Redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021

El presente trabajo de investigación denominado Redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021. Se desarrolló con el objetivo principal de determinar la relación de las redes sociales y gestión de ventas en Valquiria Corporación S.A.C., Callao, 2021. La metodología utilizada fue de tipo aplicada con un nivel correlacional, enfoque cuantitativo, diseño no experimental de corte transversal. Asimismo, la población y muestra estuvo conformada por 42 colaboradores de la empresa Valquiria Corporación S.A.C, La técnica de recolección de datos fue la encuesta por medio del cuestionario compuesto de 20 preguntas provenientes de la descomposición de las variables de estudio y debidamente validadas por medio de juicio de expertos y fiabilidad de Alfa de Cronbach. Del mismo modo, para un mayor entendimiento y enriquecer la investigación se recurrió a teorías como la teoría de las redes sociales, el uso de la teoría de redes sociales en la representación y análisis de textos, la teoría de redes sociales y las políticas públicas creada por Gonzalez, teoría de demanda, Teoría AIDA y Teoría de la Cantidad Descontada. Los resultados obtenidos lograron demostrar una correlación positiva considerable entre las redes sociales y gestión de ventas en Valquiria Corporación S.A.C., demostrada por una correlación de Pearson positiva moderada (0,666), representativa para la población (p-valor de 0,000)

Subcutaneous tissue reaction to castor oil bean and calcium hydroxide in rats

Castor oil bean cement (COB) is a new material that has been used as an endodontic sealer, and is a candidate material for direct pulp capping. OBJECTIVE: The purpose of this study was to evaluate the biocompatibility of a new formulation of COB compared to calcium hydroxide cement (CH) and a control group without any material, in the subcutaneous tissue of rats. MATERIAL AND METHODS: The materials were prepared, packed into polyethylene tubes, and implanted in the rat dorsal subcutaneous tissue. Animals were sacrificed at the 7th and 50th days after implantation. A quantitative analysis of inflammatory cells was performed and data were subjected to ANOVA and Tukey's tests at 5% significance level. RESULTS: Comparing the mean number of inflammatory cells between the two experimental groups (COB and CH) and the control group, statistically significant difference (p=0.0001) was observed at 7 and 50 days. There were no significant differences (p=0.111) between tissue reaction to CH (382 inflammatory cells) and COB (330 inflammatory cells) after 7 days. After 50 days, significantly more inflammatory cells (p=0.02) were observed in the CH group (404 inflammatory cells) than in the COB group (177 inflammatory cells). CONCLUSIONS: These results demonstrate that the COB cement induces less inflammatory response within long periods

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Improper assessment of evidence by the Commercial Court and the criteria of Cassation No. 00285-2019-0-5001-SU-CI-01

El presente trabajo de suficiencia profesional consiste en analizar la indebida valoración probatoria por la Sala Comercial y el criterio de la Casación N° 00285-2019-0-5001-SU-CI-01, lo cual se encuentra vinculado con los límites de la intervención judicial en demandas de anulación de laudo arbitral. El recurso de casación fue interpuesto por el Ministerio de la Producción contra la Resolución N° 09 del 24 de mayo de 2018 emitida por la Primera Sala Comercial Permanente de la Corte Superior de Lima, la cual declaró fundada la demanda de anulación de laudo de derecho emitido en mayoría el 15 de noviembre de 2017 en los seguidos por la empresa Certificaciones del Perú S.A. quien invocó como causales de anulación las contenidas en los literales b) y d) del inciso 1 del artículo 63° del Decreto Legislativo 1071. El presente trabajo gira en torno a desarrollar algunos conceptos vinculados con la Casación seleccionada, los cuales son el derecho constitucional a la debida motivación, la aplicación de penalidades y la mala fe, las normas de orden público y de obligatorio cumplimiento, los alcances de la intervención judicial en las demandas de anulación de laudo. De igual forma, se realiza un análisis crítico de los pronunciamientos de la Sala Comercial y de la Corte Suprema concluyendo con el problema identificado y una propuesta de solución innovadora cuya aplicación podría erradicar dicho problema.The present work of professional sufficiency consists of analyzing the improper assessment of evidence by the Commercial Court and the criteria of Cassation No. 00285-2019-0-5001-SU-CI-01, which is linked to the limits of the intervention judicial in demands for annulment of arbitration award. The appeal was filed by the Ministry of Production against Resolution No. 09 of May 24, 2018 issued by the First Permanent Commercial Chamber of the Superior Court of Lima, which declared the claim for annulment of the legal award founded issued in majority on November 15, 2017 in those followed by the company Certificacións del Perú S.A. who invoked as grounds for annulment those contained in literals b) and d) of paragraph 1 of article 63° of Legislative Decree 1071. The present work revolves around developing some concepts linked to the selected Cassation, which are the constitutional right to due motivation, the application of penalties and bad faith, the rules of public order and mandatory compliance, the scope of the judicial intervention in claims for annulment of awards. Likewise, a critical analysis of the pronouncements of the Commercial Chamber and the Supreme Court is carried out, concluding with the problem identified and a proposal for an innovative solution whose application could eradicate said problem.Trabajo de Suficiencia Profesiona

Education Research: Online Alzheimer education for high school and college students: A randomized controlled trial.

OBJECTIVE: Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD: High school and college students were recruited via social media (Facebook and Instagram) to join AlzU.org, an evidence-based education portal, and were randomized to 1 of 4 courses: highly interactive webinar lessons narrated by actor Seth Rogen (celebrity webinar) or a physician (doctor webinar), minimally interactive video lessons with Seth Rogen (celebrity video), or minimally interactive video lessons (control). Surveys were administered at baseline and postcourse. The primary outcome was change in knowledge of AD risk reduction assessed by pre vs post lesson quiz scores. Secondary outcomes included change in awareness of AD research, hopefulness about AD, interest in pursuing health care, willingness to volunteer, and likelihood of recommending AlzU.org. RESULT: A total of 721 participants joined. A total of 281 (38.9%) completed the course. Among college students, quiz score improvements were greater in celebrity webinar and celebrity video vs doctor webinar and control. Among high school students, no differences were found in quiz scores. In both groups, celebrity webinar, celebrity video, and doctor webinar resulted in greater improvements in awareness that nutrition and exercise may reduce AD risk vs controls. Among college students, celebrity webinar and celebrity video group participants felt more hopeful about the future of AD and more likely to recommend AlzU.org vs doctor webinar and control participants. Among college students, celebrity webinar, celebrity video, and doctor webinar participants were more willing to volunteer for AD causes and pursue health care careers vs controls. CONCLUSION: Online education involving a celebrity may be an effective strategy for educating college students about AD risk reduction strategies. Further studies are warranted in high school students

Parturition and the perinatal period: can mode of delivery impact on the future health of the neonate?

© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society Caesarean section and instrumental delivery rates are increasing in many parts of the world for a range of cultural and medical reasons, with limited consideration as to how ‘mode of delivery’ may impact on childhood and long-term health. However, babies born particularly by pre-labour caesarean section appear to have a subtly different physiology from those born by normal vaginal delivery, with both acute and chronic complications such as respiratory and cardio-metabolic morbidities being apparent. It has been hypothesized that inherent mechanisms within the process of labour and vaginal delivery, far from being a passive mechanical process by which the fetus and placenta are expelled from the birth canal, may trigger certain protective developmental processes permissive for normal immunological and physiological development of the fetus postnatally. Traditionally the primary candidate mechanism has been the hormonal surges or stress response associated with labour and vaginal delivery, but there is increasing awareness that transfer of the maternal microbiome to the infant during parturition. Transgenerational transmission of disease traits through epigenetics are also likely to be important. Interventions such as probiotics, neonatal gut seeding and different approaches to clinical care have potential to influence parturition physiology and improve outcomes for infants. (Figure presented.)