94 research outputs found

    Parental functioning during maintenance treatment for childhood acute lymphoblastic leukemia: Effects of treatment intensity and dexamethasone pulses

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    Background: During maintenance treatment, Dutch pediatric patients with medium-risk (MR) acute lymphoblastic leukemia (ALL) receive intravenous chemotherapy and cyclic dexamethasone. Dexamethasone affects child's sleep and behavior. Standard-risk (SR) patients only receive oral chemotherapy, without dexamethasone. Effects of stratified therapy on parents are not well known. This study compares parental sleep, distress and quality of life (QoL) with the general population, between MR and SR groups, and on- and off-dexamethasone (MR group). Procedure: One year after diagnosis, parents of MR patients completed the Medical Outcomes Study (MOS) sleep, distress thermometer for parents and Short Form-12 (SF-12) twice; once on-dexamethasone and once off-dexamethasone. SR parents completed one measurement. Sleep problems, distress and QoL scores (off-dexamethasone) were compared to reference values and between MR and SR. Score differences on- and off-dexamethasone were assessed by multilevel regression analysis. Results: Parents (80% mothers) of 121 patients (57% males; 75% MR, 25% SR) completed 191 measurements. Compared to reference values, parents reported more sleep disturbances, higher distress, and lower mental QoL. Additionally, MR parents reported clinical distress (score ≥ 4), whereas SR parents (on average) did not (mean 4.8 ± 2.4 vs 3.5 ± 2.4, P =.02). Within the MR group, outcomes did not significantly differ on- and off-dexamethasone. Conclusions: Parents of ALL patients report sleep problems, high distress, and QoL impairment. Within the MR group, parental functioning did not differ on- and off-dexamethasone. However, MR parents reported clinical distress more often than SR parents, possibly reflecting differences in prognostic estimates and treatment burden. This perhaps includes the overall strain of cyclic dexamethasone. This study highlights the need for psychosocial support throughout treatment, regardless of risk stratification

    Chemical abundance of the LINER galaxy UGC 4805 with SDSS-IV MaNGA

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    Chemical abundance determinations in Low-Ionization Nuclear Line Regions (LINERs) are especially complex and uncertain because the nature of the ionizing source of this kind of object is unknown. In this work, we study the oxygen abundance in relation to the hydrogen abundance (O/H) of the gas phase of the UGC 4805 LINER nucleus. Optical spectroscopic data from the Mapping Nearby Galaxies (MaNGA) survey was employed to derive the O/H abundance of the UGC 4805 nucleus based on the extrapolation of the disk abundance gradient, on calibrations between O/H abundance and strong emission-lines for Active Galactic Nuclei (AGNs) as well as on photoionization models built with the Cloudy code, assuming gas accretion into a black hole (AGN) and post-Asymptotic Giant Branch (p-AGB) stars with different effective temperatures. We found that abundance gradient extrapolations, AGN calibrations, AGN and p-AGB photoionization models produce similar O/H values for the UGC 4805 nucleus and similar ionization parameter values. The study demonstrated that the methods used to estimate the O/H abundance using nuclear emission-line ratios produce reliable results, which are in agreement with the O/H values obtained from the independent method of galactic metallicity gradient extrapolation. Finally, the results from the WHAN diagram combined with the fact that the high excitation level of the gas has to be maintained at kpc scales, we suggest that the main ionizing source of the UGC 4805 nucleus probably has a stellar origin rather than an AGN.Fil: Krabbe, Angela. Universidade Do Vale Do Paraíba; BrasilFil: Oliveira, C. B.. Universidade Do Vale Do Paraíba; BrasilFil: Zinchenko, I. A.. Universitat Ulm. Faculty Of Natural Sciences. Institute Of Theoretical Physics; AlemaniaFil: Hernández Jiménez, J. A.. Universidad Andrés Bello; ChileFil: Dors, Oli L.. Universidade Do Vale Do Paraíba; BrasilFil: Hägele, Guillermo Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Cardaci, Monica Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Telles, N. R.. Universidade Do Vale Do Paraíba; Brasi

    The impact of maintenance therapy on sleep-wake rhythms and cancer-related fatigue in pediatric acute lymphoblastic leukemia

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    Purpose: To assess the impact of maintenance therapy and the additional impact of dexamethasone treatment on cancer-related fatigue and sleep-wake rhythms in pediatric acute lymphoblastic leukemia (ALL) patients and to determine the association between these outcomes. Methods: A national cohort of pediatric ALL patients (≥ 2 years) was included (± 1 year post-diagnosis). Patients receiving dexamethasone were assessed twice (assessment with and without dexamethasone). Actigraphy assessments were used to calculate sleep-wake outcomes with nonparametric methods. Cancer-related fatigue was assessed with the PedsQL Multidimensional Fatigue Scale. Sleep-wake rhythms and cancer-related fatigue were compared between patients participating in the assessment without dexamethasone and healthy children (linear regression) and between assessments with and without dexamethasone (mixed models). Using linear regression, associations between sleep-wake outcomes and cancer-related fatigue were determined during assessments with and without dexamethasone. Results: Responses were collected for 125 patients (113 assessments with and 81 without dexamethasone). The sleep-wake rhythm was less stable (p = 0.03) and less robust (p = 0.01), with lower physical activity l

    Diagnostic diagrams for ram-pressure stripped candidates

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    This paper presents a method for finding ram-pressure stripped (RPS) galaxy candidates by performing a morphological analysis of galaxy images obtained from the Legacy survey. We consider a sample of about 600 galaxies located in different environments such as groups and clusters, tidally interacting pairs and the field. The sample includes 160 RPS previously classified in the literature into classes from J1 to J5, based on the increasing level of disturbances. Our morphological analysis was done using the {\sc astromorphlib} software followed by the inspection of diagnostic diagrams involving combinations of different parameters like the asymmetry (AA), concentration (CC), S\'ersic index (nn), and bulge strength parameters F(G,M20)F(G,\,M_{20}). We found that some of those diagrams display a distinct region in which galaxies classified as J3, J4 and J5 decouples from isolated galaxies. We call this region as the morphological transition zone and we also found that tidally interacting galaxies in pairs are predominant within this zone. Nevertheless, after visually inspecting the objects in the morphological transition zone to discard obvious contaminants, we ended up with 33 bonafide new RPS candidates in the studied nearby groups and clusters (Hydra, Fornax, and CLoGS sample), of which one-third show clear evidence of unwinding arms. Future works may potentially further increase significantly the samples of known RPS using such method.Comment: 17 pages, 9 figure

    Gas phase metallicity determinations in nearby AGNs with SDSS-IV MaNGA: evidence of metal poor accretion

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    We derive the metallicity (traced by the O/H abundance) of the Narrow Line Region ( NLR) of 108 Seyfert galaxies as well as radial metallicity gradients along their galaxy disks and of these of a matched control sample of no active galaxies. In view of that, observational data from the SDSS-IV MaNGA survey and strong emission-line calibrations taken from the literature were considered. The metallicity obtained for the NLRs %each Active Galactic Nucleus (AGN) was compared to the value derived from the extrapolation of the radial oxygen abundance gradient, obtained from \ion{H}{ii} region estimates along the galaxy disk, to the central part of the host galaxies. We find that, for most of the objects (80%\sim 80\,\%), the NLR metallicity is lower than the extrapolated value, with the average difference ()betweentheseestimatesrangingfrom0.16to0.30dex.Wesuggestthat) between these estimates ranging from 0.16 to 0.30 dex. We suggest that is due to the accretion of metal-poor gas to the AGN that feeds the nuclear supermassive black hole (SMBH), which is drawn from a reservoir molecular and/or neutral hydrogen around the SMBH. Additionally, we look for correlations between DD and the electron density (NeN_{\rm e}), [\ion{O}{iii}]λ\lambda5007 and Hα\alpha luminosities, extinction coefficient (AV)A_{V}) of the NLRs, as well as the stellar mass (MM_{*}) of the host galaxies. Evidences of an inverse correlation between the DD and the parameters NeN_{\rm e}, MM_{*} and AvA_{\rm v} were found

    Gas-phase metallicity determinations in nearby AGNs with SDSS-IV MaNGA : evidence of metal-poor accretion

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    We derive the metallicity (traced by the O/H abundance) of the narrow-line region (NLR) of 108 Seyfert galaxies as well as radial metallicity gradients along their galaxy discs and of these of a matched control sample of no active galaxies. In view of that, observational data from the SDSS-IV MaNGA survey and strong emission-line calibrations taken from the literature were considered. The metallicity obtained for the NLRs was compared to the value derived from the extrapolation of the radial oxygen abundance gradient, obtained from H II region estimates along the galaxy disc, to the central part of the host galaxies. We find that, for most of the objects (∼ 80 per cent), the NLR metallicity is lower than the extrapolated value, with the average difference ( D ) between these estimates ranging from 0.16 to 0.30 dex. We suggest that D is due to the accretion of metal-poor gas to the AGN that feeds the nuclear supermassive black hole (SMBH), which is drawn from a reservoir molecular and/or neutral hydrogen around the SMBH. Additionally, we look for correlations between D and the electron density (Ne), [O III]λ5007, and H α luminosities, extinction coefficient (AV) of the NLRs, as well as the stellar mass (M∗) of the host galaxies. Evidence of an inverse correlation between the D and the parameters Ne, M∗, and Av was found

    Emirical calibration for helium abundance determinations in active galactic nuclei

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    For the first time, a calibration between the He I λ5876/Hβ emission line ratio and the helium abundance y = 12 + log(He/H) for Narrow line regions of Seyfert 2 Active Galactic Nuclei is proposed. In this context, observational data (taken from the SDSS-DR15 and from the literature) and direct abundance estimates (via the Te-method) for a sample of 65 local ( z −2.0).Fil: Dors, Oli L.. Universidade Do Vale Do Paraíba; BrasilFil: Almeida Gouvea, Celine. Universidade Do Vale Do Paraíba; BrasilFil: Oliveira, C. B.. Universidade Do Vale Do Paraíba; BrasilFil: Flury, S. R.. University of Massachusetts Amherst; Estados UnidosFil: Riffel, Romina Elisabet. Universidade Federal do Rio Grande do Sul; BrasilFil: Riffel, R. A.. Universidade Federal de Santa Maria; BrasilFil: Cardaci, Monica Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Hägele, Guillermo Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Ilha, G. S.. Universidade do Sao Paulo. Instituto de Astronomia, Geofísica e Ciências Atmosféricas; Brasil. Universidade de Sao Paulo; BrasilFil: Krabbe, A. C.. Universidade do Sao Paulo. Instituto de Astronomia, Geofísica e Ciências Atmosféricas; Brasil. Universidade de Sao Paulo; BrasilFil: Arellano Córdova, K. Z.. University of Edinburgh; Reino UnidoFil: Santos, P. C.. Universidade do Vale do Paraíba; BrasilFil: Morais, I. N.. Universidade do Vale do Paraíba; Brasi
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