13 research outputs found
Neglected, semimembranosus osteochondral avulsion fracture of the posteromedial tibial plateau
Semimembranosus avulsion fracture is infrequently reported and is easy to miss on plain radiographs; the mechanism of injury is highly controversial. Initial reports linked it to anterior cruciate ligament and medial meniscal tears. We report an osteochondral semimembranosus avulsion fracture of the posteromedial tibial plateau with associated posterior cruciate ligament rupture. Also described is a novel surgical fixation technique for such osteochondral fractures where the surgical exposure is limited due to the obliquity of the fracture line resulting in a greater involvement of the articular cartilage than the small bony component. The fixation technique described may be used for osteochondral fractures where the application of a conventional compression screw may not be feasible. Keywords: Osteochondral fracture, Semimembranosus avulsion fracture, Posteromedial tibial plateau, Neglected, Nonunio
Reconstruction of chronic acromioclavicular joint disruption with artificial ligament prosthesis
【Abstract】Objective: Management of Rockwood
type 3 acromioclavicular disruptions is a matter of debate.
Should we adopt conservative or operative measures at first
presentation? It is not clear but most of the evidences are in
favour of conservative management. We present our expe-rience in managing these patients surgically.
Methods: We present a prospective series of eight
cases of chronic Rockwood type 3 acromioclavicular joint
disruptions treated surgically. Anatomical reconstruction
of the coracoclavicular ligament was done by artificial
braided polyester ligament prosthesis.
Results: All the patients were able to perform daily
activities from an average of the 14th postoperative day. All
patients felt an improvement in pain, with decrease in ave-rage visual analogue scale from preoperative 6.5 points
(range 3-9 points) to 2.0 points (range 0-5 points), Constant
score from 59% to 91% and American Shoulder and Elbow
Surgeons shoulder score from 65 to 93 points postoperatively.
These results improved or at least remained stationary on
midterm follow-up, and no deterioration was recorded at an
average follow-up of 46 months.
Conclusion: This midterm outcome analysis of the
artificial ligament prosthesis is the first such follow-up study
with prosthesis. Our results are encouraging and justify the
further use and evaluation of this relatively new and easily
reproducible technique.
Key words: Acromioclavicular joint; Prostheses and
implants; Reconstructive surgical procedures; Ligament
Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent
Several options for treating Herpes Simplex Virus type 1 and type 2 are available. However, non-specific inhibition and drug resistance warrants the discovery of new anti-herpetic compounds with better therapeutic profile or different mode of action. The non-nucleoside inhibitors of HSV DNA polymerase target the site that is less important for the binding of a natural nucleoside or nucleoside inhibitors. In the present study, we have explored the possibility to find a new lead molecule based on α-pyrone analogs as non-nucleoside inhibitors using structure based modeling approach. The designed molecules were synthesized and evaluated for anti-HSV activity using MTT assay. The compound 5h with EC<SUB>50</SUB> 7.4 μg/ml and CC<SUB>50</SUB> 52.5 μg/ml was moderately active against HSV when compared to acyclovir. A plaque reduction assay was also carried out and results reveal that 5h is more effective against HSV-1 with better selective index of 12.8 than against HSV-2 (SI = 3.6). The synthesized compounds were also evaluated for anti-HIV activity, but none were active