14 research outputs found
Cardiac Assist Devices: Early Concepts, Current Technologies, and Future Innovations
Congestive heart failure (CHF) is a debilitating condition that afflicts tens of millions of people worldwide and is responsible for more deaths each year than all cancers combined. Because donor hearts for transplantation are in short supply, a safe and durable means of mechanical circulatory support could extend the lives and reduce the suffering of millions. But while the profusion of blood pumps available to clinicians in 2019 tend to work extremely well in the short term (hours to weeks/months), every long-term cardiac assist device on the market today is limited by the same two problems: infections caused by percutaneous drivelines and thrombotic events associated with the use of blood-contacting surfaces. A fundamental change in device design is needed to address both these problems and ultimately make a device that can support the heart indefinitely. Toward that end, several groups are currently developing devices without blood-contacting surfaces and/or extracorporeal power sources with the aim of providing a safe, tether-free means to support the failing heart over extended periods of time
Linear muscle power for cardiac support: current progress and future direction
The use of electrically-stimulated skeletal muscle as an endogenous power source is an attractive approach to long-term cardiac assistance. The principle advantage of this technique over current methods is that it obviates the need for extracorporeal power sources and provides a reliable, low-cost, self-sustaining source of energy without immune compromise or loss of patient autonomy. This article briefly examines the various approaches to harnessing muscle power, details the rationale for the use of muscle in a linear configuration, and reviews our progress to date regarding development of a ventricular assist device powered by in situ skeletal muscle. Key words: skeletal muscle, cardiac assist, electrical stimulation, conditioning, linear contraction, prosthesis, latissimus dorsi. Basic Appl. Myol. 9 (4): 175-186, 1999 Cardiovascular disease is the leading killer in the United States, claiming more than 954,000 lives annually. Despite intense efforts to prevent and treat thes
Left ventricular simulation of cardiac compression: Hemodynamics and regional mechanics.
Heart failure is a global epidemic. Left ventricular assist devices provide added cardiac output for severe cases but cause infection and thromboembolism. Proposed direct cardiac compression devices eliminate blood contacting surfaces, but no group has optimized the balance between hemodynamic benefit and excessive ventricular wall strains and stresses. Here, we use left ventricular simulations to apply compressions and analyze hemodynamics as well as regional wall mechanics. This axisymmetric model corresponds with current symmetric bench prototypes. At nominal pressures of 3.1 kPa applied over the epicardial compression zone, hemodynamics improved substantially. Ejection fraction changed from 17.6% at baseline to 30.3% with compression and stroke work nearly doubled. Parametric studies were conducted by increasing and decreasing applied pressures; ejection fraction, peak pressure, and stroke work increased linearly with changes in applied compression. End-systolic volume decreased substantially. Regional mechanics analysis showed principal stress increases at the endocardium, in the middle of the compression region. Principal strains remained unchanged or increased moderately with nominal compression. However, at maximum applied compression, stresses and strains increased substantially providing potential constraints on allowable compressions. These results demonstrate a framework for analysis and optimization of cardiac compression as a prelude to biventricular simulations and subsequent animal experiments
Ventricle-specific epicardial pressures as a means to optimize direct cardiac compression for circulatory support: A pilot study.
Direct cardiac compression (DCC) holds enormous potential as a safe and effective means to treat heart failure patients who require long-term, or even permanent, biventricular support. However, devices developed to date are not tuned to meet the individual compression requirements of the left and right ventricles, which can differ substantially. In this paper, a systematic study examining the relationship, range, and effect of independent pressures on the left and right epicardial surfaces of a passive human heart model was performed as a means to optimize cardiac output via DCC support. Hemodynamic and tissue deformation effects produced by varying epicardial compressions were examined using finite element analysis. Results indicate that 1) designing a direct cardiac compression pump that applies separate pressures to the left and right ventricles is critical to maintain equivalent stroke volume for both ventricles, and 2) left and right ventricular epicardial pressures of 340 mmHg and 44 mmHg, respectively, are required to induce normal ejection fractions in a passive heart. This pilot study provides fundamental insights and guidance towards the design of improved direct cardiac compression devices for long-term circulatory support
A femoral artery cannula that allows distal blood flow
ObjectiveA femoral artery cannula is used for certain types of circulatory support but can cause ischemia, especially during prolonged perfusion. This study tests the function of a femoral cannula designed to allow proximal and distal blood flow.MethodsFive pigs were used in the study. In each animal a distal-flow cannula was implanted in the femoral artery of one leg, and the same-sized standard cannula was implanted in the other. Blood was drained from the left atrium and delivered to the femoral artery through the distal-flow cannula or standard cannula by using a centrifugal pump. An ultrasonic flow probe and microspheres were used to quantify flow and perfusion distal to the cannula.ResultsDistal femoral flow and tissue perfusion were present in all animals (5/5) with the distal-flow cannula but only in 1 of 5 animals with the standard cannula (P < .048). Distal flow did not change with pump flow. Mean distal flow at each level of pump flow was higher with the distal-flow cannula (P < .05). Tissue perfusion was also higher with the distal-flow cannula (0.052 ± 0.028 vs 0.010 ± 0.022 mL·min−1·g−1, P < .03).ConclusionsIn the swine model the distal-flow cannula allowed greater and more consistent distal flow than the standard cannula. The use of a distal-flow cannula for circulatory support might reduce the risk of distal limb ischemia