Mechanical Performance of Simple Supported Concrete Beam-Cable Composite Element with External Prestress

A new reinforcement technology of external prestress based on stretch tilted belly poles has been presented. Taking simply supported beam, which is reinforced by three titled belly poles, as a research object to establish a model of reinforced simply supported beam. Relationship expressions about deflection and internal force increment of external cable or about load and deflection have been deduced. Finite element model is established by ABAQUS. The influence of structure performance of reinforced simply supported beam with cable section, cable sag and initial internal force value was investigated. Three tests are carried out to testify the results of theoretical analysis and numerical simulation. The results show that the redistributions of internal force and sectional stress have occurred, and the stiffness, crack load, ultimate load, and structure ductility are all improved with the increase of three design parameters. For example, the crack load, ultimate load, and structure ductility have increased, respectively, by 24%~40%, 15%~42%, and 14%~40%. High initial internal force, small section, and big cable sag should be avoided, because the probability of brittle failure of structure will increase. The analytical result shows that the reliability of internal increment expression of external cable and carrying capacity expression can be used in the engineering practice

Leveraging BEV Representation for 360-degree Visual Place Recognition

This paper investigates the advantages of using Bird's Eye View (BEV) representation in 360-degree visual place recognition (VPR). We propose a novel network architecture that utilizes the BEV representation in feature extraction, feature aggregation, and vision-LiDAR fusion, which bridges visual cues and spatial awareness. Our method extracts image features using standard convolutional networks and combines the features according to pre-defined 3D grid spatial points. To alleviate the mechanical and time misalignments between cameras, we further introduce deformable attention to learn the compensation. Upon the BEV feature representation, we then employ the polar transform and the Discrete Fourier transform for aggregation, which is shown to be rotation-invariant. In addition, the image and point cloud cues can be easily stated in the same coordinates, which benefits sensor fusion for place recognition. The proposed BEV-based method is evaluated in ablation and comparative studies on two datasets, including on-the-road and off-the-road scenarios. The experimental results verify the hypothesis that BEV can benefit VPR by its superior performance compared to baseline methods. To the best of our knowledge, this is the first trial of employing BEV representation in this task

Enzymatic hydrolysate from velvet antler suppresses adipogenesis in 3T3-L1 cells and attenuates obesity in high-fat diet-fed mice

The purpose of the current study was to investigate the potential anti-obesity activity of an enzymatic hydrolysate of velvet antler in inhibiting adipogenesis in 3T3-L1 cells and in high-fat diet (HFD)-fed obese mice. The enzy- matic hydrolysate was prepared using the commercial food grade protease, Protamex. The velvet antler Protamex hydrolysate (VAPH) indicated profound inhibitory effects on adipogenesis dose-dependently by decreasing the accumulation of triglycerides and down-regulating expression levels of adipogenesis-related proteins C/EBPα, SREBP-1, and PPARγ. In a mouse model of HFD-induced obesity, oral administration of VAPH (100 and 300 mg/kg for 13 weeks) significantly reduced the body weight gain that had resulted from the HFD. VAPH treat- ment also lowered the serum glucose and triglyceride levels, while increasing the HDL-C level. Furthermore, the treatment greatly reduced hepatic lipid droplet accumulation as well as the size of adipocytes. Current findings H has profound anti-obesity effects and could be an effective candidate for preventing obesity and obesity-related chronic diseases

Photodegradation of Methylene Blue by TiO 2

Fe3O4-bentonite nanoparticles have been prepared by a coprecipitation technique under a nitrogen atmosphere. An aqueous suspension of bentonite was first modified with FeCl2 and FeCl3. TiO2 was then loaded onto the surface of the Fe3O4-bentonite by a sol-gel method. After sufficient drying, the colloidal solution was placed in a muffle furnace at 773 K to obtain the TiO2-Fe3O4-bentonite composite. The material has been characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis, and vibrating sample magnetometry (VSM). Morphological observation showed that Fe3O4 and TiO2 nanoparticles had been adsorbed on the surface of bentonite nanoneedles. The material was then applied for the photodegradation of the azo dye methylene blue (MB). It was found that the removal efficiency of MB exceeded 90% under UV illumination, and that only a 20% mass loss was incurred after six cycles. The composite material thus showed good photocatalytic performance and recycling properties

Anti-inflammatory effects of enzymatic hydrolysates of velvet antler in RAW 264.7 cells in vitro and zebrafish model

Enzymatic hydrolysis has been successfully used for the extraction of numerous biologically active components from a wide variety of natural sources. In the present study, velvet antler was subjected to the extraction process using Alcalase protease. We analyzed bioactive components, such as uronic acid, sulfated-glycosaminoglycans (sulfated-GAGs), and sialic acid, present in the velvet antler Alcalase hydrolysate (VAAH) and assessed their anti-inflammatory effects in zebrafish as well as in vitro using cell lines. VAAH mainly contained uronic acid (78.22 mg/g) and sulfated-GAGs (50.47 mg/g), while the amount of sialic acid was negligible (5.55 mg/g). VAAH inhibited the production of nitric oxide (NO) by lipopolysaccharide (LPS)-induced cells in a dosedependent manner and the inhibitory effect of VAAH on NO production was higher than that of hot water extracts. VAAH treatment also reduced the expression of inflammatory mediators such as nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Furthermore, we evaluated anti-inflammatory effects of VAAH using LPS-stimulated zebrafish. Treatment with LPS significantly increased cell death, NO, and reactive oxygen species (ROS) levels in zebrafish. Notably, VAAH significantly inhibited the extent of LPS-stimulated cell death and generation of NO and ROS in zebrafish. These results suggest that VAAH alleviated inflammation and cell death by inhibiting the generation of ROS induced by LPS treatment. Thus, VAAH could be used as a potential natural remedy with a trong anti-inflammatory effect. Taken together, we believe that based on our present results, enzymatic hydrolysis of velvet antler may be an effective process to make antler products acceptable as elements of health foods and nutraceutical components with increased biological activity

Exploring the Immunotoxicity of Carbon Nanotubes

Mass production of carbon nanotubes (CNTs) and their applications in nanomedicine lead to the increased exposure risk of nanomaterials to human beings. Although reports on toxicity of nanomaterials are rapidly growing, there is still a lack of knowledge on the potential toxicity of such materials to immune systems. This article reviews some existing studies assessing carbon nanotubes’ toxicity to immune system and provides the potential mechanistic explanation