492 research outputs found
The End of Modernism
Nobel laureate Elias Canetti wrote his novel "Auto-da-Fé" ("Die Blendung") when he and the twentieth century were still quite young. Rooted in the cultural crises of the Weimar period, "Auto-da-Fé" first received critical acclaim abroad—in England, France, and the United States—where it continues to fascinate readers of subsequent generations. "The End of Modernism" places this work in its cultural and philosophical contexts, situating the novel not only in relation to Canetti's considerable body of social thought, but also within larger debates on Freud and Freudianism, misogyny and modernism's "fragmented subject," anti-Semitism and the failure of humanism, contemporary philosophy and philosophical fads, and traditionalist notions of literature and escapist conceptions of history. "The End of Modernism" portrays "Auto-da-Fé" as an exemplum of "analytic modernism," and in this sense a crucial endpoint in the progression of postwar conceptions of literary modernism
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Low-Dose Continuous 5-Fluorouracil Combined with Leucovorin, nab-Paclitaxel, Oxaliplatin, and Bevacizumab for Patients with Advanced Pancreatic Cancer: A Retrospective Analysis.
BackgroundContinuous-infusion 5-fluorouracil (5FU) and calcium leucovorin plus nab-paclitaxel and oxaliplatin have been shown to be active in patients with pancreatic cancer. As a protracted low-dose infusion, 5FU is antiangiogenic, and has synergy with bevacizumab. As shown in the treatment of breast cancer, bevacizumab and nab-paclitaxel are also synergetic.ObjectiveIn this paper we retrospectively analyze the survival of 65 patients with advanced pancreatic cancer who were treated with low-dose continuous (metronomic) chemotherapy given in conjunction with conventional anti-VEGF therapy.Patients and methodsSince July of 2008, we have treated 65 patients with 5FU (180Â mg/m2/day Ă— 14Â days) via an ambulatory pump. Calcium leucovorin (20Â mg/m2 IV), nab-paclitaxel (60Â mg/m2) IV as a 30-min infusion, and oxaliplatin (50Â mg/m2) IV as a 60-min infusion were given on days 1, 8, and 15. Bevacizumab (5Â mg/kg) IV over 30Â min was administered on days 1 and 15. Cycles were repeated every 28-35Â days. There were 42 women and 23 men, and the median age was 59 years. Forty-six patients had stage IV disease.ResultsThe median survival was 19Â months, with 82% of patients surviving 12Â months or longer. The overall response rate was 49%. There were 28 patients who had received prior treatment, 15 of whom responded to therapy. Fifty-two patients had elevated CA 19-9 prior to treatment. Of these, 21 patients had 90% or greater reduction in CA 19-9 levels. This cohort had an objective response rate of 71% and a median survival of 27Â months. Thirty patients stopped treatment due to disease progression, and an additional 22 stopped because of toxicity. One patient died while on therapy.ConclusionsThis non-gemcitabine-based regimen resulted in higher response rates and better survival than what is commonly observed with therapy given at conventional dosing schedules. Low-dose continuous (metronomic therapy) cytotoxic chemotherapy combined with antiangiogenic therapy is safe and effective
Test Anxiety: Mathematics and Students with Disabilities
When a test is announced in class some secondary students\u27 experience anxiety. The author of this research investigated twenty-two special education students and the effectiveness of reducing student test anxiety by offering review sessions. These review sessions were voluntary and conducted after school by a special education teacher. Students completed a survey after attending the review session, ninety-four percent reported they felt confident by the end of the session and sixty-nine percent reported that they felt prepared. Other results from this study show the effectiveness of the review session, future studies repeat this study but could benefit from a larger sample size
Radiating Bondi and Cooling Site Flows
Steady accretion of a radiating gas onto a central mass point is described
and compared to classic Bondi accretion. Radiation losses are essential for
accretion flows to be observed. Unlike Bondi flows, radiating Bondi flows pass
through a sonic point at a finite radius and become supersonic near the center.
The morphology of all radiating Bondi flows is described by a single
dimensionless parameter. In radiating Bondi flows the mass accretion rate
varies approximately as the first power of the central mass -- this differs
significantly from the quadratic dependence on the central mass in classical
Bondi flows. Mass accretion rates onto galaxy or cluster-centered black holes
estimated from traditional and radiating Bondi flows are significantly
different. In radiating Bondi flows the gas temperature increases at large
radii, as in the cores of many galaxy groups and clusters, allowing radiating
Bondi flows to merge naturally with gas arriving from their cluster
environments. Some radiating flows cool completely before reaching the center
of the flow, and this also occurs in cooling site flows in which there is no
central gravitating mass.Comment: 9 pages with 3 figures; accepted by Ap
The End of Modernism: Elias Canetti's "Auto-da-FĂ©"
Nobel laureate Elias Canetti wrote his novel "Auto-da-Fé" ("Die Blendung") when he and the twentieth century were still quite young. Rooted in the cultural crises of the Weimar period, "Auto-da-Fé" first received critical acclaim abroad—in England, France, and the United States—where it continues to fascinate readers of subsequent generations. "The End of Modernism" places this work in its cultural and philosophical contexts, situating the novel not only in relation to Canetti's considerable body of social thought, but also within larger debates on Freud and Freudianism, misogyny and modernism's "fragmented subject," anti-Semitism and the failure of humanism, contemporary philosophy and philosophical fads, and traditionalist notions of literature and escapist conceptions of history. "The End of Modernism" portrays "Auto-da-Fé" as an exemplum of "analytic modernism," and in this sense a crucial endpoint in the progression of postwar conceptions of literary modernism
Recent Decisions
Comments on recent decisions by William F. Donahue, Frank G. Matavovsky, Thos. L. McKevitt, Joseph Kirincich, and Maurice W. Lee
Panel: Practising IS Research in Medical Practice: Opportunities and Dilemmas for Rigour and Relevance in Health IT Research
Two Clusters with Radio-quiet Cooling Cores
Radio lobes inflated by active galactic nuclei at the centers of clusters are
a promising candidate for halting condensation in clusters with short central
cooling times because they are common in such clusters. In order to test the
AGN-heating hypothesis, we obtained Chandra observations of two clusters with
short central cooling times yet no evidence for AGN activity: Abell 1650 and
Abell 2244. The cores of these clusters indeed appear systematically different
from cores with more prominent radio emission. They do not have significant
central temperature gradients, and their central entropy levels are markedly
higher than in clusters with stronger radio emission, corresponding to central
cooling times ~ 1 Gigayear. Also, there is no evidence for fossil X-ray
cavities produced by an earlier episode of AGN heating. We suggest that either
(1) the central gas has not yet cooled to the point at which feedback is
necessary to prevent it from condensing, possibly because it is conductively
stabilized, or (2) the gas experienced a major heating event Gyr in
the past and has not required feedback since then. The fact that these clusters
with no evident feedback have higher central entropy and therefore longer
central cooling times than clusters with obvious AGN feedback strongly suggests
that AGNs supply the feedback necessary to suppress condensation in clusters
with short central cooling times.Comment: ApJ Letter, in pres
Nebraska\u27s Economic Future
Nebraskans like where they live. Young and old, they like the
“sense of place” they feel here. They like being part of the legendary
work ethic. They like the fact that, for the most part, they
feel safe here. They like the fact that Nebraska agriculture helps
to feed and power the world.
But when people from other states ask them where they’re
from, they sound apologetic. The Strategic Discussions for
Nebraska team heard variations on that theme everywhere we
went. Caleb Pollard, Executive Director of the Ord Chamber of
Commerce said it best: “we need for Nebraskans to be proud.”
Nebraska is a conservative state, both politically and fiscally.
It is constitutionally required to balance the state budget. It is
also a state with only 1.7 million people, so there are few people
to share the property tax burden. Additionally, Nebraska doesn’t
have mineral resources that some states tax heavily, relieving the
property tax burden on individuals. However, Nebraska’s sales
and income taxes are about the same as its peer states, a fact that
is often overlooked when people share concerns about taxes.
One of the state’s main concerns is the declining work force,
particularly in greater Nebraska. This magazine contains several
stories that refer to the work force shortage and the challenges
faced by communities that desperately need workers.
Nebraska’s Strong Agricultural Base
Agriculture has changed in the last century, but it’s a booming
business and Nebraskans are knowledgeable about those
changes. They know the state is well-suited to growing highquality
crops and animals, and they know people in the rest of
the world want to buy them. They know the University of Nebraska’s
research has been important for Nebraska agriculture,
and they support the University of Nebraska-Lincoln’s Nebraska
Innovation Campus, which will be built in Lincoln on the site of
the Nebraska State Fair when the fair moves to Grand Island in
2010.
Nebraska exported nearly 3.6
billion in 2006 and $4.2 billion in 2007. According to Greg
Ibach, Director of the Nebraska Department of Agriculture,
exports bring the state a steady flow of domestic and international
sales and allow the state to remain strong during financial
cycles that affect the U.S. and other countries. Nebraska
is fortunate to have not only the natural resources to produce
some of the best agricultural products – and can source
the needed parts and material for the manufactured products
– but also has the people with the needed background,
knowledge, experience and work ethic to produce the quality
products, Ibach said.
Importance of Education and Technology
There are no greater proponents of education than people in
greater Nebraska. The state’s education system is good and is
one of the drawing cards for businesses interested in locating
in the state.
Nebraskans know that jobs today and in the future will require
more knowledge of technology in all its forms. Whether
people work in information technology in Omaha, farm near
Cozad, ranch near Mullen, read x-rays in Ord, work on locomotives
in Alliance or conduct research in one of dozens of
locations in the state, they’ll have to know technology.
Technology requires consistent broadband access and
capacity that statewide, Nebraska just doesn’t have. A conversation
participant who lives outside North Platte told us
her satellite gives her access to the Internet “as long as it isn’t
cloudy.” That isn’t good enough for the needs of rural health
care, business development, education or for attracting young
people to smaller communities.
Infrastructure
If a state doesn’t have good infrastructure, it closes doors to
economic development and therefore, growth.
Infrastructure necessary for every viable community includes
water, sewer, electricity, roads and Internet access. Additional
infrastructure needs are schools, health care facilities,
power plants, transportation and communication.
It’s expensive to build these things and expensive to maintain
existing facilities. Dr. Doug Kristensen, Chancellor of the
University of Nebraska-Kearney, told us many of the state’s
school buildings were built about the same time – about 100
years ago – and are beginning to crumble, requiring extensive
and costly repairs or replacement.
Changing Nebraska’s Layout?
The Strategic Discussions for Nebraska team interviewed
a number of people who believe Nebraska should change its
county structure.
Ninety-three counties were needed when people had to use
a horse and buggy to get to the county seat, but some say the
state could save money if the counties were merged, creating
about 15 larger counties. Others say there would be few dollars
in savings and would widen the gap between greater Nebraska
and eastern Nebraska in accessibility to services.
Others suggest a “hub and spoke” regional layout, in which
one town would be the hub and about 10 or 12 smaller communities
would be the spokes. Trouble is, everybody wants to
be the hub.
What makes the most sense? Send your opinion to me at
[email protected]. We’ll post the results on the Strategic Discussions
for Nebraska website: www.unl.edu/sdn.
Leadership and Cooperation
People told us the state and communities need strong leaders
who are willing to partner with other organizations, communities,
states and countries for the good of Nebraska as a
whole. It also needs leaders who will consider the needs of the
entire state, regardless of money, power or special interests.
In this magazine, you will find a variety of perspectives on
Nebraska’s economy, including the opinions of state and community
leaders, academics, business owners and government
officials. Each opinion has value, based on the person’s experience,
education, location and economic condition
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