Ayurvedic understanding of Central Pontine Myelinolysis - A Case Report

A 56 year old male patient was admitted to S.D.M Ayurveda Hospital, Hassan, Karnataka with the confirmed diagnosis of Central Pontine Myelinolysis (CPM) on 11/12/17. The chief complaints were weakness of both hands and legs, stiffness in both hands and legs, pain in both shoulder joints, slurred speech, difficulty in walking with gait changes. H/O chronic alcoholism. MRI brain showed pontine and basal ganglia diffusion restriction - Acute Pontine Myelinolysis. The serum electrolyte showed serum sodium level as 128 mmol/litre. This disease can be understood as Samana Avruta Vyana in hyponatremic encephalopathy stage and the stage of myelinolysis can be understood as Sarvanga Vata with Kapha Avruta Udana and Vyana. After clinical evaluation, Avarana Chikitsa was started followed by Kevala Vatika Chikitsa and significant improvement was seen. Significant result was observed in subjective and objective parameters after the treatment. The patient was discharged with oral medications for 1 month

Boon of Acharya Vagbhata - The Vata Pentad

Vata is one among the Tridoshas that contributes to 80 types of Nanatmaja Vikaras. It can also leads to the manifestation of other disorders where Vata plays the role of an Anubandha Dosha. To understand the Avasthavishesha of any Vyadhi, the contribution of each Doshas should be separately identified. This is possible by knowing the Dosha Vruddhi Kshaya Lakshanas. The first step in the Chikitsa is Nidana Parivarjana. Because the Rogautpatti starts with Nidana Sevana. For this, detailed knowledge about the Prakopa Nidanas are essential. Among the Brihattrayees, Ashtanga Hrudaya of Vagbhataacharya stands unique in explaining the Vishesha Prakopa Nidanas of Panchavata in 19th chapter of Nidanasthana, Vatashonita Nidana. The knowledge about the Vishesha Prakopa Nidana of each Vata throws a clarity about the etiology and pathogenesis of all diseases, especially Vata Vyadhis. This article aims at exploring and analyzing the Vishesha Prakopa Nidanas said by Acharya Vagbhata in Ashtanga Hrudaya

An Ayurvedic approach towards Koshta Shakhashrita Kamala w.s.r. to Alcoholic Hepatitis - A Case Report

Alcohol consumption has been contributing 47% mortality all around the globe, and the liver disease rates are steadily increasing over the years. Along with alcoholic consumption, modern day life style and food habits contribute to the etiology of Alcoholic hepatitis. The symptomatology include nausea, loss of appetite, fatigue, jaundice, abdominal pain, yellowish discolouration of urine and sclera etc. It has been a challenge to treat the condition because both management of symptoms and withdrawal from the alcohol intake should go hand in hand. In Ayurveda this condition can be considered under Koshta Shakhashrita Kamala where the symptoms are analogous to alcoholic hepatitis. In this case, the subject presented with complaints of yellowish discolouration of sclera and urine, abdominal pain, nausea and general weakness since 15 days and was having h/o alcoholic consumption since 18 years. Elevated levels of serum bilirubin, SGOT, SGPT, ESR and prothrombin time and reduced level of WBC count and platelets were observed in laboratory investigation. Ayurvedic classical method of treatment was given to the subject and analysis of subjective and objective parameters were done before and after treatment

Eczema : Management through Ayurveda - A Case Report

Introduction: Eczema, Greek for ‘boil out’[1] is a pruritic disease associated with IgE sensitization. Usually occurring in childhood[2] with a recognised adult onset variation. The frequency of Eczema is as high as 20% in childhood and 0.9% in adults. 1/3rd of the affected individuals develop allergic rhinitis and 1/3rd develop asthma as a complication,[3] making early intervention essential. Vicharchika clinically correlates to Eczema. Management principle is primarily based on Shodhana and Raktaprasadana. Methods: The current report is based on a case of Eczema that presented as scaly skin lesions, intense itching, purulent discharge associated with tenderness and burning sensation. It was diagnosed as Vicharchika with Pittanubandha. Treatment included Raktamokshana, DeepanaPachana, Snehapana, Abhyanga and Virechana. Assessment was done based on subjective and objective parameters. Result: Reduction in pruritus, burning sensation and discharge was noted. Discussion: Ayurveda management with Kushta Chikitsa provided accelerated results in this case

Cardio-metabolic risk factors and prehypertension in persons without diabetes, hypertension, and cardiovascular disease

10.1186/1471-2458-13-730BMC Public Health131

Younger age of escalation of cardiovascular risk factors in Asian Indian subjects

<p>Abstract</p> <p>Background</p> <p>Cardiovascular risk factors start early, track through the young age and manifest in middle age in most societies. We conducted epidemiological studies to determine prevalence and age-specific trends in cardiovascular risk factors among adolescent and young urban Asian Indians.</p> <p>Methods</p> <p>Population based epidemiological studies to identify cardiovascular risk factors were performed in North India in 1999–2002. We evaluated major risk factors-smoking or tobacco use, obesity, truncal obesity, hypertension, dysglycemia and dyslipidemia using pre-specified definitions in 2051 subjects (male 1009, female 1042) aged 15–39 years of age. Age-stratified analyses were performed and significance of trends determined using regression analyses for numerical variables and Χ²test for trend for categorical variables. Logistic regression was used to identify univariate and multivariate odds ratios (OR) for correlation of age and risk factors.</p> <p>Results</p> <p>In males and females respectively, smoking or tobacco use was observed in 200 (11.8%) and 18 (1.4%), overweight or obesity (body mass index, BMI ≥ 25 kg/m²) in 12.4% and 14.3%, high waist-hip ratio, WHR (males > 0.9, females > 0.8) in 15% and 32.3%, hypertension in 5.6% and 3.1%, high LDL cholesterol (≥ 130 mg/dl) in 9.4% and 8.9%, low HDL cholesterol (<40 mg/dl males, <50 mg/dl females) in 16.2% and 49.7%, hypertriglyceridemia (≥ 150 mg/dl) in 9.7% and 6%, diabetes in 1.0% and 0.4% and the metabolic syndrome in 3.4% and 3.6%. Significantly increasing trends with age for indices of obesity (BMI, waist, WHR), glycemia (fasting glucose, metabolic syndrome) and lipids (cholesterol, LDL cholesterol, HDL cholesterol) were observed (p for trend < 0.01). At age 15–19 years the prevalence (%) of risk factors in males and females, respectively, was overweight/obesity in 7.6, 8.8; high WHR 4.9, 14.4; hypertension 2.3, 0.3; high LDL cholesterol 2.4, 3.2; high triglycerides 3.0, 3.2; low HDL cholesterol 8.0, 45.3; high total:HDL ratio 3.7, 4.7, diabetes 0.0 and metabolic syndrome in 0.0, 0.2 percent. At age groups 20–29 years in males and females, ORs were, for smoking 5.3, 1.0; obesity 1.6, 0.8; truncal obesity 4.5, 3.1; hypertension 2.6, 4.8; high LDL cholesterol 6.4, 1.8; high triglycerides 3.7, 0.9; low HDL cholesterol 2.4, 0.8; high total:HDL cholesterol 1.6, 1.0; diabetes 4.0, 1.0; and metabolic syndrome 37.7, 5.7 (p < 0.05 for some). At age 30–39, ORs were- smoking 16.0, 6.3; overweight 7.1, 11.3; truncal obesity 21.1, 17.2; hypertension 13.0, 64.0; high LDL cholesterol 27.4, 19.5; high triglycerides 24.2, 10.0; low HDL cholesterol 15.8, 14.1; high total:HDL cholesterol 37.9, 6.10; diabetes 50.7, 17.4; and metabolic syndrome 168.5, 146.2 (p < 0.01 for all parameters). Multivariate adjustment for BMI, waist size and WHR in men and women aged 30–39 years resulted in attenuation of ORs for hypertension and dyslipidemias.</p> <p>Conclusion</p> <p>Low prevalence of multiple cardiovascular risk factors (smoking, hypertension, dyslipidemias, diabetes and metabolic syndrome) in adolescents and rapid escalation of these risk factors by age of 30–39 years is noted in urban Asian Indians. Interventions should focus on these individuals.</p

IZ KAJKAVSKE MORFOLOGIJE (o DL sg. im. ž. roda)

U radu se nastoji dati odgovor na pitanje: da li je u svim govorima kajkavskoga narječja u kojima je u DL sg. imenica ženskoga roda morfem –i riječ o generalizaciji toga morfema iz nekadašnjih ja-osnova ili se u govorima s ograničenom distribucijom kontinuante jata i šva (u dijelu govora samo jata) i njegovom zamjenom vokalom i, ili vokalom i-tipa, u nenaglašenim slogovima, može govoriti o morfemu –i < -ẹ < ě

Effect of wood smoke exposure on vascular function and thrombus formation in healthy fire fighters

Background: Myocardial infarction is the leading cause of death in fire fighters and has been linked with exposure to air pollution and fire suppression duties. We therefore investigated the effects of wood smoke exposure on vascular vasomotor and fibrinolytic function, and thrombus formation in healthy fire fighters. Methods: In a double-blind randomized cross-over study, 16 healthy male fire fighters were exposed to wood smoke (~1 mg/m3 particulate matter concentration) or filtered air for one hour during intermittent exercise. Arterial pressure and stiffness were measured before and immediately after exposure, and forearm blood flow was measured during intra-brachial infusion of endothelium-dependent and -independent vasodilators 4–6 hours after exposure. Thrombus formation was assessed using the ex vivo Badimon chamber at 2 hours, and platelet activation was measured using flow cytometry for up to 24 hours after the exposure. Results: Compared to filtered air, exposure to wood smoke increased blood carboxyhaemoglobin concentrations (1.3% versus 0.8%; P &lt; 0.001), but had no effect on arterial pressure, augmentation index or pulse wave velocity (P &gt; 0.05 for all). Whilst there was a dose-dependent increase in forearm blood flow with each vasodilator (P &lt; 0.01 for all), there were no differences in blood flow responses to acetylcholine, sodium nitroprusside or verapamil between exposures (P &gt; 0.05 for all). Following exposure to wood smoke, vasodilatation to bradykinin increased (P = 0.003), but there was no effect on bradykinin-induced tissue-plasminogen activator release, thrombus area or markers of platelet activation (P &gt; 0.05 for all). Conclusions: Wood smoke exposure does not impair vascular vasomotor or fibrinolytic function, or increase thrombus formation in fire fighters. Acute cardiovascular events following fire suppression may be precipitated by exposure to other air pollutants or through other mechanisms, such as strenuous physical exertion and dehydration.Originally included in thesis in manuscript form.</p