1 research outputs found
The DielsâAlder Approach towards Cannabinoid Derivatives and Formal Synthesis of Tetrahydrocannabinol (THC)
Abstract Based on the DielsâAlder reaction of vinylchromenes with electronâpoor dienophiles, we developed a strategy for the synthesis of tetrahydrocannabinol derivatives. Substituted vinyl chromenes could be converted with several dienophiles to successfully isolate several complex molecules. These molecules already contain the cannabinoidâlike base structure and further processing of one such derivative led to a precursor of Î9âtetrahydrocannabinol. The most challenging step towards this precursor was an epoxidation step that was ultimately achieved via dimethyl dioxirane