The scientific evaluation of Rasnadashamula Kwatha in the management of Amavata w.s.r. to Rheumatoid arthritis: A Review Article

Background: Rheumatoid arthritis (RA) is the most common inflammatory arthritis in women and hence an important cause of potentially preventable disability. Many of the clinical features and management strategies in RA are relevant across the spectrum of inflammatory joint disease. The typical clinical phenotype of RA is a Symmetrical, deforming, small and large joint polyarthritis, often associated with systemic disturbance and extraarticular disease. The clinical course is usually life-long, with intermittent exacerbations and remissions and highly variable severity. In Ayurveda, ‘Amavata’ was mentioned for the first time by Acharya Madhavakara has a special disease entity in which both ‘Ama’ as well as ‘Vata’ play a predominant role in the pathogenesis of this disease. Aim: The Article is written with the aim to analyze the of mode of action of the ingredients of Rasnadashamula Kwatha and explore its importance in relieving the symptoms of Amavata w.s.r. to Rheumatoid arthritis. Methodology: Rasnadashamula Kwatha is described in Amavata Rogadhikara in Chakradatta . Various peer reviewed articles, Ayurvedic classical textbooks, Modern Rheumatological textbooks as well as the online databases were analyzed under the relevant key words in understanding the importance of the above-mentioned formulation in treating the symptoms of Amavata w.s.r. to Rheumatoid arthritis. Conclusion: It can be concluded through literary review that Rasnadashamula Kwatha is efficient in relieving the symptoms of Amavata but to establish the final conclusion clinical trial of this drug should be conducted so that this drug can be used for therapeutic purposes in general patients of Amavata

Global polarization of Λ and Λ hyperons in Pb-Pb collisions at √ s N N = 2.76 and 5.02 TeV

The global polarization of Λ and Λ hyperons is measured for Pb-Pb collisions at √sNN = 2.76 and 5.02 TeV recorded with the ALICE at the Large Hadron Collider (LHC). The results are reported differentially as a function of collision centrality and hyperon’s transverse momentum (pT ) for the range of centrality 5–50%, 0.5 < pT < 5 GeV/c, and rapidity |y| < 0.5. The hyperon global polarization averaged for Pb-Pb collisions at √sNN = 2.76 and 5.02 TeV is found to be consistent with zero, ⟨PH⟩(%)≈0.01±0.06(stat.)±0.03(syst.) in the collision centrality range 15–50%, where the largest signal is expected. The results are compatible with expectations based on an extrapolation from measurements at lower collision energies at the Relativistic Heavy Ion Collider, hydrodynamical model calculations, and empirical estimates based on collision energy dependence of directed flow, all of which predict the global polarization values at LHC energies of the order of 0.01%