143 research outputs found
Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes
Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001âCVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001âCVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001âCVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD
Ruminococcal cellulosome systems from rumen to human
This article is protected by copyright. All rights reserved. The authors appreciate the kind assistance of Miriam Lerner (ImmunArray Ltd. Company, Rehovot, Israel) with experiments involving the MicroGrid II arrayer. This research was supported by a grant (No. 1349) to EAB also from the Israel Science Foundation (ISF) and a grant (No. 24/11) issued to RL by The Sidney E. Frank Foundation also through the ISF. Additional support was obtained from the establishment of an Israeli Center of Research Excellence (I-CORE Center No. 152/11) managed by the Israel Science Foundation, from the United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel, by the Weizmann Institute of Science Alternative Energy Research Initiative (AERI) and the Helmsley Foundation. The authors also appreciate the support of the European Union, Area NMP.2013.1.1-2: Self-assembly of naturally occurring nanosystems: CellulosomePlus Project number: 604530 and an ERA-IB Consortium (EIB.12.022), acronym FiberFuel. HF and SHD acknowledge support from the Scottish Government Food Land and People programme and from BBSRC grant no. BB/L009951/1. In addition, EAB is grateful for a grant from the F. Warren Hellman Grant for Alternative Energy Research in Israel in support of alternative energy research in Israel administered by the Israel Strategic Alternative Energy Foundation (I-SAEF). E.A.B. is the incumbent of The Maynard I. and Elaine Wishner Chair of Bio-organic ChemistryPeer reviewedPostprin
Three-centre cluster structure in 11C and 11B
Studies of the 16O(9Be,alpha 7Be)14C, 7Li(9Be,alpha 7Li)5He and 7Li(9Be,alpha
alpha t)5He reactions at E(beam)=70 and 55 MeV have been performed using
resonant particle spectroscopy techniques. The 11C excited states decaying into
alpha+7Be(gs) are observed between 8.5 and 13.5 MeV. The alpha+7Li(gs),
alpha+7Li*(4.652 MeV) and t+8Be(gs) decays of 11B excited states between 9 and
19 MeV are observed. The decay processes are used to indicate the possible
three-centre 2alpha+3He (2alpha+3H) cluster structure of observed states. This
cluster structure is more prominent in the positive-parity states, where two
rotational bands with large deformations are suggested. Excitations of some of
the observed T=1/2 resonances coincide with the energies of previously measured
T=3/2 isobaric analogs of the 11Be states,indicating that these states may have
mixed isospin.Comment: Contribution for the proceedings of the NUSTAR'05: NUclear STructure,
Astrophysics and Reactions, University of Surrey, Guildford, UK; accepted for
publication in Journal of Physics
Light-particle emission from the fissioning nuclei 126Ba, 188Pt and (266,272,278)/110: theoretical predictions and experimental results
We present a comparison of our model treating fission dynamics in conjunction
with light-particle (n, p, alpha) evaporation with the available experimental
data for the nuclei 126Ba, 188Pt and three isotopes of the element Z=110. The
dynamics of the symmetric fission process is described through the solution of
a classical Langevin equation for a single collective variable characterizing
the nuclear deformation along the fission path. A microscopic approach is used
to evaluate the emission rates for pre-fission light particles.
Entrance-channel effects are taken into account by generating an initial spin
distribution of the compound nucleus formed by the fusion of two deformed
nuclei with different relative orientations
Coincidence measurement of residues and light particles in the reaction 56Fe+p at 1 GeV per nucleon with SPALADIN
The spallation of Fe in collisions with hydrogen at 1 A GeV has been
studied in inverse kinematics with the large-aperture setup SPALADIN at GSI.
Coincidences of residues with low-center-of-mass kinetic energy light particles
and fragments have been measured allowing the decomposition of the total
reaction cross-section into the different possible de-excitation channels.
Detailed information on the evolution of these de-excitation channels with
excitation energy has also been obtained. The comparison of the data with
predictions of several de-excitation models coupled to the INCL4 intra-nuclear
cascade model shows that only GEMINI can reasonably account for the bulk of
collected results, indicating that in a light system with no compression and
little angular momentum, multifragmentation might not be necessary to explain
the data.Comment: 4 pages, 5 figures, revised version accepted in Phys. Rev. Let
Extremity ring dosimetry intercomparison in reference and workplace fields
An intercomparison of ring dosemeters has been organised with the aim of assessing the technical capabilities of available extremity dosemeters and focusing on their performance at clinical workplaces with potentially high extremity doses. Twenty-four services from 16 countries participated in the intercomparison. The dosemeters were exposed to reference photon (137Cs) and beta (147Pm, 85Kr and 90Sr/90Y) fields together with fields representing realistic exposure situations in interventional radiology (direct and scattered radiation) and nuclear medicine (99 mTc and 18F). It has been found that most dosemeters provided satisfactory measurements of Hp(0.07) for photon radiation, both in reference and realistic fields. However, only four dosemeters fulfilled the established requirements for all radiation qualities. The main difficulties were found for the measurement of low-energy beta radiation. Finally, the results also showed a general under-response of detectors to 18F, which was attributed to the difficulties of the dosimetric systems to measure the positron contribution to the dos
Birth after TESEâICSI in a man with hypogonadotropic hypogonadism and congenital adrenal hypoplasia linked to a DAX-1 (NR0B1) mutation
DAX1/NR0B1 mutations are responsible for X-linked congenital adrenal hypoplasia (AHC) associated with hypogonadotropic hypogonadism (HH). Few data are available concerning testicular function and fertility in men with DAX1 mutations. Azoospermia as well as failure of gonadotrophin treatment have been reported. We induced spermatogenesis in a patient who has a DAX1 mutation (c.1210C>T), leading to a stop codon in position 404 (p.Gln404X). His endocrine testing revealed a low testosterone level at 1.2 nmol/l (N: 12â40) with low FSH and LH levels at 2.1 IU/l (N: 1â5 IU/l) and 0.1 IU/l (N: 1â4 IU/l), respectively. Baseline semen analysis revealed azoospermia. Menotropin (MenopurÂź:150 IU, three times weekly) and human chorionic gonadotrophin (1500 IU, twice weekly) were used. After 20 months of treatment, as azoospermia persisted, bilateral multiple site testicular biopsies were performed. Histology revealed severe hypospermatogenesis. Rare spermatozoa were extracted from the right posterior fragment and ICSI was performed. Four embryos were obtained and, after a frozenâthawed single-embryo transfer, the patient's wife became pregnant and gave birth to a healthy boy. We report the first case of paternity after TESEâICSI in a patient with DAX1 mutation, giving potential hope to these patients to father non-affected children. Furthermore, this case illustrates the fact that patients with X-linked AHC have a primary testicular defect in addition to HH
Active personal dosemeters in interventional radiology: tests in laboratory conditions and in hospitals
The work package 3 of the ORAMED project, Collaborative Project (2008-11) supported by the European Commission within its seventh Framework Programme, is focused on the optimisation of the use of active personal dosemeters (APDs) in interventional radiology and cardiology (IR/IC). Indeed, a lack of appropriate APD devices is identified for these specific fields. Few devices can detect low-energy X rays (20-100 keV), and none of them are specifically designed for working in pulsed radiation fields. The work presented in this paper consists in studying the behaviour of some selected APDs deemed suitable for application in IR/IC. For this purpose, measurements under laboratory conditions, both with continuous and pulsed X-ray beams, and tests in real conditions on site in different European hospitals were performed. This study highlights the limitations of APDs for this application and the need of improving the APD technology so as to fulfil all needs in the IR/IC fiel
4He decay of excited states in 14C
A study of the 7Li(9Be,4He 10Be)2H reaction at E{beam}=70 MeV has been
performed using resonant particle spectroscopy techniques and provides the
first measurements of alpha-decaying states in 14C. Excited states are observed
at 14.7, 15.5, 16.4, 18.5, 19.8, 20.6, 21.4, 22.4 and 24.0 MeV. The
experimental technique was able to resolve decays to the various particle bound
states in 10Be, and provides evidence for the preferential decay of the high
energy excited states into states in 10Be at ~6 MeV. The decay processes are
used to indicate the possible cluster structure of the 14C excited states.Comment: accepted for publication in PR
- âŠ