Zuber-Jarrell House

Prepared by the Fall 1994 Conservation of Historic Building Materials class. This Historic Structure Report contains the history of the Zuber-Jarrell House, the existing conditions of the interior, exterior, infrastructure and grounds of the home, and a master plan of recommendations for the site. The main purpose of this report is to provide a restoration and management plan (presented in Section 3.0) that responds to both the historic character of the property as well as to the intentions expressed by its owner.https://scholarworks.gsu.edu/history_heritagepreservation/1046/thumbnail.jp

Hypoxia and Prostaglandin E Receptor 4 Signalling Pathways Synergise to Promote Endometrial Adenocarcinoma Cell Proliferation and Tumour Growth

The prostaglandin endoperoxide synthase (PTGS) pathway is a potent driver of tumour development in humans by enhancing the biosynthesis and signalling of prostaglandin (PG) E2. PTGS2 expression and PGE2 biosynthesis is elevated in endometrial adenocarcinoma, however the mechanism whereby PTGS and PGE2 regulate endometrial tumour growth is unknown. Here we investigated (a) the expression profile of the PGE synthase enzymes (PTGES, PTGES-2, PTGES-3) and PGE receptors (PTGER1–4) in endometrial adenocarcinomas compared with normal endometrium and (b) the role of PTGER4 in endometrial tumorigenesis in vivo. We found elevated expression of PTGES2 and PTGER4 and suppression of PTGER1 and PTGER3 in endometrial adenocarcinomas compared with normal endometrium. Using WT Ishikawa endometrial adenocarcinoma cells and Ishikawa cells stably transfected with the full length PTGER4 cDNA (PTGER4 cells) xenografted in the dorsal flanks of nude mice, we show that PTGER4 rapidly and significantly enhances tumour growth rate. Coincident with enhanced PTGER4-mediated tumour growth we found elevated expression of PTGS2 in PTGER4 xenografts compared with WT xenografts. Furthermore we found that the augmented growth rate of the PTGER4 xenografts was not due to enhanced angiogenesis, but regulated by an increased proliferation index and hypoxia. In vitro, we found that PGE2 and hypoxia independently induce expression of PTGER4 indicating two independent pathways regulating prostanoid receptor expression. Finally we have shown that PGE2 and hypoxia synergise to promote cellular proliferation of endometrial adenocarcinoma cells

Combined impact of health behaviours and mortality in men and women:the EPIC-Norfolk prospective population study

There is overwhelming evidence that behavioural factors influence health, but their combined impact on the general population is less well documented. We aimed to quantify the potential combined impact of four health behaviours on mortality in men and women living in the general community

Contos de Camp Wilde: tornando queer a pesquisa em educação ambiental Tales from Camp Wilde: queer(y)ing environmental education research

Este artigo questiona o relativo silêncio da teoria e da teorização queer sobre a pesquisa em educação ambiental. Exploramos algumas possibilidades para tornar queer a pesquisa em educação ambiental ao criar (estimulando outras/os a fazer o mesmo) narrativas de Camp Wilde, um local imaginário que nos ajuda a expor o fato de este ser um campo marcado por uma construção heteronormativa. Essas narrativas propõem métodos alternativos de representação e (re)produção do sujeito e do objeto de nossas indagações e nossas identidades como pesquisadoras/es. As/os colaboradoras/es utilizam-se de diferentes recursos teóricos como história da arte, desconstrução, ecofeminismo, crítica literária, estudos culturais populares e pós-estruturalismo feminista a fim de desenvolver uma nova orientação para a pesquisa em Educação Ambiental, a qual esperamos que jamais seja categorizada como um 'novo gênero'.<br>This paper questions the relative silence of queer theory and theorizing in environmental education research. We explore some possibilities for queering environmental education research by fabricating (and inviting colleagues to fabricate) stories of Camp Wilde, a fictional location that helps usto expose the facticity of the field's heteronormative constructedness. These stories suggest alternative ways of (re)presenting and (re)producing both the subjects/objects of our inquiries and our identities as researchers. The contributors draw on a variety of theoretical resources from art history, deconstruction, ecofeminism, literary criticism, popular cultural studies, and feminist poststructuralism to perform an orientation to environmental education research that we hope will never be arrested by its categorization as a "new genre.