USO DE ANESTÉSICOS EM FACECTOMIAS: UMA ANÁLISE DAS TÉCNICAS E RESULTADOS CLÍNICOS

Facectomy, also known as cataract surgery, is an ophthalmological procedure widely performed to remove the opaque lens of the eye and replace it with an artificial intraocular lens. Therefore, the analysis of different anesthetic techniques, such as local anesthesia, conscious sedation and general anesthesia, is essential to determine the most appropriate approach and optimize clinical results and the patient experience. Objective: To investigate and compare the different anesthetic methods used during facectomy surgery, analyzing their effects on the safety, effectiveness and recovery of patients. Methodology: The Cochrane, Scielo and Medline databases were used, searching for articles published between 2018 and 2024, in Portuguese or English. Final Considerations: Local anesthesia with conscious sedation is preferable due to its effectiveness, safety and rapid patient recovery. Compared to general anesthesia, local anesthesia had a lower incidence of complications and postoperative pain, in addition to being more economical. Patients undergoing this technique reported high satisfaction. Therefore, local anesthesia is recommended as a standard approach, except in specific cases that require general anesthesia, in order to optimize clinical results and the patient experience.A facectomia, também conhecida como cirurgia de catarata, é um procedimento oftalmológico amplamente realizado para remover o cristalino opaco do olho e substituí-lo por uma lente intraocular artificial. Portanto, a análise das diferentes técnicas anestésicas, como anestesia local, sedação consciente e anestesia geral, é fundamental para determinar a abordagem mais adequada e otimizar os resultados clínicos e a experiência do paciente. Objetivo: Investigar e comparar os diferentes métodos anestésicos utilizados durante a cirurgia de facectomia, analisando seus efeitos sobre a segurança, eficácia e recuperação dos pacientes. Metodologia:  Foram utilizadas as bases de dados Cochrane, Scielo e Medline, buscando artigos publicados entre os anos de 2018 e 2024, nos idiomas Português ou Inglês. Considerações Finais: A anestesia local com sedação consciente é preferível devido à sua eficácia, segurança e recuperação rápida dos pacientes. Comparada à anestesia geral, a anestesia local apresentou menor incidência de complicações e dor pós-operatória, além de ser mais econômica. Pacientes submetidos a esta técnica relataram alta satisfação. Portanto, recomenda-se a anestesia local como abordagem padrão, exceto em casos específicos que exigem anestesia geral, visando otimizar os resultados clínicos e a experiência do paciente

Manifestações Cutâneas do Lúpus Eritematoso Sistêmico: Desafios Diagnósticos e Estratégias de Manejo

Introduction: Cutaneous manifestations of systemic lupus erythematosus (SLE) represent a significant and challenging aspect of this autoimmune disease. This study aims to explore management strategies for these cutaneous manifestations, with the goal of improving understanding and treatment of this complex dermatological condition. Objective: The objective of this study is to analyze management strategies for cutaneous manifestations of SLE, highlighting diagnostic and therapeutic approaches, as well as challenges faced in clinical practice. The intention is to provide a comprehensive overview of available treatment options and identify areas in need of further investigation and development. Methodology: To achieve this objective, a systematic literature review was conducted using specific descriptors related to systemic lupus erythematosus and its cutaneous manifestations. Relevant studies were selected based on pre-defined inclusion criteria, considering their methodological quality and relevance to the topic at hand. Results: Analysis of selected studies revealed a variety of management strategies for cutaneous manifestations of SLE, including topical and systemic treatments, complementary therapies, and preventive measures. Additionally, diagnostic challenges such as overlap with other dermatological conditions, and therapeutic challenges such as the need for more effective treatment options with fewer side effects, were identified. Conclusion: Management of cutaneous manifestations of SLE requires a multidisciplinary and individualized approach, aiming to control disease activity, prevent complications, and improve patients' quality of life. Continuous research and development of new therapies are essential to advance the treatment of this challenging dermatological condition.  Introdução: As manifestações cutâneas do lúpus eritematoso sistêmico (LES) representam uma parte significativa e desafiadora dessa doença autoimune. Este estudo busca explorar as estratégias de manejo dessas manifestações cutâneas, com o objetivo de melhorar a compreensão e o tratamento dessa condição dermatológica complexa. Objetivo: O objetivo deste estudo é analisar as estratégias de manejo das manifestações cutâneas do LES, destacando abordagens diagnósticas, terapêuticas e desafios enfrentados na prática clínica. Pretende-se fornecer uma visão abrangente das opções de tratamento disponíveis e identificar áreas que necessitam de maior investigação e desenvolvimento. Metodologia Para alcançar este objetivo, foi realizada uma revisão sistemática da literatura, utilizando descritores específicos relacionados ao lúpus eritematoso sistêmico e suas manifestações cutâneas. Os estudos relevantes foram selecionados com base em critérios de inclusão definidos previamente, considerando sua qualidade metodológica e relevância para o tema em questão. Resultados: A análise dos estudos selecionados revelou uma variedade de estratégias de manejo das manifestações cutâneas do LES, incluindo tratamentos tópicos e sistêmicos, terapias complementares e medidas preventivas. Além disso, foram identificados desafios diagnósticos, como a sobreposição com outras condições dermatológicas, e terapêuticas, como a necessidade de opções de tratamento mais eficazes e com menos efeitos colaterais. Conclusão: O manejo das manifestações cutâneas do LES requer uma abordagem multidisciplinar e individualizada, visando controlar a atividade da doença, prevenir complicações e melhorar a qualidade de vida dos pacientes. A pesquisa contínua e o desenvolvimento de novas terapias são fundamentais para avançar no tratamento dessa condição dermatológica desafiadora

Expanding the phenotypic spectrum of CLCN2-related leucoencephalopathy and ataxia

Mutations in CLCN2 are a rare cause of autosomal recessive leucoencephalopathy with ataxia and specific imaging abnormalities. Very few cases have been reported to date. Here, we describe the clinical and imaging phenotype of 12 additional CLCN2 patients and expand the known phenotypic spectrum of this disorder. Informed consent was obtained for all patients. Patients underwent either whole-exome sequencing or focused/panel-based sequencing to identify variants. Twelve patients with biallelic CLCN2 variants are described. This includes three novel likely pathogenic missense variants. All patients demonstrated typical MRI changes, including hyperintensity on T2-weighted images in the posterior limbs of the internal capsules, midbrain cerebral peduncles, middle cerebellar peduncles and cerebral white matter. Clinical features included a variable combination of ataxia, headache, spasticity, seizures and other symptoms with a broad range of age of onset. This report is now the largest case series of patients with CLCN2-related leucoencephalopathy and reinforces the finding that, although the imaging appearance is uniform, the phenotypic expression of this disorder is highly heterogeneous. Our findings expand the phenotypic spectrum of CLCN2-related leucoencephalopathy by adding prominent seizures, severe spastic paraplegia and developmental delay

Seminário de Dissertação (2024)

Página da disciplina de Seminário de Dissertação (MPPP, UFPE, 2022) Lista de participantes == https://docs.google.com/spreadsheets/d/1mrULe1y04yPxHUBaF50jhaM1OY8QYJ3zva4N4yvm198/edit#gid=

Brazilian Flora 2020: Leveraging the power of a collaborative scientific network

International audienceThe shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous countries worldwide have devoted considerable effort to Target 1 of the Global Strategy for Plant Conservation (GSPC), which called for the preparation of a working list of all known plant species by 2010 and an online world Flora by 2020. Brazil is a megadiverse country, home to more of the world's known plant species than any other country. Despite that, Flora Brasiliensis, concluded in 1906, was the last comprehensive treatment of the Brazilian flora. The lack of accurate estimates of the number of species of algae, fungi, and plants occurring in Brazil contributes to the prevailing taxonomic impediment and delays progress towards the GSPC targets. Over the past 12 years, a legion of taxonomists motivated to meet Target 1 of the GSPC, worked together to gather and integrate knowledge on the algal, plant, and fungal diversity of Brazil. Overall, a team of about 980 taxonomists joined efforts in a highly collaborative project that used cybertaxonomy to prepare an updated Flora of Brazil, showing the power of scientific collaboration to reach ambitious goals. This paper presents an overview of the Brazilian Flora 2020 and provides taxonomic and spatial updates on the algae, fungi, and plants found in one of the world's most biodiverse countries. We further identify collection gaps and summarize future goals that extend beyond 2020. Our results show that Brazil is home to 46,975 native species of algae, fungi, and plants, of which 19,669 are endemic to the country. The data compiled to date suggests that the Atlantic Rainforest might be the most diverse Brazilian domain for all plant groups except gymnosperms, which are most diverse in the Amazon. However, scientific knowledge of Brazilian diversity is still unequally distributed, with the Atlantic Rainforest and the Cerrado being the most intensively sampled and studied biomes in the country. In times of “scientific reductionism”, with botanical and mycological sciences suffering pervasive depreciation in recent decades, the first online Flora of Brazil 2020 significantly enhanced the quality and quantity of taxonomic data available for algae, fungi, and plants from Brazil. This project also made all the information freely available online, providing a firm foundation for future research and for the management, conservation, and sustainable use of the Brazilian funga and flora