Prevalence and Incidence of HCV Infection among Prisoners in Central Brazil

Submitted by Sandra Infurna ([email protected]) on 2017-05-04T13:09:43Z No. of bitstreams: 1 barbara_lago_etal_IOC_2017.pdf: 2294511 bytes, checksum: d3e34b2cddbbe7813fed3a35ecb9cb2e (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2017-05-04T13:22:45Z (GMT) No. of bitstreams: 1 barbara_lago_etal_IOC_2017.pdf: 2294511 bytes, checksum: d3e34b2cddbbe7813fed3a35ecb9cb2e (MD5)Made available in DSpace on 2017-05-04T13:22:45Z (GMT). No. of bitstreams: 1 barbara_lago_etal_IOC_2017.pdf: 2294511 bytes, checksum: d3e34b2cddbbe7813fed3a35ecb9cb2e (MD5) Previous issue date: 2017Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Mato Grosso do Sul, MS. Brasil / Universidade Federal do Grande Dourados. Mato Grosso do Sul, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal de Goiás. Escola de Enfermagem. Goiânia, GO, Brasil.Universidade Federal do Grande Dourados.. Mato Grosso do Sul, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal do Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Mato Grosso do Sul, MS, Brasil.The aim of this multicenter, cross sectional study was to assess the prevalence, incidence and associated risk factors among incarcerated populations from twelve Brazilian prisons. The total of 3,368 individuals from twelve prisons was randomly recruited between March 2013 and March 2014. Participants were interviewed, and provided blood samples which were tested for antibodies to Hepatitis C (HCV ab). One year after the first investigation, a cohort study was conducted with 1,656 inmates who participated the cross sectional study. Positive samples were tested for the presence of HCV RNA. Out of 3,368 inmates, 520 (15.4%) were females, and 2,848 (84.6%) were males. The overall prevalence of HCV was 2.4% (95% CI: 1.9 to 2.9), with 0.6% (95% CI: 0.4 to 0.8) in females, and 2.7% (95% CI: 2.1 to 3.3) in males (p<0.01). HCV RNA was detected in 51/80 (63.7%) samples. Among men prisoners, multivariate analysis of associated factors showed independent associations between HCV exposure and increasing age, inject drug use, length of incarceration, smoking hashish, sharing needle and syringe and HIV positivity. During the cohort study, 7/1,656 new cases of HCV infection were detected, and the incidence rate was 0.4/100 person-year. Once high frequency rates of specific HCV risk behaviors and new HCV infections have been identified inside prisons, effective interventions strategies such as screening, clinical evaluation and treatment to reduce the spread of HCV infection are essential

Univariable regression analysis of risk factors associated with HCV prevalence among male prisoners at baseline (n = 2,848).

<p>Univariable regression analysis of risk factors associated with HCV prevalence among male prisoners at baseline (n = 2,848).</p

Flow chart of the recruitment of the study and screening process for HCV.

<p>Flow chart of the recruitment of the study and screening process for HCV.</p

Multivariable regression analysis of risk factors associated with HCV infection in male prisoners at baseline (n = 77).

<p>Multivariable regression analysis of risk factors associated with HCV infection in male prisoners at baseline (n = 77).</p

Geographical location of study prisons, Mato Grosso do Sul, Brazil (Adapted from reference 10).

<p>Geographical location of study prisons, Mato Grosso do Sul, Brazil (Adapted from reference 10).</p