1,651 research outputs found

    Optimizing Regional Therapy for Melanoma

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    A review of the community flood risk management literature in the USA: lessons for improving community resilience to floods

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    This study systematically reviews the diverse body of research on community flood risk management in the USA to identify knowledge gaps and develop innovative and practical lessons to aid flood management decision-makers in their efforts to reduce flood losses. The authors discovered and reviewed 60 studies that met the selection criteria (e.g., study is written in English, is empirical, focuses on flood risk management at the community level in the USA, etc.). Upon reviewing the major findings from each study, the authors identified seven practical lessons that, if implemented, could not only help flood management decision-makers better understand communities’ flood risks, but could also reduce the impacts of flood disasters and improve communities’ resilience to future flood disasters. These seven lessons include: (1) recognizing that acquiring open space and conserving wetlands are some of the most effective approaches to reducing flood losses; (2) recognizing that, depending on a community’s flood risks, different development patterns are more effective at reducing flood losses; (3) considering the costs and benefits of participating in FEMA’s Community Rating System program; (4) engaging community members in the flood planning and recovery processes; (5) considering socially vulnerable populations in flood risk management programs; (6) relying on a variety of floodplain management tools to delineate flood risk; and (7) ensuring that flood mitigation plans are fully implemented and continually revised

    A review of community flood risk management studies in the United States

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    Given the substantial and diverse body of research on community flood risk management in the United States, there is a need to establish the current state of knowledge, synthesize the methodological dimensions of community flood risk management studies, and identify directions for future research on community flood risk management. The present study addresses these needs by conducting a comprehensive and systematic review of community flood risk management empirical studies in the United States. We searched three academic databases and identified 60 studies that met our selection criteria (e.g., study must be focused on flood risk management at the community level and conducted in the United States). Findings indicate that the number of studies on community flood risk management is increasing, most studies employ flood mitigation and flood impact as their dependent variables, the preferred analytical method is regression, and this literature is dominated by social scientists, among other findings. We discuss six themes that emerge, present four recommendations based on the gaps identified, and outline a robust research agenda for enhancing communities' resilience to future flood disasters

    Management of In-Transit Malignant Melanoma

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    Clinical Outcomes After Four-Level Anterior Cervical Discectomy and Fusion.

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    Study Design: Retrospective cohort study. Objectives: Anterior cervical discectomy and fusion (ACDF) demonstrates reliable improvement in neurologic symptoms associated with anterior compression of the cervical spine. There is a paucity of data on outcomes following 4-level ACDFs. The purpose of this study was to evaluate clinical outcomes for patients undergoing 4-level ACDF. Methods: All 4-level ACDFs with at least 1-year clinical follow-up were identified. Clinical outcomes, including fusion rates, neurologic outcomes, and reoperation rates were determined. Results: Retrospective review of our institutional database revealed 25 patients who underwent 4-level ACDF with at least 1-year clinical follow-up. Average age was 57.5 years (range 38.2-75.0 years); 14 (56%) were male, and average body mass index was 30.2 kg/m Conclusions: Review of our institution\u27s experience demonstrated a low rate of revision cervical surgery for any reason of 8% at mean 19 months follow-up, and neurological examinations consistently improved, despite a high rate of radiographic nonunion (31%)

    Timing and location of reproduction in African waterfowl: an overview of >100 years of nest records

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    The timing and location of reproduction are fundamental elements of reproductive success for all organisms. Understanding why animals choose to reproduce at particular times and in particular places is also important for our understanding of other aspects of organismal ecology, such as their habitat requirements, movement strategies, and biogeography. Although breeding patterns in waterfowl are relatively well documented, most studies are from northern temperate regions and the influences of location and time of year on breeding in Afrotropical ducks (Anatidae) are poorly understood. We outline six alternative (but not mutually exclusive) hypotheses that might explain where and when Afrotropical ducks choose to breed. To explore these hypotheses, we assembled and analyzed a new database of c.22,000 breeding records for 16 Afrotropical ducks and one introduced Palearctic species (the Mallard Anas platyrhynchos). The full database is available on line as an appendix to this article. We identified five distinct breeding strategies as well as two outliers. Peak breeding for 9 of 16 indigenous duck species occurs during the dry season. We found no evidence for spatial synchrony or spatial autocorrelation in breeding, suggesting a high level of flexibility in waterfowl responses to prevailing conditions in any given year. More intensive analyses of alternative hypotheses are needed, but our initial analysis suggests that the timing of breeding for the majority of Afrotropical ducks is driven by a combination of resource availability and predation risk

    Preliminary evidence of increased striatal dopamine in a nonhuman primate model of maternal immune activation.

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    Women exposed to a variety of viral and bacterial infections during pregnancy have an increased risk of giving birth to a child with autism, schizophrenia or other neurodevelopmental disorders. Preclinical maternal immune activation (MIA) models are powerful translational tools to investigate mechanisms underlying epidemiological links between infection during pregnancy and offspring neurodevelopmental disorders. Our previous studies documenting the emergence of aberrant behavior in rhesus monkey offspring born to MIA-treated dams extends the rodent MIA model into a species more closely related to humans. Here we present novel neuroimaging data from these animals to further explore the translational potential of the nonhuman primate MIA model. Nine male MIA-treated offspring and 4 controls from our original cohort underwent in vivo positron emission tomography (PET) scanning at approximately 3.5-years of age using [18F] fluoro-l-m-tyrosine (FMT) to measure presynaptic dopamine levels in the striatum, which are consistently elevated in individuals with schizophrenia. Analysis of [18F]FMT signal in the striatum of these nonhuman primates showed that MIA animals had significantly higher [18F]FMT index of influx compared to control animals. In spite of the modest sample size, this group difference reflects a large effect size (Cohen's d = 0.998). Nonhuman primates born to MIA-treated dams exhibited increased striatal dopamine in late adolescence-a hallmark molecular biomarker of schizophrenia. These results validate the MIA model in a species more closely related to humans and open up new avenues for understanding the neurodevelopmental biology of schizophrenia and other neurodevelopmental disorders associated with prenatal immune challenge

    Neutrino-Induced Giant Air Showers in Large Extra Dimension Models

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    In models based on large extra dimensions where massive spin 2 exchange can dominate at high energies, the neutrino-proton cross section can rise to typical hadronic values at energies above 10^20 eV. The neutrino then becomes a candidate for the primary that initiates the highest energy cosmic ray showers. We investigate characteristics of neutrino-induced showers compared to proton-induced showers. The comparison includes study of starting depth, profile with depth, lateral particle distribution at ground and muon lateral distribution at ground level. We find that for cross sections above 20 mb there are regions of parameter space where the two types of showers are essentially indistinguishable. We conclude that the neutrino candidate hypothesis cannot be ruled out on the basis of shower characteristics.Comment: 24 pages, latex, 19 figures; text discussion and references added, typos corrected; figures and conclusions unchange
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