Clinical and Genetic Risk Factors Associated with Psoriatic Arthritis among Patients with Psoriasis.

IntroductionPsoriatic arthritis (PsA) is a chronic, inflammatory arthritis that affects an estimated 30% of patients with psoriasis. PsA is underdiagnosed in primary care and dermatology clinics due to a variety of reasons, including failure of healthcare providers to ask about symptoms, overlap of symptoms and signs with other rheumatologic conditions, and lack of a specific diagnostic test. A delay in PsA diagnosis and treatment, even as short as 6 months, can lead to decreased quality of life, increased joint damage, and worse long-term physical function. In this study, we sought to identify the clinical and genetic factors that help discriminate patients with PsA from those with cutaneous psoriasis only.MethodsWe analyzed a cohort of 974 psoriasis patients at an academic medical center, of whom 175 had confirmed PsA, and performed univariate, multivariate, and predictive modeling to determine factors associated with PsA.ResultsThe univariate analysis revealed significant positive associations of PsA with age, nail involvement, scalp involvement, skin fold involvement, elbow/knee involvement, psoriasis severity, plaque subtype, erythrodermic subtype, hypertension, type 2 diabetes, and coronary artery disease, and a significant negative association of PsA with the human leukocyte antigen (HLA)-C*06:02 allele. In the multivariate analysis, nail involvement, type 2 diabetes, and pustular psoriasis remained significantly associated with PsA, while HLA-C*06:02 positivity remained protective. There was a trend towards an association of PsA with older age, younger age of psoriasis onset, and skin fold involvement, while there was protective trend for smoking. A predictive model including both clinical and genetic factors showed reasonable discriminative ability between psoriasis and PsA, with an area under the curve of 0.87 for a receiver operating characteristic curve.ConclusionThis study identified a number of clinical and genetic features that could help stratify patients who are at higher risk for having PsA and for whom rheumatology referral may be beneficial

An Examination of the Benefits of Scalable TTI for Heterogeneous Traffic Management in 5G Networks

The rapid growth in the number and variety of connected devices requires 5G wireless systems to cope with a very heterogeneous traffic mix. As a consequence, the use of a fixed TTI during transmission is not necessarily the most efficacious method when heterogeneous traffic types need to be simultaneously serviced.This work analyzes the benefits of scheduling based on exploiting scalable TTI, where the channel assignment and the TTI duration are adapted to the deadlines and requirements of different services. We formulate an optimization problem by taking individual service requirements into consideration. We then prove that the optimization problem is NP-hard and provide a heuristic algorithm, which provides an effective solution to the problem. Numerical results show that our proposed algorithm is capable of finding near-optimal solutions to meet the latency requirements of mission critical communication services, while providing a good throughput performance for mobile broadband services.Comment: RAWNET Workshop, WiOpt 201

The metabolomics of psoriatic disease.

Metabolomics is an emerging new "omics" field involving the systematic analysis of the metabolites in a biologic system. These metabolites provide a molecular snapshot of cellular activity and are thus important for understanding the functional changes in metabolic pathways that drive disease. Recently, metabolomics has been used to study the local and systemic metabolic changes in psoriasis and its cardiometabolic comorbidities. Such studies have revealed novel insights into disease pathogenesis and suggest new biochemical signatures that may be used as a marker of psoriatic disease. This review will discuss common strategies in metabolomics analysis, current findings in the metabolomics of psoriasis, and emerging trends in psoriatic metabolomics

Integrable N=2 Supersymmetric Field Theories

Some additional references are included on the last 3 pages.Comment: 14 pages, OUTP-92-12

Axial Vector Couplings of the Nucleon in Chiral Quark Model Incorporating U(1)A U(1)_A Anomaly Effects

Renormalization of the axial vector currents due to Goldstone loops is studied in a simple extension of Manohar - Georgi chiral quark model which incorporates $U(1)_A$ anomaly effects. The polarized strage quark sea in the polarized nucleon results from different renormalization of the flavor singlet and octet currents and is in reasonable agreement with the experiment.Comment: 11 pages REVtex, 2 figures sent upon reques

Resource Optimization with Flexible Numerology and Frame Structure for Heterogeneous Services

We explore the potential of optimizing resource allocation with flexible numerology in frequency domain and variable frame structure in time domain, in presence of services with different types of requirements. We analyze the computational complexity and propose a scalable optimization algorithm based on searching in both the primal space and dual space that are complementary to each other. Numerical results show significant advantages of adopting flexibility in both time and frequency domains for capacity enhancement and meeting the requirements of mission critical services.Comment: 4 page

Spin chirality fluctuation in two-dimensional ferromagnets with perpendicular anisotropy

Non-coplanar spin textures with scalar spin chirality can generate effective magnetic field that deflects the motion of charge carriers, resulting in topological Hall effect (THE), a powerful probe of the ground state and low-energy excitations of correlated systems. However, spin chirality fluctuation in two-dimensional ferromagnets with perpendicular anisotropy has not been considered in prior studies. Herein, we report direct evidence of universal spin chirality fluctuation by probing the THE above the transition temperatures in two different ferromagnetic ultra-thin films, SrRuO$_3$ and V doped Sb$_2$Te$_3$. The temperature, magnetic field, thickness, and carrier type dependences of the THE signal, along with our Monte-Carlo simulations, unambiguously demonstrate that the spin chirality fluctuation is a universal phenomenon in two-dimensional Ising ferromagnets. Our discovery opens a new paradigm of exploring the spin chirality with topological Hall transport in two-dimensional magnets and beyondComment: accepted by nature material

Noncommutative QCD corrections to the gluonic decays of heavy quarkonia

We compute the Noncommutative QCD (NCQCD) contributions to the three gluon decay modes of heavy quarkonia. For triplet quarkonia (ortho-quarkonia), the NCQCD correction to the QCD three gluon decay mode, like the standard model contribution, is infrared finite. In the case of singlet quarkonia (para-quarkonia), whose QCD three gluon decay mode has infrared singularities which are removed using one-loop corrections to the two gluon mode, we find that NCQCD contribution is also infrared finite. The calculations are performed in the weak binding limit and do not require the introduction of additional effective couplings.Comment: Version accepted for publicatio