38 research outputs found

    Predictive ability of both the healthy aging index and the frailty index for all-cause mortality

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    Aim: We aimed to develop and assess a modified healthy aging index (HAI) among Chileans aged 60 years and older and compare its predictive ability for all-cause mortality risk with the frailty index (FI). Methods: This prospective study analyzed data from the Chilean National Health Survey (CNHS) conducted in 2009–2010. We included 847 adults with complete data to construct the HAI and FI. The HAI comprised five indicators (lung function, systolic blood pressure, fasting glucose, cognitive status, and glomerular filtration rate), while the FI assessed frailty using a 36-item scale. HAI scores were calculated by summing the indicator scores, ranging from 0 to 10, with higher scores indicating poorer health. Receiver operating curves (ROC) and area under the curve (AUC) were used to assess predictive validity. Associations with all-cause mortality were assessed using Cox proportional hazard models adjusted by confounders. Results: The mean HAI score was 4.06, while the FI score was 0.24. The AUC for mortality was higher for the HAI than the FI (0.640, 95% confidence interval (CI) 0.601 to 0.679 vs. 0.586, 95% CI 0.545 to 0.627). After adjusting for confounders, the FI showed a higher mortality risk compared to the HAI (2.63, 95% CI 1.76 to 3.51 vs. 1.16, 95% CI 1.08 to 1.26). Conclusion: The FI and HAI were valid predictors for all-cause mortality in the Chilean population. Integrating these indices into research and clinical practice can significantly enhance our capacity to identify at-risk individuals

    El Estrés Laboral Y Su Afectación En La Empresa Y En Los Empleados De Un Contact Center De La Ciudad De Manizales

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    Número 7; pp. 6 - 15Se realizó un estudio sobre el estrés laboral, identificando y describiendo los niveles de estrés, determinando cuales son las causas de los niveles de estrés laboral de los empleados, cuál es la afectación financiera en una organización del mercado del Contact Center en la ciudad de Manizales en el área de Atención al cliente con venta cruzada. Para ello se realizó un estudio de carácter cualitativo con manejo cuantitativo de los datos, para encontrar respuestas por medio de evidencias numéricas y poder explicar con más detalle la presencia del evento, para esto se utilizó como instrumental de apoyo la escala de Estrés laboral de la OIT-OMS. Entre los resultados se encontró que el estrés laboral está por debajo del límite del rango de estrés intermedio (81,09 / 90,02) y que la empresa por Absentismo y Rotación, ha perdido aproximadamente $43`995.586 según los cálculos aproximados del dinero.Universidad Libre Seccional Pereir

    Implementación de TVIP en máquinas virtuales GNS3

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    Con el presente trabajo se logra adecuar los conceptos aprendidos que se llevaron a cabo a través de las fases desarrolladas en el grado, con lo cual se busca que se relacione con un escenario convergente de IP; identificando las redes de nueva generación y aquellos servicios que se soportan en este tipo de escenarios de red, mediante la investigación de conceptos actuales, que serán la base dentro de una arquitectura de red, reconociendo los protocolos y funciones de la capa de red, mediante el uso de principios de direccionamiento IP, dentro de los estándares y en este reconocer las capas, protocolos, funciones y ventajas de una arquitectura NGN utilizada en la interconexión de redes.With this work manage to adapt the concepts learned that were carried out through the phases developed in the grade, with which it is sought that it relates to a convergent scenario of IP; identifying the new generation networks and those services that are supported on this type of network scenarios. The layers and functions of a network model, through the investigation of current concepts, which will be the basis within a network architecture, recognizing the Protocols and functions of the network layer, using addressing principles IP, within the standards and in this way recognize the layers, protocols, functions, and advantages of an NGN Architecture used in the interconnection of networks

    Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

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    Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

    Robust estimation of bacterial cell count from optical density

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    Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

    Estudio teórico sobre vejez y envejecimiento

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    Identificar las principales teorías que han aportado al estudio de la vejez y el envejecimiento durante los últimos 10 años que permitan la elaboración de un marco conceptual pertinente para la disciplina de trabajo socialEl presente trabajo de investigación precisa identificar las principales teorías que han aportado al estudio de la vejez y el envejecimiento durante los últimos 10 años que permitan la elaboración de un marco conceptual pertinente para la disciplina de trabajo social. El estudio se fundamenta en aspectos teóricos como: Calidad de vida, teoría del desarrollo humano y envejecimiento, teoría a escala humana y vejez, y teorías sociológicas y vejez, con líneas de investigación integradas como la psicología, medicina, enfermería, trabajo social desde una perspectiva social. Para lograr el objetivo se emplea una investigación documental desde el enfoque cualitativo, permitiendo la recolección de información sobre el envejecimiento y la vejez. Las teorías que han aportado al estudio de la vejez y el envejecimiento, están influenciadas por el por el bienestar físico, social, emocional, espiritual, intelectual y ocupacional que le permite satisfacer necesidades a los adultos mayores. En conclusión, como trabajadores sociales, uno de los grandes retos, es la necesidad de integrarnos de forma multidisciplinar y multisectorial, no solo para enfrentar este fenómeno del envejecimiento poblacional desde el punto de vista social, sino también, en el orden individual, para lograr que la población envejezca con calidad.The present research work needs to identify the main theories that have contributed to the study of old age and aging during the last 10 years that allow the elaboration of a pertinent conceptual framework for the discipline of social work. The study is based on theoretical aspects such as: Quality of life, theory of human development and aging, theory on a human scale and old age, and sociological and old age theories, with integrated lines of research such as psychology, medicine, nursing, social work from a social perspective. To achieve the objective, documentary research is used from the qualitative approach, allowing the collection of information on aging and old age. The theories that have contributed to the study of old age and aging are influenced by the physical, social, emotional, spiritual, intellectual and occupational well-being that allows the needs of older adults to be met. In conclusion, as social workers, one of the great challenges is the need to integrate in a multidisciplinary and multisectoral way, not only to face this phenomenon of population aging from the social point of view, but also, in the individual order, to achieve that the population ages with qualit

    Estudio teórico sobre vejez y envejecimiento

    No full text
    Identificar las principales teorías que han aportado al estudio de la vejez y el envejecimiento durante los últimos 10 años que permitan la elaboración de un marco conceptual pertinente para la disciplina de trabajo socialEl presente trabajo de investigación precisa identificar las principales teorías que han aportado al estudio de la vejez y el envejecimiento durante los últimos 10 años que permitan la elaboración de un marco conceptual pertinente para la disciplina de trabajo social. El estudio se fundamenta en aspectos teóricos como: Calidad de vida, teoría del desarrollo humano y envejecimiento, teoría a escala humana y vejez, y teorías sociológicas y vejez, con líneas de investigación integradas como la psicología, medicina, enfermería, trabajo social desde una perspectiva social. Para lograr el objetivo se emplea una investigación documental desde el enfoque cualitativo, permitiendo la recolección de información sobre el envejecimiento y la vejez. Las teorías que han aportado al estudio de la vejez y el envejecimiento, están influenciadas por el por el bienestar físico, social, emocional, espiritual, intelectual y ocupacional que le permite satisfacer necesidades a los adultos mayores. En conclusión, como trabajadores sociales, uno de los grandes retos, es la necesidad de integrarnos de forma multidisciplinar y multisectorial, no solo para enfrentar este fenómeno del envejecimiento poblacional desde el punto de vista social, sino también, en el orden individual, para lograr que la población envejezca con calidad.The present research work needs to identify the main theories that have contributed to the study of old age and aging during the last 10 years that allow the elaboration of a pertinent conceptual framework for the discipline of social work. The study is based on theoretical aspects such as: Quality of life, theory of human development and aging, theory on a human scale and old age, and sociological and old age theories, with integrated lines of research such as psychology, medicine, nursing, social work from a social perspective. To achieve the objective, documentary research is used from the qualitative approach, allowing the collection of information on aging and old age. The theories that have contributed to the study of old age and aging are influenced by the physical, social, emotional, spiritual, intellectual and occupational well-being that allows the needs of older adults to be met. In conclusion, as social workers, one of the great challenges is the need to integrate in a multidisciplinary and multisectoral way, not only to face this phenomenon of population aging from the social point of view, but also, in the individual order, to achieve that the population ages with qualit
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