Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

IMG 305 - PEMBUNGKUSAN MAKANAN NOV.05.

We discuss the use of Agent-based Modelling for the development and testing of theories about emergent social phenomena in marketing and the social sciences in general. We address both theoretical aspects about the types of phenomena that are suitably addressed with this approach and practical guidelines to help plan and structure the development of a theory about the causes of such a phenomenon in conjunction with a matching ABM. We argue that research about complex social phenomena is still largely fundamental research and therefore an iterative and cyclical development process of both theory and model is to be expected. To better anticipate and manage this process, we provide theoretical and practical guidelines. These may help to identify and structure the domain of candidate explanations for a social phenomenon, and furthermore assist the process of model implementation and subsequent development. The main goal of this paper was to make research on complex social systems more accessible and help anticipate and structure the research process

Transverse spin asymmetry at the A4 experiment

The A4 collaboration at the MAMI accelerator has measured the transverse spin asymmetry in the cross section of elastic scattering of transversely polarized electrons off unpolarized protons. An azimuthal dependence of the asymmetry has been observed, the amplitudes have been determined as A$\perp$(Q2=0.106 (GeV/c)2 $)=({-8.59}~\pm~{0.89}_{stat}\pm~{0.75}_{syst})~\cdot~10^{-6}$ and A$\perp$(Q2=0.230 (GeV/c)2 $)=({-8.52}~\pm~{2.31}_{stat}\pm~{0.87}_{syst})~\cdot~10^{-6}$ . A$\perp$ arises from the imaginary part of the 2γ-exchange amplitude. Our experimentally determined values of A$\perp$ show that in the intermediate hadronic state not only the ground state of the proton, but also excited states contribute to the asymmetry.PACS: 13.40.Gp Electromagnetic form factors – 11.30.Er Charge conjugation, parity, time reversal, and other discrete – 13.40.-f Electromagnetic processes and properties – 14.20.Dh Properties of protons and neutrons The Author, for the A4-collaboration. This paper comprises part of the author’s PhD thesis

Extended fire tests on tinplate cans

SIGLELD:1769.7F(AERE-M--1664)(microfiche) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

An indexed list, with commentary, of experimental work connected with transport containers for radioactive material performed at Harwell 1960-1971

Incl. appendixAvailable from British Library Lending Division - LD:9091.9F(AERE-R--6797) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo