Effect of Types of Fluids on Fluid Flow Characteristics in Bifurcated Vessel using CFD Simulation

The present study focuses on the CFD analysis of bifurcated blood vessel using ABAQUS /CFD 6.14 software in order to investigate the effect of types of fluids on resultant velocity and axial velocities of flow. It has been found that out of resultant velocity and axial velocity in three mutually perpendicular directions, types of fluids have significant influence on velocity in z-direction. A significant increment of nearly 45 % in maximum velocity in z-direction has been obtained from benzene to Newtonian blood

Geologic Influence on Radon Concentrations Levels in Cave: A Case Study of Mimpi Cave in the Maros Karst of South Sulawesi, Indonesia

Radon gas in the natural environment mainly comes from the release of local bedrock geology and easily accumulate in closed spaces such as basements and caves. This study was performed to investigate the radon concentrations in Mimpi Cave, Bantimurung-Bulusaraung National Park, in the Maros karst area, South Sulawesi, and discussed a possible relationship between the radon concentrations and the local geology. Measurements were carried out using a passive detection technique with CR-39 nuclear tracks detectors by exposing it for a period of three months. The 222Rn levels measured inside the cave ranges from 64.03 Bq m‑3 to 3396.02 Bq m‑3, with an average value of 1075.05 Bq m‑3.The results are comparable with radon concentration in different caves environments reported from other surveys in several countries. Geological background of the Maros Karst areas could sustain the measured radon values, due to the presence of limestone rock with a mineral composition which can lead to higher radon concentrations in Mimpi Cave

Hypothermia for encephalopathy in low-income and middle-income countries: feasibility of whole-body cooling using a low-cost servo-controlled device

Although therapeutic hypothermia (TH) is the standard of care for hypoxic ischaemic encephalopathy in high-income countries, the safety and efficacy of this therapy in low-income and middle-income countries (LMICs) is unknown. We aimed to describe the feasibility of TH using a low-cost servo-controlled cooling device and the short-term outcomes of the cooled babies in LMIC. Design: We recruited babies with moderate or severe hypoxic ischaemic encephalopathy (aged <6 hours) admitted to public sector tertiary neonatal units in India over a 28-month period. We administered whole-body cooling (set core temperature 33.5°C) using a servo-controlled device for 72 hours, followed by passive rewarming. We collected the data on short-term neonatal outcomes prior to hospital discharge. Results: Eighty-two babies were included-61 (74%) had moderate and 21 (26%) had severe encephalopathy. Mean (SD) hypothermia cooling induction time was 1.7 hour (1.5) and the effective cooling time 95% (0.08). The mean (SD) hypothermia induction time was 1.7 hour (1.5 hour), core temperature during cooling was 33.4°C (0.2), rewarming rate was 0.34°C (0.16°C) per hour and the effective cooling time was 95% (8%). Twenty-five (51%) babies had gastric bleeds, 6 (12%) had pulmonary bleeds and 21 (27%) had meconium on delivery. Fifteen (18%) babies died before discharge from hospital. Heart rate more than 120 bpm during cooling (P=0.01) and gastric bleeds (P<0.001) were associated with neonatal mortality. Conclusions: The low-cost servo-controlled cooling device maintained the core temperature well within the target range. Adequately powered clinical trials are required to establish the safety and efficacy of TH in LMICs. Clinical trial registration number: NCT01760629

Hypothermia for encephalopathy in low and middle-income countries (HELIX): Study protocol for a randomised controlled trial

BACKGROUND: Therapeutic hypothermia reduces death and disability after moderate or severe neonatal encephalopathy in high-income countries and is used as standard therapy in these settings. However, the safety and efficacy of cooling therapy in low- and middle-income countries (LMICs), where 99% of the disease burden occurs, remains unclear. We will examine whether whole body cooling reduces death or neurodisability at 18-22 months after neonatal encephalopathy, in LMICs. METHODS: We will randomly allocate 408 term or near-term babies (aged ≤ 6 h) with moderate or severe neonatal encephalopathy admitted to public sector neonatal units in LMIC countries (India, Bangladesh or Sri Lanka), to either usual care alone or whole-body cooling with usual care. Babies allocated to the cooling arm will have core body temperature maintained at 33.5 °C using a servo-controlled cooling device for 72 h, followed by re-warming at 0.5 °C per hour. All babies will have detailed infection screening at the time of recruitment and 3 Telsa cerebral magnetic resonance imaging and spectroscopy at 1-2 weeks after birth. Our primary endpoint is death or moderate or severe disability at the age of 18 months. DISCUSSION: Upon completion, HELIX will be the largest cooling trial in neonatal encephalopathy and will provide a definitive answer regarding the safety and efficacy of cooling therapy for neonatal encephalopathy in LMICs. The trial will also provide important data about the influence of co-existent perinatal infection on the efficacy of hypothermic neuroprotection. TRIAL REGISTRATION: ClinicalTrials.gov, NCT02387385. Registered on 27 February 2015

Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh

Background: Although therapeutic hypothermia reduces death or disability after neonatal encephalopathy in high-income countries, its safety and efficacy in low-income and middle-income countries is unclear. We aimed to examine whether therapeutic hypothermia alongside optimal supportive intensive care reduces death or moderate or severe disability after neonatal encephalopathy in south Asia. Methods: We did a multicountry open-label, randomised controlled trial in seven tertiary neonatal intensive care units in India, Sri Lanka, and Bangladesh. We enrolled infants born at or after 36 weeks of gestation with moderate or severe neonatal encephalopathy and a need for continued resuscitation at 5 min of age or an Apgar score of less than 6 at 5 min of age (for babies born in a hospital), or both, or an absence of crying by 5 min of age (for babies born at home). Using a web-based randomisation system, we allocated infants into a group receiving whole body hypothermia (33·5°C) for 72 h using a servo-controlled cooling device, or to usual care (control group), within 6 h of birth. All recruiting sites had facilities for invasive ventilation, cardiovascular support, and access to 3 Tesla MRI scanners and spectroscopy. Masking of the intervention was not possible, but those involved in the magnetic resonance biomarker analysis and neurodevelopmental outcome assessments were masked to the allocation. The primary outcome was a combined endpoint of death or moderate or severe disability at 18–22 months, assessed by the Bayley Scales of Infant and Toddler Development (third edition) and a detailed neurological examination. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, NCT02387385. Findings: We screened 2296 infants between Aug 15, 2015, and Feb 15, 2019, of whom 576 infants were eligible for inclusion. After exclusions, we recruited 408 eligible infants and we assigned 202 to the hypothermia group and 206 to the control group. Primary outcome data were available for 195 (97%) of the 202 infants in the hypothermia group and 199 (97%) of the 206 control group infants. 98 (50%) infants in the hypothermia group and 94 (47%) infants in the control group died or had a moderate or severe disability (risk ratio 1·06; 95% CI 0·87–1·30; p=0·55). 84 infants (42%) in the hypothermia group and 63 (31%; p=0·022) infants in the control group died, of whom 72 (36%) and 49 (24%; p=0·0087) died during neonatal hospitalisation. Five serious adverse events were reported: three in the hypothermia group (one hospital readmission relating to pneumonia, one septic arthritis, and one suspected venous thrombosis), and two in the control group (one related to desaturations during MRI and other because of endotracheal tube displacement during transport for MRI). No adverse events were considered causally related to the study intervention. Interpretation: Therapeutic hypothermia did not reduce the combined outcome of death or disability at 18 months after neonatal encephalopathy in low-income and middle-income countries, but significantly increased death alone. Therapeutic hypothermia should not be offered as treatment for neonatal encephalopathy in low-income and middle-income countries, even when tertiary neonatal intensive care facilities are available. Funding: National Institute for Health Research, Garfield Weston Foundation, and Bill & Melinda Gates Foundation. Translations: For the Hindi, Malayalam, Telugu, Kannada, Singhalese, Tamil, Marathi and Bangla translations of the abstract see Supplementary Materials section

Effect of Types of Fluids on Fluid Flow Characteristics in Bifurcated Vessel using CFD Simulation

25-28The present study focuses on the CFD analysis of bifurcated blood vessel using ABAQUS /CFD 6.14 software in order to investigate the effect of types of fluids on resultant velocity and axial velocities of flow. It has been found that out of resultant velocity and axial velocity in three mutually perpendicular directions, types of fluids have significant influence on velocity in z-direction. A significant increment of nearly 45 % in maximum velocity in z-direction has been obtained from benzene to Newtonian blood

Perbandingan Algoritma Winnowing Dan Algoritma Manber Dalam Mendeteksi Berita Hoax Di Media Sosial

Saat ini berbagai Informasi dapat beredar dengan cepat dan luas dari berbagai belahan dunia melalui Internet. Kemudahan untuk mengakses internet yang sudah bisa dinikmati di mana saja merupakan salah satu faktor utama yang menyebabkan informasi dapat dengan mudah diperoleh. Namun, dikarenakan kemudahan informasi yang didapat tersebut, tidak sedikit tindak kejahatan yang terjadi di dunia maya contohnya adalah Berita Hoax. salah satu kategori hoaks yang berbahaya dan banyak terjadi di kalangan pengguna media sosial yaitu kategori konten false, konten ini sangat menipu masyarakat. Sistem deteksi hoaks juga mampu memberikan informasi Penggunaan Web Sistem deteksi berita hoaks sebagai sarana dalam membandingkan algoritma Winnowing dan Manber sangat praktis dan sebagai solusi, serta mampu menangkal isu-isu berita hoaks yang beredar di kalangan pengguna media sosial dan meningkatkan intelektual kepada masyarakat agar tidak mudah percaya dengan pemberitaan yang menyesatkan. Dari algoritma winnowing dan Manber informasi menemukan perbandingan keefektifan langkah dan pengaruh jumlah parameter dalam menghitung kesamaan teks berita hoaks yang di uji. Hasil persentase 65% dari segi kecepatan maka Manber lebih baik dari pada Winnowing karena Manber memliki langkah lebih sedikit dalam mencari nilai Persentase kesamaan teks berita hoaks yang di uji. Perbandingan dari segi ketepatan yang di dapat adalah winnowing lebih baik dari pada manber di karenakan winnowing lebih akurat pada langkah pemilihan nilai windows terkecil sehingga mendapatkan nilai persentase yang lebih akurat