1,782 research outputs found

    Improving child protection : a systematic review of training and procedural interventions

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    Aim: To synthesise published evidence regarding the effectiveness of training and procedural interventions aimed at improving the identification and management of child abuse and neglect by health professionals. Methods: Systematic review for the period 1994 to 2005 of studies that evaluated child protection training and procedural interventions. Main outcome measures were learning achievement, attitudinal change, and clinical behaviour. Results: Seven papers that examined the effectiveness of procedural interventions and 15 papers that evaluated training programmes met the inclusion criteria. Critical appraisal showed that evaluation of interventions was on the whole poor. It was found that certain procedural interventions (such as the use of checklists and structured forms) can result in improved recording of important clinical information and may also alert clinical staff to the possibility of abuse. While a variety of innovative training programmes were identified, there was an absence of rigorous evaluation of their impact. However a small number of onegroup pre- and post-studies suggest improvements in a range of attitudes necessary for successful engagement in the child protection process. Conclusion: Current evidence supports the use of procedural changes that improve the documentation of suspected child maltreatment and that enhance professional awareness. The lack of an evidence based approach to the implementation of child protection training may restrict the ability of all health professionals to fulfil their role in the child protection process. Formal evaluation of a variety of models for the delivery of this training is urgently needed with subsequent dissemination of results that highlight those found to be most effective

    Transport strategy in Scotland since devolution

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    This article critically reviews how the Scottish Executive's approach to transport has developed since devolution. Although there is much to commend, a number of concerns can be identified, including the possibility that a number of strategic infrastructure schemes appear to have been approved on political rather than on technical grounds. It is difficult to know whether the current set of transport infrastructure investment plans represents good value for public money

    The 2007 Provincial Election and Electoral System Referendum in Ontario

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    Ontario’s general election in Oct. 10, 2007, was unprecedented for several reasons. The election was held on a date fixed by legislation and not one set by the premier or his caucus, something new to Ontario and relatively new to Canadian politics. Turnout declined to 53%, the lowest ever in Ontario history. The incumbent Liberals won a second consecutive majority government, something the party had not achieved since 1937. And finally, the election featured a referendum question that asked voters in Ontario to approve reforms to the electoral system, a proposal that was overwhelmingly rejected. This article explores each of the above-stated elements as they unfolded in the election

    Applicability of DNA pools on 500 K SNP microarrays for cost-effective initial screens in genomewide association studies

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    <p>Abstract</p> <p>Background</p> <p>Genetic influences underpinning complex traits are thought to involve multiple quantitative trait loci (QTLs) of small effect size. Detection of such QTL associations requires systematic screening of large numbers of DNA markers within large sample populations. Using pooled DNA on SNP microarrays to screen for allelic frequency differences between groups such as cases and controls (called SNP Microarray and Pooling, or SNP-MaP) has been validated as an efficient solution on both 10 k and 100 k platforms. We demonstrate that this approach can be effectively applied to the truly genomewide Affymetrix GeneChip<sup>Âź </sup>Mapping 500 K Array.</p> <p>Results</p> <p>In comparisons between five independent DNA pools (<it>N </it>~200 per pool) on separate Affymetrix GeneChip<sup>Âź </sup>Mapping 500 K Array sets, we show that, for SNPs with minor allele frequencies > 0.05, the reliability of the rank order of estimated allele frequencies, assessed as the average correlation between allele frequency estimates across the DNA pools, was 0.948 (average mean difference across the five pools = 0.069). Similarly, validity of the SNP-MaP approach was demonstrated by a rank-order correlation of 0.937 (average mean difference = 0.095) between the average DNA pool allele frequency estimates and the allele frequencies of an independent (CEPH) sample of 60 unrelated individually genotyped subjects.</p> <p>Conclusion</p> <p>We conclude that SNP-MaP can be extended for use on the Affymetrix GeneChip<sup>Âź </sup>Mapping 500 K Array, providing a cost-effective, reliable and valid initial screen of 500 K SNP microarrays in genomewide association scans.</p

    A colorectal cancer missed by colon capsule endoscopy : a case report

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    Acknowledgement: We would like to thank the patient described in this case report for agreeing to publication of their case.Peer reviewe

    Syntheses and Properties of Salts of Chromophores with Ferrocenyl Electron Donor Groups and Quaternary Nitrogen Acceptors

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    A series of five new dipolar cations has been synthesized with ferrocenyl (Fc) electron donor groups connected to N-arylpyridinium, N-methylquinolinium, N-methylbenzothiazolium, or N-methylacridinium acceptors. Together with their known N-methylpyridinium analogue, these chromophores have been characterized as their PF_6^− salts by using various techniques including electronic absorption spectroscopy and cyclic voltammetry. Nine single-crystal X-ray structures have been determined, including two polymorphs of one salt obtained from a single crystallization experiment, and two of these are polar materials. A highly favorable degree of dipolar alignment for bulk NLO effects is observed in one case. Molecular quadratic nonlinear optical (NLO) responses have been determined by using femtosecond hyper-Rayleigh scattering (HRS) at 1300 nm and also via Stark (electroabsorption) spectroscopic studies on the intense π → π^* intraligand and d → π^* metal-to-ligand charge-transfer bands. A broad correlation between the electron acceptor strength and the HRS-derived first hyperpolarizabilities ÎČ and the static first hyperpolarizabilities ÎČ0 estimated from the Stark data is evident. This is the first time that meaningful (albeit indirectly determined) ÎČ_0 data have been reported for Fc compounds, allowing quantitative comparisons with the chromophore in the technologically important material (E)-4â€Č-(dimethylamino)-N-methyl-4-stilbazolium (DAS) tosylate. The observed ÎČ_0 values are in several cases similar to that of [DAS]PF_6, and possibly even larger in one instance

    Analytical sun synchronous low-thrust manoeuvres

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    Article describes analytical sun synchronous low-thrust manoeuvres

    An Information Theoretic perspective on perceptual structure: cross-accent vowel perception

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    Analytical tools from Information Theory were used to quantify behaviour in cross-accent vowel perception by Australian, London, New Zealand, Yorkshire and Newcastle UK listeners. Results show that Australian listeners impose expected patterns of perceptual similarity from their own accent experience on unfamiliar accents, regardless of the actual phonetic distance between accents

    Generalised Kundt waves and their physical interpretation

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    We present the complete family of space-times with a non-expanding, shear-free, twist-free, geodesic principal null congruence (Kundt waves) that are of algebraic type III and for which the cosmological constant (Λc\Lambda_c) is non-zero. The possible presence of an aligned pure radiation field is also assumed. These space-times generalise the known vacuum solutions of type N with arbitrary Λc\Lambda_c and type III with Λc=0\Lambda_c=0. It is shown that there are two, one and three distinct classes of solutions when Λc\Lambda_c is respectively zero, positive and negative. The wave surfaces are plane, spherical or hyperboloidal in Minkowski, de Sitter or anti-de Sitter backgrounds respectively, and the structure of the family of wave surfaces in the background space-time is described. The weak singularities which occur in these space-times are interpreted in terms of envelopes of the wave surfaces.Comment: 16 pages including 2 figures. To appear in Classical and Quantum Gra
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