An immunocompetent adult patient with hepatitis and guillain-barré syndrome after cytomegalovirus infection

<p>Abstract</p> <p>Objectives</p> <p>It is to describe an immunocompetent adult patient with hepatitis and Guillain-Barré syndrome (GBS) after Cytomegalovirus (CMV) infection. In the initial course of the diagnosis and treatment, CMV infection was ignored.</p> <p>Case report</p> <p>A 19-year-old Chinese girl complained of fatigue with pain and numbness of the limbs, with abnormal liver function. She was diagnosed as a case of GBS based on history, clinical findings and auxiliary examinations. On day 13 of admission, her liver function was still abnormal. So CMV was recommended to examine. CMV hepatitis was diagnosed on positive serum anti-CMV IgG and IgM antibodies. The case was improved only with intravenous immunoglobulin therapy, without the use of antiviral therapy.</p> <p>Conclusions</p> <p>This case showed an immunocompetent adult patient with hepatitis and GBS induced by CMV. The physicians should take into account multi-system involvement of severe CMV infection.</p

Romeríes del 1320

"Aquestes romeries faeren En P. Riber he En R. Torner en lany de nostre Senyor. M. CCCXX. que anaren a la perdonança de monsenyer sen Ffrancesch de Sis". Transcripció d'aquest manuscrit que es conserva en l'Arxiu de la Comunitat de Santa Maria de Ma

Resistive switching in atomic layer deposited HfO2/ZrO2 nanolayer stacks

The resistive switching properties of HfO2/ZrO2 nanolayers with the total thickness of 16 nm prepared using atomic layer deposition (ALD) were investigated. Current-voltage behavior, pulse time mode measurement, retention and endurance tests were carried out to characterize the memristive (memory-resistive) properties. Resistive switching was observed in all nanolayer stacks, and the set voltage (Vset) decreased with increasing the number of layers (i.e., increasing number of hafnia-zirconia interfaces). Grazing incidence x-ray diffraction (GI-XRD) results demonstrate that the hafnia transforms from monoclinic to orthorhombic crystal structure during the post metallization annealing. Shifts in the binding energy of the x-ray photoelectron spectra (XPS) implies the existence of hafnia and zirconia suboxide (HfO2-δ and ZrO2-δ). Moreover, the blocking nature of the inserted oxide/oxide interfaces serves as a barrier to oxygen ion/vacancy migration. It is shown that memristive/insulating nanostructures like HfO2/ZrO2 can help modulate the resistive switching of memristor-based devices

Male Populus cathayana than female shows higher photosynthesis and less cellular injury through ABA-induced manganese transporting inhibition under high manganese condition

High Mn poisoned male and female Populus cathayana. The toxicity could be alleviated by exogenous ABA application. Intriguingly, ABA granted higher resistance to males than to females under high Mn stress because ABA could induce more blocking of Mn translocation to leaf in males than in females. Abscisic acid (ABA) is involved in plants' adaptive responses to various environmental stresses. However, little is known about the sex-related detoxification of ABA in plants under excess manganese (Mn) conditions. To reveal potentially different ABA detoxification mechanisms between Populus cathayana males and females against excess Mn exposure, photosynthesis performance, Mn2+ concentrations and morphologic changes were investigated. High Mn stress led to a more severe chloroplast destruction and, thus, greater reduction in the photosynthesis of P. cathayana females when compared to males. Under high Mn conditions, Mn reallocated mainly to leaves in females, while in males, it was distributed equally to roots and leaves. With the application of ABA, photosynthesis was restored more in males and more integrated grana in males than in females. It should be noted that Mn concentrations in males were lower in leaves and higher in roots and stems than those in females when treated with the combination of Mn and ABA. Conclusively, due to the reduction of root-shoot Mn transportation induced by ABA in P. cathayana males, males experienced less physiological injuries than do females, which suggest that males possess greater ABA-inducible resistance to Mn stress than do females.Peer reviewe

Self-assembled nanoparticle antiglare coatings

Here we report a simple and scalable bottom-up technology for assembling close-packed nanoparticle monolayers on both sides of a glass substrate as high-quality antiglare coatings. Optical measurements show that monolayer coatings consisting of 110 nm silica nanoparticles can significantly reduce optical reflectance and enhance specular transmittance of the glass substrate for a broad range of visible wavelengths. Both experiments and numerical simulations reveal that the antiglare properties of the self-assembled colloidal monolayers are significantly affected by the size of the colloidal particles

Shen-Fu Injection Preconditioning Inhibits Myocardial Ischemia-Reperfusion Injury in Diabetic Rats: Activation of eNOS via the PI3K/Akt Pathway

The aim of this paper is to investigate whether Shen-fu injection (SFI), a traditional Chinese medicine, could attenuate myocardial ischemia-reperfusion (MI/R) injury in diabetes. Streptozotocin-induced diabetic rats were randomly assigned to the Sham, I/R, SFI preconditioning, and SFI plus wortmannin (a phosphatidylinositol 3-kinase inhibitor) groups. After the treatment, hearts were subjected to 30 min of coronary artery occlusion and 2 h reperfusion except the Sham group. Myocardial infarct size and cardiomyocytes apoptosis were increased significantly in MI/R group as compared with the Sham group. SFI preconditioning significantly decreased infarct size, apoptosis, caspase-3 protein expression, MDA level in myocardial tissues, and plasma level of CK and LDH but increased p-Akt, p-eNOS, bcl-2 protein expression, and SOD activity compared to I/R group. Moreover, SFI-induced cardioprotection was abolished by wortmannin. We conclude that SFI preconditioning protects diabetic hearts from I/R injury via PI3K/Akt-dependent pathway

Adverse events in the treatment of spinal muscular atrophy in children and adolescents with nusinersen: A systematic review and meta-analysis

ObjectivesTo systematically analyze adverse events (AEs) in treatment of spinal muscular atrophy (SMA) with Nusinersen in children and adolescents.MethodsThe study is registered on PROSPERO (CRD42022345589). Databases were searched and literature relating to Nusinersen in the treatment of spinal muscular atrophy in children from the start of database establishment to December 1, 2022, was retrospectively analyzed. R.3.6.3 statistical software was used, and random effects meta-analysis was performed to calculate weighted mean prevalence and 95% confidence intervals (CI).ResultsIn total, 15 eligible studies were included, with a total of 967 children. Rate of definite Nusinersen-related AEs was 0.57% (95% CI: 0%–3.97%), and probable Nusinersen-related AEs 7.76% (95% CI: 1.85%–17.22%). Overall rate of AEs was 83.51% (95% CI: 73.55%–93.46%), and serious AEs 33.04% (95% CI: 18.15%–49.91%). For main specific AEs, fever was most common, 40.07% (95% CI: 25.14%–56.02%), followed by upper respiratory tract infection 39.94% (95% CI: 29.43%–50.94%), and pneumonia 26.62% (95% CI: 17.99%–36.25%).The difference in overall AE rates between the two groups (Nusinersen group and placebo group) was significant (OR = 0.27,95% CI: 0.08–0.95, P = 0.042). Moreover, incidence of serious adverse events, and fatal adverse events were both significantly lower than in the placebo group (OR = 0.47, 95%CI: 0.32–0.69, P &lt; 0.01), and (OR = 0.37, 95%CI: 0.23–0.59, P &lt; 0.01), respectively.ConclusionNusinersen direct adverse events are rare, and it can effectively reduces common, serious, and fatal adverse events in children and adolescents with spinal muscular atrophy