How to Apply A Strategic Approach to Deliver Legacies from Hosting Mega Sport Events

In the process of bidding for and organizing mega sport events (e.g., Olympics, Paralympics, and FIFA World Cups), there are many opportunities to leave a legacy for the host communities. The more obvious legacies are new stadiums, better transport, and urban redevelopment. Less obvious legacies are increased sport participation and enhanced volunteering activity. There is little research after the events that demonstrate these legacies. This Research Report is informed by recent research that highlights the lack of strategic planning for legacies. To outline how a host community could increase their chances of delivering legacies after hosting mega sport events this paper applies a common business approach, strategic management

Terrain park injuries and risk factors in western Canadian resorts, 2008–2009 to 2017–2018: insights for risk management

Terrain parks (TP) are popular attractors to snowsport resorts for both skiers and snowboarders, however there is some concern about the risk of severe injury. TP risk management needs to balance the business case against the human cost of injury. To inform effective TP risk management strategies, it essential to understand risk factors, and injury frequency and severity. To this end, a retrospective inductive analysis of Canada West Ski Areas Association's Accident Analyzer database (2008–2009 to 2017–2018). Inclusion criteria., (i) at least 8 seasons of matching injury and participation data, (ii) minimum of 10 TP injuries p.a., (iii) activity either skiing or snowboarding, and (iv) injury location was coded as terrain park/rail. Data was excluded for ticket type N/A. Anonymised and deidentified secondary data was entered into SPSS for analysis. Between group differences were explored via χ2 analysis with Yates' Continuity Correction for 2 × 2 tables and an inductive data driven approach to explore other factors. From this data, 12,602 injuries were in TPs across 28 resorts. 11,940 (94.7%) met the inclusion criteria (14.2% female; 86.5% <25 years; 73.0% snowboarders. 50.8% were male snowboarders <25 years). Higher levels of helmet use were not correlated with a decline in reported head injuries. Day-ticket holders were more likely to be injured on their first two uses of a run than season pass holders. More snowboarders injured in TPs (59.7%) went to hospital than skiers (51.0%). Thus, participants injured in TP are typically younger, male, and snowboarders with either a Season Pass or day ticket, thus potentially a distinct target group for injury mitigation and prevention strategies and communications. The application of other frameworks such as the hierarchy of control and socioecological framework reflects the complex multifactorial systems in which snowsports occur and from which more targeted risk management strategies may emerge to mitigate injury risk while maintaining TP appeal

How is the Australian tourism and hospitality curriculum and assessment quality framework perceived elsewhere? A Taiwanese Case Study

External evaluations of curriculum and assessment design have received increasing attention in higher education. However, cross- border evaluations of programs have not yet caught up with the more significant push toward the internationalisation of global partnerships. Addressing this knowledge gap, the motivation of this study is to explore how the Australian tourism and hospitality curriculum and assessment framework is perceived in Taiwan. However, few institutions in Taiwan have embarked on this due to two main factors – lack of nationwide compliance and the perceived high-power distance that exists between academic staff of various ranks (e.g. professor vs. assistant professor). These out-comes contribute to a more nuanced understanding of the con-textual differences that need to be addressed before adopting cross-national forms of external referencing involving curriculum and assessments. Insights from three focus groups and seven in- depth interviews with Taiwanese academics offer some strategies to introduce effective external evaluation outcomes

Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa.

Marburg virus (MARV) causes sporadic outbreaks of severe Marburg virus disease (MVD). Most MVD outbreaks originated in East Africa and field studies in East Africa, South Africa, Zambia, and Gabon identified the Egyptian rousette bat (ERB; Rousettus aegyptiacus) as a natural reservoir. However, the largest recorded MVD outbreak with the highest case-fatality ratio happened in 2005 in Angola, where direct spillover from bats was not  shown. Here, collaborative studies by the Centers for Disease Control and Prevention, Njala University, University of California, Davis USAID-PREDICT, and the University of Makeni identify MARV circulating in ERBs in Sierra Leone. PCR, antibody and virus isolation data from 1755 bats of 42 species shows active MARV infection in approximately 2.5% of ERBs. Phylogenetic analysis identifies MARVs that are similar to the Angola strain. These results provide evidence of MARV circulation in West Africa and demonstrate the value of pathogen surveillance to identify previously undetected threats

Digitising diabetes education for a safer Ramadan:Design, delivery, and evaluation of massive open online courses in Ramadan-focused diabetes education

Aims: Ramadan-focused diabetes education is critical to facilitate safer Ramadan fasting amongst Muslim people living with diabetes. We present the design, delivery, and evaluation of two parallel massive open online courses (MOOCs) in Ramadan-focused diabetes education for people with diabetes and HCPs. Methods: Two Ramadan-focused diabetes education MOOCs were developed and delivered for Ramadan 2023: one for HCPs in English, and another for people with diabetes in English, Arabic and Malay. A user-centred iterative design process was adopted, informed by user feedback from a 2022 pilot MOOC. Evaluation comprised a mixed-methods evaluation of pre- and post-course user surveys. Results: The platform was utilised by people with diabetes and their family, friends and healthcare professionals. Overall, a total of 1531 users registered for the platform from 50 countries, 809 started a course with a 48% subsequent completion rate among course starters. Qualitative analysis showed users found the course a user-friendly and authoritative information source. In the HCP MOOC, users reported improved post-MOOC Ramadan awareness, associated diabetes knowledge and ability to assess and advise patients in relation to their diabetes during Ramadan (p&lt;0.01). Conclusions: We demonstrate the potential of MOOCs to deliver culturally tailored, high-quality, scalable, multilingual Ramadan-focused diabetes education to HCPs and people with diabetes.</p

MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma

<p>ABSTRACT</p> <p>Background</p> <p>Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer mortalities. With regards to the role of miRNAs in neuroblastoma, miR-34a, mapping to a chromosome 1p36 region that is commonly deleted, has been found to act as a tumor suppressor through targeting of numerous genes associated with cell proliferation and apoptosis.</p> <p>Methods</p> <p>A synthetic miR-34a (or negative control) precursor molecule was transfected into NB1691^lucand SK-N-AS^lucneuroblastoma cells. Quantitative PCR was used to verify increased miR-34a levels in NB1691^lucand SK-N-AS^luccell lines prior to <it>in vitro </it>and <it>in vivo </it>analysis. <it>In vitro </it>analysis of the effects of miR-34a over expression on cell growth, cell cycle and phosphoprotein activation in signal transduction pathways was performed. Neuroblastoma cells over expressing miR-34a were injected retroperitoneally into immunocompromised CB17-SCID mice and tumor burden was assessed over a 21 day period by measuring bioluminescence (photons/sec/cm²).</p> <p>Results</p> <p>Over expression of miR-34a in both NB1691^lucand SK-N-AS^lucneuroblastoma cell lines led to a significant decrease in cell number relative to premiR-negative control treated cells over a 72 hour period. Flow cytometry results indicated that miR-34a induced cell cycle arrest and subsequent apoptosis activation. Phosphoprotein analysis highlighted key elements involved in signal transduction, whose activation was dysregulated as a result of miR-34a introduction into cells. As a potential mechanism of miR-34a action on phosphoprotein levels, we demonstrate that miR-34a over-expression results in a significant reduction of <it>MAP3K9 </it>mRNA and protein levels. Although <it>MAP3K9 </it>is a predicted target of miR-34a, direct targeting could not be validated with luciferase reporter assays. Despite this fact, any functional effects of reduced MAP3K9 expression as a result of miR-34a would be expected to be similar regardless of the mechanism involved. Most notably, <it>in vivo </it>studies showed that tumor growth was significantly repressed after exogenous miR-34a administration in retroperitoneal neuroblastoma tumors.</p> <p>Conclusion</p> <p>We demonstrate for the first time that miR-34a significantly reduces tumor growth in an <it>in vivo </it>orthotopic murine model of neuroblastoma and identified novel effects that miR-34a has on phospho-activation of key proteins involved with apoptosis.</p

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy