Impaired Tactile Temporal Discrimination in Patients With Hepatic Encephalopathy

The sensory system constantly receives stimuli from the external world. To discriminate two stimuli correctly as two temporally distinct events, the temporal distance or stimulus onset asynchrony (SOA) between the two stimuli has to exceed a specific threshold. If the SOA between two stimuli is shorter than this specific threshold, the two stimuli will be perceptually fused and perceived as one single stimulus. Patients with hepatic encephalopathy (HE) are known to show manifold perceptual impairments, including slowed visual temporal discrimination abilities as measured by the critical flicker frequency (CFF). Here, we hypothesized that HE patients are also impaired in their tactile temporal discrimination abilities and, thus, require a longer SOA between two tactile stimuli to perceive the stimuli as two temporally distinct events. To test this hypothesis, patients with varying grades of HE and age-matched healthy individuals performed a tactile temporal discrimination task. All participants received two tactile stimuli with varying SOA applied to their left index finger and reported how many distinct stimuli they perceived (“1” vs. “2”). HE patients needed a significantly longer SOA (138.0 ± 11.3 ms) between two tactile stimuli to perceive the stimuli as two temporally distinct events than healthy controls (78.6 ± 13.1 ms; p < 0.01). In addition, we found that the temporal discrimination ability in the tactile modality correlated positively with the temporal discrimination ability in the visual domain across all participants (i.e., negative correlation between tactile SOA and visual CFF: r = −0.37, p = 0.033). Our findings provide evidence that temporal tactile perception is substantially impaired in HE patients. In addition, the results suggest that tactile and visual discrimination abilities are affected in HE in parallel. This finding might argue for a common underlying pathophysiological mechanism. We argue that the known global slowing of neuronal oscillations in HE might represent such a common mechanism

Trajectory and orbit of the unique carbonaceous meteorite Flensburg

The C1-ungrouped carbonaceous chondrite Flensburg fell in Germany on September 12, 2019, in the daytime. We determined the atmospheric trajectory, velocity, and heliocentric orbit using one dedicated AllSky6 meteor camera and three casual video records of the bolide. It was found that the meteorite originated in the vicinity of the 5:2 resonance with Jupiter at heliocentric distance of 2.82 AU. When combined with the bolide energy reported by the U.S. Government sensors (USGS), the pre-atmospheric diameter of the meteoroid was estimated to 2 - 3 meters and the mass to 10,000 - 20,000 kg. The meteoroid fragmented heavily in the atmosphere at heights of 46 - 37 km, under dynamic pressures of 0.7 - 2 MPa. The recovery of just one meteorite suggests that only a very small part of the original mass reached the ground. The bolide velocity vector was compared with that reported by the USGS. There is good agreement in the radiant but the velocity value has been underestimated by the USGS by almost 1 km/s.Comment: Preprint accepted for publication in Meteoritics & Planetary Science after a minor revisio

Synthesis and photoinduced behavior of DPPanchored nitronyl nitroxides:a multifaceted approach

Understanding and controlling spin dynamics in organic dyes is of significant scientific and technological interest. The investigation of 2,5-dihydropyrrolo[4,3-c]pyrrolo-1,4-dione derivatives (DPPs), one of the most widely used dyes in many fields, has so far been limited to closed-shell molecules. We present a comprehensive joint experimental and computational study of DPP derivatives covalently linked to two nitronyl nitroxide radicals (DPPTh-NN2). Synthesis, single crystal X-ray diffraction study, photophysical properties, magnetic properties established using steady-state and pulse EPR, fast spin dynamics, and computational modelling using density functional theory and ab initio methods of electronic structure and spectroscopic properties of DPPTh-NN2 are presented. The single-crystal X-ray diffraction analysis of DPPTh-NN2 and computational modeling of its electronic structure suggest that effective conjugation along the backbone leads to noticeable spin-polarization transfer. Calculations using ab initio methods predict a weak exchange interaction of radical centers through a singlet ground state of DPPTh with a small singlet-triplet splitting (ΔEST) of about 25 cm-1 (∼0.07 kcal mol-1). In turn, a strong ferromagnetic exchange interaction between the triplet state of DPPTh chromophore and nitronyl nitroxides (with J ∼ 250 cm-1) was predicted.</p