6 research outputs found
Efficacy and safety of tocilizumab and baricitinib among patients hospitalized for COVID-19: a systematic review and meta-analysis
Introduction: Tocilizumab and baricitinib are recommended treatment options for COVID-19 patients with hyperinflammatory response; however, there is a lack of systematic review directly evaluating their efficacy and safety.Objective: This review was conducted to evaluate the efficacy and safety of tocilizumab and baricitinib in the treatment of hospitalized patients with COVID-19.Methods: Relevant databases were searched for studies that compared the effect or safety of baricitinib or tocilizumab in hospitalized patients with COVID-19. The mortality was the main outcome. The hospital length of stay or adverse drug reactions were taken into consideration as secondary endpoints. The analyses were performed in Revman 5.3 or Stata 16.0. The protocol and analysis plan were pre-registered in PROSPERO, with the registration number CRD42023408219.Results: In total, 10 studies with 2,517 patients were included. The overall pooled data demonstrated that, there was no statistically significant difference in the 28-day mortality rate and the hospital length of stay between the tocilizumab and baricitinib (OR = 1.10, 95% CI = 0.80–1.51, p = 0.57; OR = −0.68, 95% CI = −2.24–0.87, p = 0.39). The adverse reactions including secondary infection rate, thrombotic and bleeding events, and acute liver injury of tocilizumab were significantly higher than that of baricitinib. (OR = 1.49, 95% CI = 1.18–1.88, p < 0.001,OR = 1.52, 95% CI = 1.11–2.08, p = 0.009; OR = 1.52, 95% CI = 1.11–2.08, p = 0.009; OR = 2.24, 95% CI = 1.49–3.35, p < 0.001).Conclusion: In patients hospitalized with COVID-19, no discernible difference in therapeutic efficacy was observed between tocilizumab and baricitinib; however, the group treated with baricitinib demonstrated a significantly lower incidence of adverse effects
High miR-3648 expression and low APC2 expression are associated with shorter survival and tumor progression in NSCLC
Background. Emerging studies have
demonstrated that microRNAs (miRNAs) play crucial
roles in the carcinogenesis of many developing human
tumors. However, the clinical significance and biological
function of microRNA-3648 (miR-3648) in non-small
cell lung cancer (NSCLC) have been largely undefined.
Methods. The expression of miR-3648 and the
mRNA of adenomatous polyposis coli 2 (APC2) in
NSCLC tissues and cell lines were analyzed using
quantitative real-time RT-PCR. The prognostic value of
miR-3648 and APC2 was examined using the KaplanMeier method and Cox regression analyses. Experiments
using NSCLC cells were conducted to explore the
influences of miR-3648 on tumor cell proliferation,
migration and invasion.
Result. Increased expression of miR-3648 was
observed in NSCLC tissues and cell lines compared with
the corresponding controls (all P<0.05). miR-3648
expression was associated with the differentiation,
lymph node metastasis and TNM stage (all P<0.05) of
NSCLC patients, and high expression of miR-3648 was
associated with poor overall survival rate. NSCLC cell
proliferation, migration and invasion were significantly
enhanced by miR-3648 overexpression. The further
luciferase reporter assay and expression results showed
that the decreased APC2 might also be a prognostic
biomarker, and served as a target of miR-3648 in
NSCLC.
Conclusion. The findings from the present study
indicate that the overexpression of miR-3648 serves as a
useful biomarker for the prediction of prognosis in
NSCLC, and promotes tumor cell proliferation,
migration and invasion. APC2, as another prognosisrelated molecule, may be a target of miR-3648 in
NSCLC