Predicting success for new flavors with information known pre-launch: a flavored snack food case study

Success in the marketplace is the goal of every product launch. Knowing what data to collect before launching a product that could predict success would be valuable to companies. Thus, the objective of this study was to determine whether success of new line extensions for a multi-flavored snack product available internationally could be predicted from information available before launch. Staff from 15 countries completed a questionnaire for each product and included questions related to authenticity, familiarity, and capturing current trends, packaging and market place issues such as product competition and pricing. Using 63 flavors, a discriminant function correctly identified 75.8% successful products as successful and 66.7% unsuccessful products as unsuccessful. Stepwise comparison determined the variables necessary to correctly categorize the snack products: being a trendy flavor, new to the category, based off foods from restaurants or traditional foods. These variables assisted in predicting in market success for this product category

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a grave threat to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analyses for all three viruses. Subsequent functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 ORF9b, an interaction we structurally characterized using cryo-electron microscopy. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified molecular mechanisms and potential drug treatments that merit further molecular and clinical study

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

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