Systematic study of the response and calibration of the monitored drift tubes of the ATLAS muon spectrometer

The purpose of the work presented here is the study of the performance of the drift tubes of the ATLAS muon spectrometer. In particular, the analysis is focused on the development and optimization of the calibration tecnique, the study of the systematics involved and of the impact on the spatial resolution. That is the subject of the chapters from four to seven. It follows an analysis aimed the check for any evidence of degradation in the MDT preformance as a consequence of the extended exposure of the detector to the large particle flux during the accelerator operation. The first two chapters are dedicated to the description of the research program, the main characteristics of the experimental apparatus and the physical motivatons which have driven both the accelerator and the detector design with emphasis in the ATLAS Muon Spectrometer. The third chapter reviews the principles of operation of the drift tubes motivating the choice of the operating parameters of the ATLAS MDTs and the problematics related to the signal extraction. An overview of the experimental setups, the software tools and the analysis tecniques used can be found in chapter four

Two-particle correlations in azimuthal angle and pseudorapidity in inelastic p + p interactions at the CERN Super Proton Synchrotron

Results on two-particle ΔηΔϕ correlations in inelastic p + p interactions at 20, 31, 40, 80, and 158 GeV/c are presented. The measurements were performed using the large acceptance NA61/SHINE hadron spectrometer at the CERN Super Proton Synchrotron. The data show structures which can be attributed mainly to effects of resonance decays, momentum conservation, and quantum statistics. The results are compared with the Epos and UrQMD models.ISSN:1434-6044ISSN:1434-605

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Systematic study of the response and calibration of the Monitored Drift Tubes of the ATLAS Muon Spectrometer

The purpose of the work presented here is the study of the performance of the drift tubes of the ATLAS muon spectrometer. In particular, the analysis is focused on the development and optimization of the calibration tecnique, the study of the systematics involved and of the impact on the spatial resolution. That is the subject of the chapters from four to seven. It follows an analysis aimed the check for any evidence of degradation in the MDT preformance as a consequence of the extended exposure of the detector to the large particle flux during the accelerator operation. The first two chapters are dedicated to the description of the research program, the main characteristics of the experimental apparatus and the physical motivatons which have driven both the accelerator and the detector design with emphasis in the ATLAS Muon Spectrometer. The third chapter reviews the principles of operation of the drift tubes motivating the choice of the operating parameters of the ATLAS MDTs and the problematics related to the signal extraction. An overview of the experimental setups, the software tools and the analysis tecniques used can be found in chapter four

IT Lightning Talks: session #14

Which technology can help today improve Parkinson disease treatments, or age assessment for migrant children... and to improve waste management in refugee camps ? THEPort is solving urging humanitarian issue with technology since 2014. We will share with you what we have learnt so far and get you inspired to tackle the our upcoming challenges

Measurement of the single π0 production rate in neutral current neutrino interactions on water

The single π0 production rate in neutral current neutrino interactions on water in a neutrino beam with a peak neutrino energy of 0.6 GeV has been measured using the PØD, one of the subdetectors of the T2K near detector. The production rate was measured for data taking periods when the PØD contained water (2.64×1020 protons-on-target) and also periods without water (3.49×1020 protons-on-target). A measurement of the neutral current single π0 production rate on water is made using appropriate subtraction of the production rate with water in from the rate with water out of the target region. The subtraction analysis yields 106±41±69 signal events where the uncertainties are statistical (stat.) and systematic (sys.) respectively. This is consistent with the prediction of 157 events from the nominal simulation. The measured to expected ratio is 0.68±0.26(stat)±0.44(sys)±0.12(flux). The nominal simulation uses a flux integrated cross section of 7.63×10−39  cm2 per nucleon with an average neutrino interaction energy of 1.3 GeV.ISSN:1550-7998ISSN:0556-2821ISSN:1550-236

Multiplicity and transverse momentum fluctuations in inelastic proton–proton interactions at the CERN Super Proton Synchrotron

Measurements of multiplicity and transverse momentum fluctuations of charged particles were performed in inelastic p+p interactions at 20, 31, 40, 80, and 158 GeV /c beam momentum. Results for the scaled variance of the multiplicity distribution and for three strongly intensive measures of multiplicity and transverse momentum fluctuations Δ[PT,N], Σ[PT,N] and ΦpT are presented. For the first time the results on fluctuations are fully corrected for experimental biases. The results on multiplicity and transverse momentum fluctuations significantly deviate from expectations for the independent particle production. They also depend on charges of selected hadrons. The string-resonance Monte Carlo models Epos and Urqmd do not describe the data. The scaled variance of multiplicity fluctuations is significantly higher in inelastic p+p interactions than in central Pb+Pb collisions measured by NA49 at the same energy per nucleon. This is in qualitative disagreement with the predictions of the Wounded Nucleon Model. Within the statistical framework the enhanced multiplicity fluctuations in inelastic p+p interactions can be interpreted as due to event-by-event fluctuations of the fireball energy and/or volume.ISSN:1434-6044ISSN:1434-605

NA61/SHINE facility at the CERN SPS: beams and detector system

NA61/SHINE (SPS Heavy Ion and Neutrino Experiment) is a multi-purpose experimental facility to study hadron production in hadron-proton, hadron-nucleus and nucleus-nucleus collisions at the CERN Super Proton Synchrotron. It recorded the first physics data with hadron beams in 2009 and with ion beams (secondary 7Be beams) in 2011. NA61/SHINE has greatly profited from the long development of the CERN proton and ion sources and the accelerator chain as well as the H2 beamline of the CERN North Area. The latter has recently been modified to also serve as a fragment separator as needed to produce the Be beams for NA61/SHINE. Numerous components of the NA61/SHINE set-up were inherited from its predecessors, in particular, the last one, the NA49 experiment. Important new detectors and upgrades of the legacy equipment were introduced by the NA61/SHINE Collaboration. This paper describes the state of the NA61/SHINE facility – the beams and the detector system – before the CERN Long Shutdown I, which started in March 2013.ISSN:1748-022

Production of Λ -hyperons in inelastic p+p interactions at 158 GeV/c

Inclusive production of Λ-hyperons was measured with the large acceptance NA61/SHINE spectrometer at the CERN SPS in inelastic p+p interactions at beam momentum of 158 GeV/c. Spectra of transverse momentum and transverse mass as well as distributions of rapidity and xF are presented. The mean multiplicity was estimated to be 0.120±0.006(stat.)±0.010(sys.). The results are compared with previous measurements and predictions of the Epos, Urqmd and Fritiof models.ISSN:1434-6044ISSN:1434-605