The Fight for Freedom of Two Oppressed Groups: Indian Nationalism and African American Liberation

This study examines the activities of two revolutionaries, one Lala Har Dayal (1884-1939) who established in the U.S. the Ghadar Party as an Indian revolutionary party against the British rule in India and the other was Huey P. Newton (1942-1989) who was a founder of the Black Panther Party which violently agitated against the longstanding chokehold of the “White” rule over the African American people. Juxtaposing the two different time periods and two different continents, which are incompatible phenomena give further understanding of what caused both such movements, regarded as aggressive resistance by their peoples to their oppressive rulers, to be effectively incapable of bringing even a modicum of freedom for their peoples from chokeholds of their respective oppressive rulers. Hardayal, came to San Francisco in 1911 to work in Berkley as a lecturer in Indian Philosophy and Sanskrit. At this time, he became a cofounder of Ghadar Party which became an Indian nationalist party. The party instructed on bomb-making and the use of explosives to the Indian nationalists in in India through publications in a newspaper, edited by Hardayal. In April 1914, upon pressure from the British government, the American Government arrested him for radical publications. But Hardayal was freed on a bail and he escaped to Europe. Later on, Har Dayal returned to Oxford and received his Ph.D. degree in 1930. Huye P. Newton (1942-1989) was born on 1942 in Monroe, Louisiana. As a child, he moved to Oakland, California, with his family. In the mid1960s, he met Bobby Seal. Both of them created the Black Panther Party for Self Defense in 1966. They created the Ten-Point Program, which demanded better housing, employment, and education. They also wanted to stop police brutality against the public. They were combative in their actions. In 1967 Newton was arrested for supposedly killing a Police officer in Oakland. In the 1970s Black Panther Party began to disintegrate because of the disputes among the members. In 1974, Newton faced more criminal charges, and he fled to Cuba. He returned to the States in 1977 and went back to UC Santa Cruz and received his Ph.D. in Social Philosophy in 1980. In August 1989, he was shot on the street of Oakland and died. The two revolutionaries were highly educated individuals and widely traveled across the world to nurture their own views about finding a means to find relief for their own people against oppressions from the ruling power. They both advocated adoption of aggressive paths to achieve freedom for their people from the hold of the oppressive ruler. Recapturing together the ultimate fates of failures met by the two aggressive revolutionary movements, led by Har Dayal and Huey P. Newton, uncover an important fact that both the rulers have European cultural origin. This European cultural origin helped these two white groups assume a culturally superior position. Both movements for freedom, lasting only briefly without bringing any significant success to its ultimate mission, developed from a longstanding popular passive movement. The aims of Ghadar Party and Black Panther Party, although differing from each other in many ways, had one very significant common link that they were fighting against the oppressors with European cultural origin The general public from both groups rejected the violent movements and adopt a passive movement against their oppressors as a way to overcome their own conceived cultural inferiority status

BLOOD FLOW RESTRICTION DOES NOT AFFECT ACUTE MEASURES OF POWER AND FATIGUE DURING MAXIMAL CYCLING AMONG WOMEN

While it is known that blood flow restriction (BFR) can positively affect training and rehabilitation progression timelines, the physiological basis of this intervention is not fully understood. The purpose of this study was to determine the short-term impact of BFR upon power and fatigue performance measures during maximal cycling. In this study, maximal cycling was assessed using the Wingate Anaerobic Test (WAnT). Using a counterbalanced design, fourteen female participants completed standardized BFR and non-BFR protocols while completing the WAnT. No statistically-significant differences (p ≤ 0.05) were found between conditions for measures of peak power (PP), low power (LP) or fatigue index (FI). These findings suggest that BFR had no statistically-significant acute effect on these performance measures commonly assessed during the WAnT

THE EFFECTS OF BLOOD FLOW RESTRICTION ON MEASURES OF GROSS MOTOR COORDINATION DURING THE WINGATE ANAEROBIC TEST

To date little research has addressed the impact of blood flow restriction (BFR) training upon gross motor coordination measures (GMCM) during a wide variety of maximal activities. The purpose of this study was to assess the effects of BFR on GMCM exhibited during maximal cycling. The performance of 14 females between the ages of eighteen and thirty-five were analyzed during the Wingate Anaerobic Test (WAnT). The participants completed the test under two conditions, using BFR and without. Results showed statistically significant differences (p ≤ 0.05) between conditions for dependent variables assessed throughout this common 30 second test of maximal cycling. These findings suggest that BFR negatively influenced GMCM exhibited during the WAnT

Personalizing dental screening and prevention protocols in dentulous patients with oropharyngeal cancer undergoing radiotherapy:A retrospective cohort study

Objectives:Patients with head and neck cancer are routinely screened for dental foci prior to radiotherapy (RT) to prevent post- RT tooth extractions associated with an increased risk of osteoradionecrosis. We evaluated the risk factors for post-RT tooth extraction to personalise dental screening and prevention protocols prior to RT. Materials and methods: This retrospective cohort study included dentulous patients diagnosed with oropharyngeal cancer who had undergone radiation therapy at doses 60–70 Gy and achieved a disease-free survival of ≥ 1 year (N = 174). Risk factors were assessed using Cox regression models. Results: The cumulative incidence of post-RT tooth extraction was 30.7 % at 5 years. Main indications for extraction (n = 62) were radiation caries (n = 20) and periodontal disease (n = 27). Risk factors associated (p &lt; 0.05) with radiation caries-related extractions included active smoking, alcohol abuse, poor oral hygiene, parotid gland irradiation, and mandibular irradiation. A high-dose volume in the mandible was associated with periodontal disease events. Conclusion: Post-RT extractions due to radiation caries were influenced by lifestyle factors and RT dose in the mandible and parotid glands. Periodontal disease-related extractions were primarily associated with the mandibular dose. During dental screening these post-RT risk factors should be taken into account to prevent osteoradionecrosis.</p

Black Rap 2020 v.1 issue 2

https://publications.lakeforest.edu/black_rap/1001/thumbnail.jp

Time Delay Lens Modelling Challenge

In recent years, breakthroughs in methods and data have enabled gravitational time delays to emerge as a very powerful tool to measure the Hubble constant $H_0$. However, published state-of-the-art analyses require of order 1 year of expert investigator time and up to a million hours of computing time per system. Furthermore, as precision improves, it is crucial to identify and mitigate systematic uncertainties. With this time delay lens modelling challenge we aim to assess the level of precision and accuracy of the modelling techniques that are currently fast enough to handle of order 50 lenses, via the blind analysis of simulated datasets. The results in Rung 1 and Rung 2 show that methods that use only the point source positions tend to have lower precision ($10 - 20\%$) while remaining accurate. In Rung 2, the methods that exploit the full information of the imaging and kinematic datasets can recover $H_0$ within the target accuracy ($|A| < 2\%$) and precision ($< 6\%$ per system), even in the presence of poorly known point spread function and complex source morphology. A post-unblinding analysis of Rung 3 showed the numerical precision of the ray-traced cosmological simulations to be insufficient to test lens modelling methodology at the percent level, making the results difficult to interpret. A new challenge with improved simulations is needed to make further progress in the investigation of systematic uncertainties. For completeness, we present the Rung 3 results in an appendix, and use them to discuss various approaches to mitigating against similar subtle data generation effects in future blind challenges.Comment: 23 pages, 12 figures, 6 tables, MNRAS accepte

The economics of debt clearing mechanisms

We examine the evolution of decentralized clearinghouse mechanisms from the 13th to the 18th century; in particular, we explore the clearing of non- or limitedtradable debts like bills of exchange. We construct a theoretical model of these clearinghouse mechanisms, similar to the models in the theoretical matching literature, and show that specific decentralized multilateral clearing algorithms known as rescontre, skontrieren or virement des parties used by merchants were efficient in specific historical contexts. We can explain both the evolutionary self-organizing emergence of late medieval and early modern fairs, and its robustness during the 17th and 18th century

The Two Caenorhabditis elegans UDP-Glucose:Glycoprotein Glucosyltransferase Homologues Have Distinct Biological Functions

The UDP-Glc:glycoprotein glucosyltransferase (UGGT) is the sensor of glycoprotein conformations in the glycoprotein folding quality control as it exclusively glucosylates glycoproteins not displaying their native conformations. Monoglucosylated glycoproteins thus formed may interact with the lectin-chaperones calnexin (CNX) and calreticulin (CRT). This interaction prevents premature exit of folding intermediates to the Golgi and enhances folding efficiency. Bioinformatic analysis showed that in C. elegans there are two open reading frames (F48E3.3 and F26H9.8 to be referred as uggt-1 and uggt-2, respectively) coding for UGGT homologues. Expression of both genes in Schizosaccharomyces pombe mutants devoid of UGGT activity showed that uggt-1 codes for an active UGGT protein (CeUGGT-1). On the other hand, uggt-2 coded for a protein (CeUGGT-2) apparently not displaying a canonical UGGT activity. This protein was essential for viability, although cnx/crt null worms were viable. We constructed transgenic worms carrying the uggt-1 promoter linked to the green fluorescent protein (GFP) coding sequence and found that CeUGGT-1 is expressed in cells of the nervous system. uggt-1 is upregulated under ER stress through the ire-1 arm of the unfolded protein response (UPR). Real-time PCR analysis showed that both uggt-1 and uggt-2 genes are expressed during the entire C. elegans life cycle. RNAi-mediated depletion of CeUGGT-1 but not of CeUGGT-2 resulted in a reduced lifespan and that of CeUGGT-1 and CeUGGT-2 in a developmental delay. We found that both CeUGGT1 and CeUGGT2 play a protective role under ER stress conditions, since 10 µg/ml tunicamycin arrested development at the L2/L3 stage of both uggt-1(RNAi) and uggt-2(RNAi) but not of control worms. Furthermore, we found that the role of CeUGGT-2 but not CeUGGT-1 is significant in relieving low ER stress levels in the absence of the ire-1 unfolding protein response signaling pathway. Our results indicate that both C. elegans UGGT homologues have distinct biological functions

Initial activation of EpCAM cleavage via cell-to-cell contact

<p>Abstract</p> <p>Background</p> <p>Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein, which is frequently over-expressed in simple epithelia, progenitors, embryonic and tissue stem cells, carcinoma and cancer-initiating cells. Besides functioning as a homophilic adhesion protein, EpCAM is an oncogenic receptor that requires regulated intramembrane proteolysis for activation of its signal transduction capacity. Upon cleavage, the extracellular domain EpEX is released as a soluble ligand while the intracellular domain EpICD translocates into the cytoplasm and eventually into the nucleus in combination with four-and-a-half LIM domains protein 2 (FHL2) and β-catenin, and drives cell proliferation.</p> <p>Methods</p> <p>EpCAM cleavage, induction of the target genes, and transmission of proliferation signals were investigated under varying density conditions using confocal laser scanning microscopy, immunoblotting, cell counting, and conditional cell systems.</p> <p>Results</p> <p>EpCAM cleavage, induction of the target genes, and transmission of proliferation signals were dependent on adequate cell-to-cell contact. If cell-to-cell contact was prohibited EpCAM did not provide growth advantages. If cells were allowed to undergo contact to each other, EpCAM transmitted proliferation signals based on signal transduction-related cleavage processes. Accordingly, the pre-cleaved version EpICD was not dependent on cell-to-cell contact in order to induce <it>c-myc </it>and cell proliferation, but necessitated nuclear translocation. For the case of contact-inhibited cells, although cleavage of EpCAM occurred, nuclear translocation of EpICD was reduced, as were EpCAM effects.</p> <p>Conclusion</p> <p>Activation of EpCAM's cleavage and oncogenic capacity is dependent on cellular interaction (juxtacrine) to provide for initial signals of regulated intramembrane proteolysis, which then support signalling via soluble EpEX (paracrine).</p