AKARI Far-Infrared Source Counts in the Lockman Hole

We report initial results of far-infrared observations of the Lockman hole with Far-Infrared Surveyor (FIS) onboard the AKARI infrared satellite. On the basis of slow scan observations of a 0.6 deg x 1.2 deg contiguous area, we obtained source number counts at 65, 90 and 140 um down to 77, 26 and 194 mJy (3 sigma), respectively. The counts at 65 and 140 um show good agreement with the Spitzer results. However, our 90 um counts are clearly lower than the predicted counts by recent evolutionary models that fit the Spitzer counts in all the MIPS bands. Our 90 um counts above 26 mJy account for about 7% of the cosmic background. These results provide strong constraints on the evolutionary scenario and suggest that the current models may require modifications.Comment: 25 pages, 8 figures, Publications of the Astronomical Society of Japan, in pres

Calibration of the AKARI Far-Infrared Imaging Fourier Transform Spectrometer

The Far-Infrared Surveyor (FIS) onboard the AKARI satellite has a spectroscopic capability provided by a Fourier transform spectrometer (FIS-FTS). FIS-FTS is the first space-borne imaging FTS dedicated to far-infrared astronomical observations. We describe the calibration process of the FIS-FTS and discuss its accuracy and reliability. The calibration is based on the observational data of bright astronomical sources as well as two instrumental sources. We have compared the FIS-FTS spectra with the spectra obtained from the Long Wavelength Spectrometer (LWS) of the Infrared Space Observatory (ISO) having a similar spectral coverage. The present calibration method accurately reproduces the spectra of several solar system objects having a reliable spectral model. Under this condition the relative uncertainty of the calibration of the continuum is estimated to be $\pm$ 15% for SW, $\pm$ 10% for 70-85 cm^(-1) of LW, and $\pm$ 20% for 60-70 cm^(-1) of LW; and the absolute uncertainty is estimated to be +35/-55% for SW, +35/-55% for 70-85 cm^(-1) of LW, and +40/-60% for 60-70 cm^(-1) of LW. These values are confirmed by comparison with theoretical models and previous observations by the ISO/LWS.Comment: 22 pages, 10 figure

Phenotypic landscape of systemic lupus erythematosus: An analysis of the Kyoto Lupus Cohort

Objectives: The present study aimed to clarify comprehensive relationships among the clinical variables of systemic lupus erythematosus (SLE). Methods: We retrospectively surveyed 32 clinical variables in 581 patients and conducted comprehensive association studies among SLE clinical phenotypes. A univariate analysis of all possible combinations was performed, and the results of phenotypic correlations were reduced into two dimensions. We also created a regression formula using L1 regularisation (LASSO) to calculate the probability of exhibiting each phenotype. Results: The univariate analysis identified 26 correlations, including multiple phenotypes with low complement. Some unpredicted correlations were identified, including fever and the anti-Sm antibody (odds ratio; OR = 2.3, p = 1.6 × 10⁻⁵) or thrombocytopenia and psychosis (OR = 3.7, p = 3.2 × 10⁻⁵). The multivariate analysis accurately estimated the probability of exhibiting each phenotype (area under the curve > 0.7) in 10 out of 20 phenotypes. Conclusions: The present results show the phenotypic architecture of SLE and represent a model for estimating the probability of exhibiting each phenotype. They also offer insights into the pathology of SLE and estimating the probability of the onset of new phenotypes in clinical practice

Calibration and Performance of the AKARI Far-Infrared Surveyor (FIS) -- Slow-Scan Observation Mode for Point Sources

We present the characterization and calibration of the Slow-Scan observation mode of the Far-Infrared Surveyor (FIS) onboard the AKARI satellite. The FIS, one of the two focal-plane instruments on AKARI, has four photometric bands between 50--180 um with two types of Ge:Ga array detectors. In addition to the All-Sky Survey, FIS has also taken detailed far-infrared images of selected targets by using the Slow-Scan mode. The sensitivity of the Slow-Scan mode is one to two orders of magnitude better than that of the All-Sky Survey, because the exposure time on a targeted source is much longer. The point spread functions (PSFs) were obtained by observing several bright point-like objects such as asteroids, stars, and galaxies. The derived full widths at the half maximum (FWHMs) are ~30'' for the two shorter wavelength bands and ~40'' for the two longer wavelength bands, being consistent with those expected by the optical simulation, although a certain amount of excess is seen in the tails of the PSFs. The flux calibration has been performed by the observations of well-established photometric calibration standards (asteroids and stars) in a wide range of fluxes. After establishing the method of aperture photometry, the photometric accuracy for point-sources is better than +-15% in all of the bands expect for the longest wavelength.Comment: 25 pages, 7 figures, accepted publication in PAS

Performance of the Imaging Fourier Transform Spectrometer with Photoconductive Detector Arrays: An Application for the AKARI Far-Infrared Instrument

We have developed an imaging Fourier transform spectrometer (FTS) for space-based far-infrared astronomical observations. The FTS employs a newly developed photoconductive detector arrays with a capacitive trans-impedance amplifier, which makes the FTS a completely unique instrument. The FTS was installed as a function of the far-infrared instrument (FIS: Far-Infrared Surveyor) on the Japanese astronomical satellite, AKARI, which was launched on February 21, 2006 (UT) from the Uchinoura Space Center. The FIS-FTS had been operated for more than one year before liquid helium ran out on August 26, 2007. The FIS-FTS was operated nearly six hundreds times, which corresponds to more than one hundred hours of astronomical observations and almost the same amount of time for calibrations. As expected from laboratory measurements, the FIS-FTS performed well and has produced a large set of astronomical data for valuable objects. Meanwhile, it becomes clear that the detector transient effect is a considerable factor for FTSs with photoconductive detectors. In this paper, the instrumentation of the FIS-FTS and interesting phenomena related to FTS using photoconductive detectors are described, and future applications of this kind of FTS system are discussed.Comment: 10 pages, 6 figures, 2 tables, accepted for publication in PASJ AKARI special issu

ホスピス トクシマ ニオケル マッキ ガン カンジャ ノ ボウシュヨウセイ シンケイ ショウコウグン ノ ハッショウ ヒンド ト ソノ リンショウテキ イギ

Neurological complications in advanced cancer occur frequently and therefore an adequate neurological assessment must always be part of patient evaluation in hospice palliative care. Paraneoplastic neurological syndromes are rare, probably affecting less than 1 per cent of patients with cancer, even if the most commonly associated neoplasms, such as small-cell lung cancer and ovarian cancer are considered. Neurological complications were studied in 127 inpatients with advanced cancers. Neurological complications were seen in up to 40 per cent of the patients. The most frequent symptom was derilium, followed in order to lethargy, paraplegia, depression, dementia, hemiplegia, restlessness, aphasia, stupor, facial palsy, recurrent laryngeal nerve palsy, convulsion, and myastenia. Those symptoms were seen in patients in hepatic encephalitis（12）, metastatic brain tumor（9）, metastatic spinal cord injury（8）, depression（4）, paraneoplastic syndrome（4）, hypercalcemia（2）, senile dementia（2）, peripheral neuritis（2）, and cerebral infarction（2）. Of the four patients with paraneoplastic syndrome, one patient had both anti-Hu antibody and anti-VGCC antibody and two patients had anti-neuronal nuclear antibodies. These results indicate that paraneoplastic neurological syndromes are associated more than 1 per cent of patients with advanced cancer