Niosome: The Magic Bullet

Target oriented drug delivery systems are the areas of the major interest in the modern pharmaceutical research. The selective drug delivery to the target tissues increases the therapeutic efficacy of the drug and reduces its undesirable effect to non target tissues.The concept of drug targeting or site specific drug delivery was introduced first time by Paul Elrich in 1909, when he reported magic bullet to deliver a drug to the desired site of action without affecting the non target organs or tissues (Juliano, 1980) by associating the drug with a pharmacologically “inactive carrier capable of conveying the drug selectively towards its target cells. Niosomes or nonionic surfactant vesicles are microscopic lamellar structures formed on admixture of nonionic surfactant of the alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. In niosomes, the vesicles forming amphiphile is a nonionic surfactant such as span 60 which is usually stabilized by addition of cholesterol and small amount of anionic surfactant such as dicetyl phosphate. Niosomes can entrap both hydrophilic and lipophilic drugs, either in aqueous layer or in vesicular membrane made of lipid materials. It is reported to attain better stability than liposomes. It can prolong the circulation of the entrapped drugs. Because of the presence of nonionic surfactant with the lipid, there is better targeting of drugs to tumour, liver and brain. It may prove very useful for targeting the drug for treating cancers, parasitic, viral and other microbial disease more effectively. Key-Words: magic bullet, Target oriented drug delivery systems, inactive carrier, Niosome, site specific drug delivery, liposomes, cancers

Niosome: A Novel Drug Delivery System

The concept of drug targeting or site specific drug delivery was introduced first time by Paul Elrich in 1909, when he reported magic bullet to deliver a drug to the desired site of action without affecting the non target organs or tissues (Juliano, 1980) by associating the drug with a pharmacologically inactive carrier capable of conveying the drug selectively towards its target cells. The main goal of a site specific drug delivery system is not only to increase the selectivity and drug therapeutic index, but also to reduce the toxicity of the drug

A Review on study of Buccal Drug Delivery System

Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules. However, the need for safe and effective buccal permeation absorption enhancers is a crucial component for a prospective future in the area of buccal drug delivery. Buccal nitroglycerin, can use for acute therapy for an animal attack as well as for chronic prophylaxis Novel liquid aerosol formulation of insulin Development of suitable delivery devices, permeation enhancement, and Buccal delivery of drugs that undergo a first-pass effect, such as cardiovascular drugs, analgesics, and peptides Research yield some successes Promote further research; more companies Rest depend on delivery technolog