Product market competition and corporate governance disclosure: evidence from the UK

In this study we measure multiple dimensions of product market competition and examine their impacts on corporate governance disclosure, based on a sample of UK public firms over the period 2001 to 2009. We use factor analysis to explore the different dimensions of product market competition; and regression models to analyse the association between multiple dimensions of product market competition and corporate governance disclosure. We find that firms in less competitive industries have significantly more corporate governance disclosure. Furthermore, we detect a positive association between corporate governance disclosure and board independence, as well as audit committee independence. This suggests that firms with better corporate governance tend to disclose more information to external investors. Overall the findings support the view that managers use more corporate governance disclosure as a substitute for the external disciplinary force of product market competition

Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma

Normal adjacent tissues (NATs) of hepatocellular carcinoma (HCC) differ from healthy liver tissues and their heterogeneity may contain biological information associated with disease occurrence and clinical outcome that has yet to be fully evaluated at the proteomic level. This study provides a detailed description of the heterogeneity of NATs and the differences between NATs and healthy livers and revealed that molecular features of tumor subgroups in HCC were partially reflected in their respective NATs. Proteomic data classified HCC NATs into two subtypes (Subtypes 1 and 2), and Subtype 2 was associated with poor prognosis and high-risk recurrence. The pathway and immune features of these two subtypes were characterized. Proteomic differences between the two NAT subtypes and healthy liver tissues were further investigated using data-independent acquisition mass spectrometry, revealing the early molecular alterations associated with the progression from healthy livers to NATs. This study provides a high-quality resource for HCC researchers and clinicians and may significantly expand the knowledge of tumor NATs to eventually benefit clinical practice

m6A modifications regulate intestinal immunity and rotavirus infection

N6-methyladenosine (m6A) is an abundant mRNA modification and affects many biological processes. However, how m6A levels are regulated during physiological or pathological processes such as virus infections, and the in vivo function of m6A in the intestinal immune defense against virus infections are largely unknown. Here, we uncover a novel antiviral function of m6A modification during rotavirus (RV) infection in small bowel intestinal epithelial cells (IECs). We found that rotavirus infection induced global m6A modifications on mRNA transcripts by down-regulating the m6a eraser ALKBH5. Mice lacking the m6A writer enzymes METTL3 in IECs

Statistical analysis of the owl:sameAs network for aligning concepts in the linking open data cloud

The massively distributed publication of linked data has brought to the attention of scientific community the limitations of classic methods for achieving data integration and the opportunities of pushing the boundaries of the field by experimenting this collective enterprise that is the linking open data cloud. While reusing existing ontologies is the choice of preference, the exploitation of ontology alignments still is a required step for easing the burden of integrating heterogeneous data sets. Alignments, even between the most used vocabularies, is still poorly supported in systems nowadays whereas links between instances are the most widely used means for bridging the gap between different data sets. We provide in this paper an account of our statistical and qualitative analysis of the network of instance level equivalences in the Linking Open Data Cloud (i.e. the sameAs network) in order to automatically compute alignments at the conceptual level. Moreover, we explore the effect of ontological information when adopting classical Jaccard methods to the ontology alignment task. Automating such task will allow in fact to achieve a clearer conceptual description of the data at the cloud level, while improving the level of integration between datasets. <br/