Resurrecting the Role of Real Money Balance Effects

I present a structural econometric analysis supporting the hypothesis that money is still relevant for shaping inflation and output dynamics in the United States. In particular, I find that real money balance effects are quantitatively important, although smaller than they used to be in the early postwar period. Moreover, I show three additional implications of the econometric estimates for monetary policy analysis. First, by including real money balance effects into the standard sticky price model, two stylized facts can be explained: the modestly procyclical real wage response to a monetary policy shock and the supply side effects of monetary policy. Second, the existence of real money balance effects causes higher volatility of output and lower volatility of interest rates under the optimal monetary policy. Third, the reduction in the size of real money balance effects can account for a significant decline in macroeconomic volatility.Business fluctutations and cycles, Monetary aggregates, Transmission of monetary policy

Introducing Multiple Interest rates in ToTEM

This article describes changes to the structure of ToTEM—the Bank of Canada’s main model for projection and policy analysis—that allow an independent role for long-term interest rates, as well as for the risk spreads that lead to differences in the interest rates faced by households, firms and the government. These changes broaden the range of policy questions that the model can address and improve its ability to explain data. The authors use the model to simulate the effects of shocks to the risk spreads on interest rates similar to those that occurred during the recent financial crisis. They also use the model to assess the macroeconomic impact of higher requirements for bank capital and liquidity.

Magnetic states of linear defects in graphene monolayers: effects of strain and interaction

The combined effects of defect-defect interaction and of uniaxial or biaxial strains of up to 10\% on the development of magnetic states on the defect-core-localized quasi-one-dimensional electronic states generated by the so-called 558 linear extended defect in graphene monolayers are investigated by means of {\it ab initio} calculations. Results are analyzed on the basis of the heuristics of the Stoner criterion. We find that conditions for the emergence of magnetic states on the 558 defect can be tuned by uniaxial tensile parallel strains (along the defect direction) at both limits of isolated and interacting 558 defects. Parallel strains are shown to lead to two cooperative effects that favor the emergence of itinerant magnetism: enhancement of the DOS of the resonant defect states in the region of the Fermi level and tuning of the Fermi level to the maximum of the related DOS peak. A perpendicular strain is likewise shown to enhance the DOS of the defect states, but it also effects a detunig of the Fermi level that shifts away from the maximum of the DOS of the defect states, which inhibts the emergence of magnetic states. As a result, under biaxial strains the stabilization of a magnetic state depends on the relative magnitudes of the two components of strain.Comment: 9 pages 8 figure

ICF Linking of Patient-Reported Therapy Goals for Children with Acquired Upper Extremity Impairment

BACKGROUND: Patient reported outcome measures are used to evaluate hand therapy outcomes. Yet, limited evidence is available regarding the outcomes children desire from hand therapy. PURPOSE: To determine the desired treatment outcomes of children with acquired upper extremity impairments. STUDY DESIGN: Descriptive case series METHODS: Two raters independently applied International Classification of Function, Disability and Health (ICF) linking rules to the Canadian Occupational Performance goals of 151 children, age 6-18, receiving occupational therapy for acquired upper extremity impairments. Prevalence of the linked ICF codes was examined using frequency distributions. Kappa and the proportion of positive agreement assessed inter-rater agreement of the linked codes. RESULTS: Following consensus, two independent raters linked 894 meaningful concepts to the study population\u27s 501 goals derived from the Canadian Occupational Performance. Ninety-two unique ICF codes were linked to these 894 meaningful concepts. Twenty-three ICF codes account for 77.2% of the most frequently linked codes. For these top 23 codes, the greatest proportion (51.4%) of ICF codes are in the d4 mobility chapter representing specific constructs of hand and arm use. The second largest proportion (14.2%) of linked codes are in the d9 Community, society and civic life chapter aligning with participation in sports, music, performing arts and play. Within the d5 self-care chapter, the study population\u27s top priorities included hair care, fitness and drinking. The primary concerns within the b body functions domain are reduced pain, improved joint mobility and strength. CONCLUSION: The study population\u27s top priorities align with specific dimensions of hand and arm use and participation in sports and fitness, performing arts, and play. Further research may elucidate alignment of these patient-desired outcomes and the item banks of commonly used patient reported outcome measurement scales in this population

Progrès vers la synthèse totale de la Pactamycine

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Synthèse totale de la pactamycine et d’une sélection d’analogues, progrès vers la synthèse totale de la daphniglaucine C et brève étude d’une transposition allylique réductrice

Il y a plus de cinquante ans, la pactamycine a été isolée en tant qu’agent antitumoral potentiel. Il a été réalisé plus tard qu’il s’agissait en fait d’un agent antibactérien capable d’inhiber la synthèse de protéines lors du procédé de traduction. Récemment, il a même été démontré que certains de ses analogues possèdent des propriétés antiprotozoaires prometteuses. La présente thèse détaille la première synthèse totale de la pactamycine, entreprise au sein du groupe Hanessian, ainsi que la préparation d’une sélection d’analogues testés pour leurs propriétés biologiques. En outre, la daphniglaucine C appartient à une vaste famille de composés naturels isolés des feuilles du daphniphyllum au cours des dix dernières années. Bien que relativement peu d’information soit connue par rapport à l’activité biologique de la daphniglaucine C, la synthèse de celle-ci représente certainement un défi intéressant pour un chimiste organicien. Au passage, nos efforts vers la synthèse totale du composé cible auront permis d’explorer l’emploi de plusieurs méthodes en vue de la formation de centres quaternaires. De plus, un réarrangement réductif atypique, catalysé au palladium à partir d’alcools allyliques non-activés, a été étudié et employé afin de générer une sélection de pyrrolidines polysubstituées.Although pactamycin was first isolated as a potential antitumoral drug, further studies highlighted its capacities in inhibiting protein synthesis, and thus its potency as an antibacterial agent. Furthermore, it was recently discovered that some of its analogs display promising antiprotozoal activity. The present thesis reports and details the first total synthesis of pactamycin, pursued in the Hanessian lab over the last few years, as well as the preparation of a selection of analogs thereby tested for their biological properties. Daphniglaucin C belongs to a large family of natural compounds isolated from the leaves of daphniphyllum over the last decade. Although relatively little is known as to the biological activity of daphniglaucin C, its synthesis poses an obvious and interesting challenge for organic chemists. En route towards its total synthesis, the use of several methods for the formation of quaternary centers was explored. Moreover, an atypical reductive allylic transposition, catalyzed by palladium from unactivated allylic alcohols, was studied and used to generate a variety of polysubstituted pyrrolidines

Prevalence of Depression in Gynecologic and Breast Cancer Patients Authors

Objective Depression has historically been an underdiagnosed and undertreated condition with a large impact on patient quality of life. Screening and diagnosis of depression may differ for various reasons, making proper diagnosis and treatment difficult. Methods In this retrospective cohort study, we analyzed the associations between the prevalence of depression and patient-specific factors in gynecologic and breast cancer patients who had received a palliative care consult. This study was conducted in a single institution that specializes in women and infant care. The primary objective was to quantify the prevalence of depression among palliative care patients. The secondary objective was to determine patient specific factors associated with a diagnosis of depression. Results Over the course of the one year inclusion period, a total of 73 patients met inclusion criteria. The prevalence of depression in this study was found to be 54.8%. A diagnosis of anxiety was associated with the presence of depression (77.5% vs 25%, p \u3c 0. 0001). Cancer of the fallopian tube was also independently associated with depression (12. 5% vs 0, p = 0. 44). Conclusion The prevalence of depression for palliative care patients, specifically for patients with gynecologic and breast malignancies, in this study was higher than estimates of depression prevalence for the general population. The results of this study may indicate that a greater awareness of the need for screening and treatment of depression is necessary in this population, in order to properly diagnose and treat patients with depression

Gestión administrativa y desempeño laboral de trabajadores Empresa Hermes Transportes Blindados Huacho, 2020

La investigación titulada \"Gestión Administrativa y Desempeño Laboral de los trabajadores empresa Hermes Transportes blindados Huacho, 2020\" su objetivo fue determinar la relación que existe entre la Gestión Administrativa y el desempeño laboral de los trabajadores empresa Hermes Transportes blindados Huacho, 2020?. Dicho estudio fue de tipo descriptivo correlacional, transversal y de enfoque cuantitativo. La técnica utilizada fue la encuesta y el instrumento el cuestionario que se aplicó a una población muestra de 72 trabajadores de la empresa Hermes Transporte . En conclusión se demostró que la Gestión Administrativa que se desarrolla en la empresa Hermes Transporte blindado Huacho, 2020 promueve el buen desempeño de sus trabajadores con un coeficiente de Spearman de 0,846 y un valor de la significancia bilateral 0,00 mayor que 0,05.Tesi

Comportamiento social y escenarios urbanos en la avenida Los Olivos, Urbanización Miguel Grau, San Martín de Porres, 2016 – 2021

El comportamiento social siempre se encuentra en un estado de constante cambio, el ser humano atraviesa distintas etapas en las cuáles su conducta varía, así mismo se observa que este proceder va de la mano con los escenarios en los que se desenvuelven, en el que es uno de los protagonistas. Por tanto, para entender mejor este fenómeno se tiene como objetivo general analizar de qué manera el comportamiento social influye en los escenarios urbanos. La presente investigación se desarrolla bajo un enfoque cualitativo y de corte longitudinal, ya que, los datos recolectados corresponden a sucesos de los últimos cinco años. Como resultado se precisó que la formación, evolución y características de los tres escenarios urbanos que se presentan en diferentes franjas horarias del día, está determinado por el comportamiento de las personas en el lugar, son los actores quiénes definen las actividades debido a la demanda que generan. De esta manera, demostramos que, debido a la influencia del comportamiento social en los escenarios urbanos, éste es un factor determinante para la composición de los mismo