CI 95% 1.14–1.72 (colon) and OR 1.69, CI 95% 1.05–2.74 (rectum)). More recent diagnosis was independently associated with less incomplete resections in colon cancer (OR 0.58, CI 95% 0.40–0.76). Independent predictors of survival were age, resection margin, nodal status and adjuvant chemotherapy, but not MVR. Conclusion: Treatment of locally advanced CRC with MVR at population level was influenced by year of diagnosis and hospital volume. Margin status in colon cancer improved substantially over time.</p
Instanton approach to the Langevin motion of a particle in a random potential
We develop an instanton approach to the non-equilibrium dynamics in
one-dimensional random environments. The long time behavior is controlled by
rare fluctuations of the disorder potential and, accordingly, by the tail of
the distribution function for the time a particle needs to propagate along the
system (the delay time). The proposed method allows us to find the tail of the
delay time distribution function and delay time moments, providing thus an
exact description of the long-time dynamics. We analyze arbitrary environments
covering different types of glassy dynamics: dynamics in a short-range random
field, creep, and Sinai's motion.Comment: 4 pages, 1 figur
Critical analysis of autoregressive and fast Fourier transform markers of cardiovascular variability in rats and humans
The autonomic nervous system plays an important role in physiological and pathological conditions, and has been extensively evaluated by parametric and non-parametric spectral analysis. To compare the results obtained with fast Fourier transform (FFT) and the autoregressive (AR) method, we performed a comprehensive comparative study using data from humans and rats during pharmacological blockade (in rats), a postural test (in humans), and in the hypertensive state (in both humans and rats). Although postural hypotension in humans induced an increase in normalized low-frequency (LFnu) of systolic blood pressure, the increase in the ratio was detected only by AR. In rats, AR and FFT analysis did not agree for LFnu and high frequency (HFnu) under basal conditions and after vagal blockade. The increase in the LF/HF ratio of the pulse interval, induced by methylatropine, was detected only by FFT. In hypertensive patients, changes in LF and HF for systolic blood pressure were observed only by AR; FFT was able to detect the reduction in both blood pressure variance and total power. In hypertensive rats, AR presented different values of variance and total power for systolic blood pressure. Moreover, AR and FFT presented discordant results for LF, LFnu, HF, LF/HF ratio, and total power for pulse interval. We provide evidence for disagreement in 23% of the indices of blood pressure and heart rate variability in humans and 67% discordance in rats when these variables are evaluated by AR and FFT under physiological and pathological conditions. The overall disagreement between AR and FFT in this study was 43%.FINEPFAPESPZerbini Foundatio
SBML2LaTEX: Conversion of SBML files into human-readable reports
Summary: The XML-based Systems Biology Markup Language (SBML) has emerged as a standard for storage, communication and interchange of models in systems biology. As a machine-readable format XML is difficult for humans to read and understand. Many tools are available that visualize the reaction pathways stored in SBML files, but many components, e.g. unit declarations, complex kinetic equations or links to MIRIAM resources, are often not made visible in these diagrams. For a broader understanding of the models, support in scientific writing and error detection, a human-readable report of the complete model is needed. We present SBML2LaTEX, a Java-based stand-alone program to fill this gap. A convenient web service allows users to directly convert SBML to various formats, including DVI, LaTEX and PDF, and provides many settings for customization
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Modeling the scaling properties of human mobility
While the fat tailed jump size and the waiting time distributions
characterizing individual human trajectories strongly suggest the relevance of
the continuous time random walk (CTRW) models of human mobility, no one
seriously believes that human traces are truly random. Given the importance of
human mobility, from epidemic modeling to traffic prediction and urban
planning, we need quantitative models that can account for the statistical
characteristics of individual human trajectories. Here we use empirical data on
human mobility, captured by mobile phone traces, to show that the predictions
of the CTRW models are in systematic conflict with the empirical results. We
introduce two principles that govern human trajectories, allowing us to build a
statistically self-consistent microscopic model for individual human mobility.
The model not only accounts for the empirically observed scaling laws but also
allows us to analytically predict most of the pertinent scaling exponents
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