Het decreet rechtspositie minderjarigen in internationaal perspectief

Deze studie plaatst het Decreet betreffende de Rechtspositie van de Minderjarige in de integrale jeugdhulp (DRM) van 7 mei 2004 in internationaal perspectief, en toetst het decreet aan een aantal instrumenten van internationaal recht

Why network coherent data is smart

Voltage and current data time stamped within sufficient time-uncertainty allow smart opportunities in network operation. The usefulness of network coherent data is demonstrated by means of two case studies. It is shown that synchrophasors could further additional network performance information on renewable sources of energy integrated at distribution voltage levels. On-line modelling is an additional smart opportunity made possible by PQ instrumentation if designed according to the latest draft of the IEC 61000-4-30 Class requirements

Maximum power injection acceptance in a residential area

The number of installed distributed generation (DG) in residential areas rapidly increases, specifically in the form of photovoltaics (PV), causing some undesired side effects such as voltage rise. Overvoltage can damage critical loads, but is also disadvantageous for the owner because inverters switch off in case of overvoltage, resulting in output loss. Voltage limits are investigated through calculation and simulation of the voltage profile in a typical low voltage (LV) grid by using load data. Insolation data is used for the particular case of PV. This paper presents practical guidelines for the maximum power acceptance in a residential distribution network and the estimation of PV production loss due to overvoltage

Introducing small storage capacity at residential PV installations to prevent overvoltages

Low voltage distribution feeders are designed for unidirectional energy supply from transformer to consumer. However, the implementation of small-scale PV production units on local utilities may result in bidirectional energy flows. The simultaneous power injection at sunny moments may cause a serious voltage rise along the feeder. These overvoltages may not only damage critical loads but also switches PV inverters off causing loss of green energy at the most productive moments. This paper presents a method to limit the voltage rise by introducing small battery buffers at local production sites. A smart inverter decides whether the PV energy is injected in the grid or buffered in the batteries. The relation between battery buffer size and overvoltage reduction is presented for a typical Belgian residential distribution feeder. The influence of the buffer along the feeder is calculated by working with synthetic load profiles and solar irradiation data

Synthesis, trehalase hydrolytic resistance and inhibition properties of 4-and 6-substituted trehalose derivatives

Although trehalose has recently gained interest because of its pharmaceutical potential, its clinical use is hampered due to its low bioavailability. Hence, hydrolysis-resistant trehalose analogues retaining biological activity could be of interest. In this study, 34 4- and 6-O-substituted trehalose derivatives were synthesised using an ether- or carbamate-type linkage. Their hydrolysis susceptibility and inhibitory properties were determined against two trehalases, i.e. porcine kidney and Mycobacterium smegmatis. With the exception of three weakly hydrolysable 6-O-alkyl derivatives, the compounds generally showed to be completely resistant. Moreover, a number of derivatives was shown to be an inhibitor of one or both of these trehalases. For the strongest inhibitors of porcine kidney trehalase IC50 values of around 10 mM could be determined, whereas several compounds displayed sub-mM IC50 against M. smegmatis trehalase. Dockings studies were performed to explain the observed influence of the substitution pattern on the inhibitory activity towards porcine kidney trehalase

Structural basis of IL-23 antagonism by an Alphabody protein scaffold

Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-chain antiparallel triple-helix coiled-coil fold. We report affinity-matured Alphabodies with favourable physicochemical properties that can specifically neutralize human interleukin (IL)-23, a pivotal therapeutic target in autoimmune inflammatory diseases such as psoriasis and multiple sclerosis. The crystal structure of human IL-23 in complex with an affinity-matured Alphabody reveals how the variable interhelical groove of the scaffold uniquely targets a large epitope on the p19 subunit of IL-23 to harness fully the hydrophobic and hydrogen-bonding potential of tryptophan and tyrosine residues contributed by p19 and the Alphabody, respectively. Thus, Alphabodies are suitable for targeting protein-protein interfaces of therapeutic importance and can be tailored to interrogate desired design and binding-mode principles via efficient selection and affinity-maturation strategies

Segregation of rol genes in two generations of Sinningia speciosa engineered through wild type Rhizobium rhizogenes

Rhizobium rhizogenes infects and transforms a wide range of plant species. It thereby introduces new genes located on transfer-DNA of the root inducing plasmid (pRi) into the plant genome and one of its abilities is to alter the host root system. Explants from pRi transformed roots from Sinningia speciosa were regenerated to create naturally transgenic Ri lines. The presence of rol and aux genes in the Ri lines was linked with altered growth characteristics: shorter peduncles, wrinkled leaves, delayed flowering and enhanced root growth. The potential of Ri lines for breeding was evaluated through consecutive backcrossing with the original host genotype. The progeny of reciprocal crosses showed non-Mendelian inheritance suggesting partial transmission of the of the aux and rol genes. The typical Ri phenotype observed in the primary Ri line was partially inherited. These results revealed that the Ri phenotype is a complex trait influenced by the genetic background of the Ri line

Rational design of an improved transglucosylase for production of the rare sugar nigerose

The sucrose phosphorylase from Bifidobacterium adolescentis (BaSP) can be used as a transglucosylase for the production of rare sugars. We designed variants of BaSP for the efficient synthesis of nigerose from sucrose and glucose, thereby adding to the inventory of rare sugars that can conveniently be produced from bulk sugars