Logística do Envelhecimento Ativo e Saudável: Um caso de estudo no concelho do Sabugal

No atual contexto social é, cada vez mais, uma necessidade a procura de novos e diferentes modelos e soluções de negócio, que promovam o sucesso nas Instituições do Terceiro Setor, porque estas permitem a conciliação da vida familiar com a profissional, bem como induzem a evolução social através de soluções inovadoras e tecnologicamente avançadas, que remetem os seus stakeholders para novas formas de negócio com valor económico. O envelhecimento ativo e saudável e a sua sustentabilidade é, indiscutivelmente, reconhecido pelas Instituições do Terceiro Setor como determinantes para o empreendedorismo social. Assim, o empreendedorismo social e o envelhecimento ativo e saudável são dois dos pilares da sociedade contemporânea que podem ultrapassar os aspetos mais turbulentos da mesma, tendo em consideração que os novos modelos de negócios procuram soluções cada vez mais rigorosas e inovadoras, provocando, assim, algum desequilíbrio em vários sectores como, por exemplo, no sector económico, social e ambiental. No entanto, estas Instituições do Terceiro Setor devem estabelecer alianças e parcerias de modo a promover soluções para o futuro. Nesta conjuntura, surge o presente projeto aplicado cujo foco de interesse é o Concelho do Sabugal, e que consiste em agregar as Instituições Particulares de Solidariedade Social (IPSS) desse concelho numa plataforma logística. Esta plataforma é desenvolvida através de um processo de rede integradora de conhecimentos e competências que permite aproveitar e potenciar os investimentos públicos e privados do Concelho do Sabugal. Assim, as infraestruturas e as estatísticas sobre o envelhecimento do Concelho permitem de forma equilibrada fixar a população aos territórios rurais e permitem preservar o património cultural e ambiental, bem como promover as suas atividades económicas tradicionais enquanto parceiras das novas estratégias económicas, em substituição das anteriores assentes no paradigma do mercado

Bioenergy from wastewater in a microbially-charged redox flow cell

Wastewater is a valuable renewable energy source to generate newest approaches for electrochemical energy conversion in bioelectrochemical system (BES) for energy storage devices. A BES to generate a bio-charging redox pair to be use as negalyte in a redox flow cell (RFC) was study. In BES 2,6-antraquinone was introduced as new redox pair (catholyte), where wastewater mixed communities were the anolyte for the generation of a bio-charged redox pair. The BES results indicated the reduction of the quinone (ca. 50 %), promoting power density ca. 10 mW m-2. A RFC with the bio-charged redox pair as negalyte and potassium hexacyanoferrate (III) as posilyte was tested, reaching ca. 100 % of coulombic efficiency, with potential and energy efficiencies ca. 60 %. Wastewater in the new microbiallycharged redox flow cell generate a clean energy that can be stored in a new landmark system.Portuguese Foundation for Science and Technology (FCT) of UID/BIO/04469 unit ,COMPETE 2020 (POCI-01-0145-FEDER-006684) and BioTecNorte operation (NORTE -01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020 -Programa Operacional Regional do Norte. The authors also acknowledge the Projects: i) POCI-01-0145-FEDER-006939 (LEPABE -Laboratory for Process Engineering, Environment, Biotechnology and Energy –UID/EQU/00511/2013),funded by the European Regional Development Fund (ERDF), through COMPETE2020 – Programa Operacional Competitividade e Internacionalização (POCI) and by nationals funds through FCT;ii) Projects"SunStorage -Harvesting and storage of solar energy", funded by European Regional Development Fund (ERDF), through COMPETE2020 -Operational Programme for Competitiveness and Internationalization (OPCI), by FCT, POCI-01-0145-FEDER-006939 -Laboratory for Process Engineering, Environment, Biotechnology and Energy –LEPABE, NORTE‐01‐0145‐FEDER‐000005 –LEPABE-2-ECO-INNOVATION, funded by FEDER funds through COMPETE2020 -OPCI and Operational Programme for North Region (NORTE2020) and by national funds through FCT, POCI-01-0145-FEDER-030510 – SunFlow -funded by FEDER funds through COMPETE2020 - POCI and by national funds (PIDDAC) through FCT/MCTESinfo:eu-repo/semantics/publishedVersio

Glycans as Key Checkpoints of T Cell Activity and Function

The immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulation of both innate and adaptive immune responses with important implications in the pathogenesis of major diseases such as autoimmunity and cancer. Glycans are implicated in fundamental cellular and molecular processes that regulate both stimulatory and inhibitory immune pathways. Besides being actively involved in pathogen recognition through interaction with glycan-binding proteins (such as C-type lectins), glycans have been also shown to regulate key pathophysiological steps within T cell biology such as T cell development and thymocyte selection; T cell activity and signaling as well as T cell differentiation and proliferation. These effects of glycans in T cells functions highlight their importance as determinants of either self-tolerance or T cell hyper-responsiveness which ultimately might be implicated in the creation of tolerogenic pathways in cancer or loss of immunological tolerance in autoimmunity. This review discusses how specific glycans (with a focus on N-linked glycans) act as regulators of T cell biology and their implications in disease

On the correlation between electronic intramolecular delocalization and Au-S bonding strength of ruthenium tetraammine SAMs

Trans-[Ru(L)(NH3)4(L’)](PF6)n type complexes, where L = 4-cyanopyridine (CNpy), NCS-, CN-, and L’ = CNpy, 1,4-dithiane (1,4-dt), 4-mercaptopyridine (pyS) and thionicotinamide (tna), were synthesized and characterized. SAMs on gold of the complexes containing sulfur were studied by reductive desorption and SERS spectroscopy. Depending on the nature of L’, the withdrawing capability of the CNpy ligand is strong enough to partially oxidize the ruthenium atom and, as a consequence, delocalize the s electronic density from the trans located ligand. The reductive desorption results showed that the stability of the SAMs is directly related to this effect