82 research outputs found
FROM ARCHIVE DOCUMENTATION TO ONLINE 3D MODEL VISUALIZATION OF NO LONGER EXISTING STRUCTURES: THE TURIN 1911 PROJECT
Rebuilding the past of cultural heritage through digitization, archiving and visualization by means of digital technology is becoming an emerging issue to ensure the transmission of physical and digital documentation to future generations as evidence of culture, but also to enable present generation to enlarge, facilitate and cross relate data and information in new ways. In this global effort, the digital 3D documentation of no longer existing cultural heritage can be essential for the understanding of past events and nowadays, various digital techniques and tools are developing for multiple purposes.
In the present research the entire workflow, starting from archive documentation collection and digitization to the 3D models metrically controlled creation and online sharing, is considered. The technical issues to obtain a detail 3D model are examined stressing limits and potentiality of 3D reconstruction of disappeared heritage and its visualization exploiting three complexes belonging to 1911 Turin Worldâs Fair
"TORINO 1911" project: A contribution of a SLAM-based survey to extensive 3D heritage modeling
In the framework of the digital documentation of complex environments the advanced Geomatics researches offers integrated solution and multi-sensor strategies for the 3D accurate reconstruction of stratified structures and articulated volumes in the heritage domain. The use of handheld devices for rapid mapping, both image- and range-based, can help the production of suitable easy-to use and easy-navigable 3D model for documentation projects. These types of reality-based modelling could support, with their tailored integrated geometric and radiometric aspects, valorisation and communication projects including virtual reconstructions, interactive navigation settings, immersive reality for dissemination purposes and evoking past places and atmospheres. The aim of this research is localized within the âTorino 1911â project, led by the University of San Diego (California) in cooperation with the PoliTo. The entire project is conceived for multi-scale reconstruction of the real and no longer existing structures in the whole park space of more than 400,000 m<sup>2</sup>, for a virtual and immersive visualization of the Turin 1911 International âFabulous Expositionâ event, settled in the Valentino Park. Particularly, in the presented research, a 3D metric documentation workflow is proposed and validated in order to integrate the potentialities of LiDAR mapping by handheld SLAM-based device, the ZEB REVO Real Time instrument by GeoSLAM (2017 release), instead of TLS consolidated systems. Starting from these kind of models, the crucial aspects of the trajectories performances in the 3D reconstruction and the radiometric content from imaging approaches are considered, specifically by means of compared use of common DSLR cameras and portable sensors
3D WEBGIS APPLICATIONS FOR DIGITAL HUMANITIES STUDIES: THE TURIN 1911 PROJECT
Documentation of CH is paramount to preserve its memory and allow its study, especially when CH is meant to be dismantled, as for the architectures of Worldâs Fairs. Very few efforts are undertaken to achieve this goal and national and international institutions rarely adopt innovative digital technologies. Digital technologies and products like 3D digital models are successfully and largely applied in CH domains, while webGIS is less explored for CH. Nevertheless, 3D digital models are rarely adopted to accompany digital archives and Digital Humanities studies. Very few cases use 3D models for Worldâs Fairsâ study and documentation. WebGIS is not used for Worldâs Fairs, and are scarcely adopted and not fully exploited by Digital Humanities and digital archives for sharing data and information about CH. Turin 1911 is the first digital project aimed to virtually document, recreate, and study an entire Worldâs Fair. Combining digital technologies (geo-DB, 3D digital reconstruction, and 3D webGIS) with cataloging standards, Turin 1911 is a pioneering initiative that applies these innovations to Digital Humanities in order to share information online. In this paper, dedicated webGIS applications are developed for the Turin 1911 needs, reporting the designed procedure, challenges in the development phase, and potentialities for Digital Humanities research. Finally, BIM models are also integrated in webGIS apps, making visible no more visible architectures. The paper discusses how webGIS apps could become a way for sharing information and data, but also a working environment for Digital Humanities studies where the research takes place in 3D environments
Reação da cultivar Navelina ISA 315 (Citrus sinensis L. Osb.), à clorose variegada dos citros em condiçÔes de campo.
A clorose variegada dos citros (CVC), causada pela bactĂ©ria Xylella fastidiosa, estĂĄ presente no Estado de SĂŁo Paulo desde 1987. Todas as variedades comerciais de laranjas doces sĂŁo afetadas. Causa redução da produção, principalmente pela acentuada redução no tamanho dos frutos. (LARANJEIRA et al., 2005). A CVC Ă© transmitida por meio de borbulhas contaminadas e por cigarrinhas das famĂlias Cicadellidae, em citros existem diversas espĂ©cies transmissoras de X. fastidiosa, porĂ©m a eficiĂȘncia na transmissĂŁo Ă© inferior a 15%, e este Ăndice pode variar entre espĂ©cies em função de mecanismos fisiolĂłgicos e comportamentais (YAMAMOTO, 2007; LOPES, 1996). Os sintomas caracterĂsticos da doença sĂŁo cloroses internervais amareladas na face superior da folha com correspondente necroses de tons de marrom na face inferior, a frutificação tem tendĂȘncia de ser em pencas onde os frutos tornam-se rĂgidos, pequenos e com uma concentração de açĂșcar maior que o normal (LARANJEIRA et al., 2005).pdf 12
Patients with definite and inconclusive evidence of reflux according to Lyon consensus display similar motility and esophagogastric junction characteristics
Background/Aims: The role of esophageal high-resolution manometry (HRM) within Lyon consensus phenotypes, especially patients with inconclusive gastroesophageal reflux disease (GERD) evidence, has not been fully investigated. In this multicenter, observational study we aim to compare HRM parameters in patients with GERD stratified according to the Lyon consensus.
Methods: Clinical and endoscopic data, HRM and multichannel intraluminal impedance-pH (MII-pH) studies performed off proton pump inhibitor therapy in patients with esophageal GERD symptoms were reviewed. Lyon consensus criteria identified pathological GERD, reflux hypersensitivity, functional heartburn, and inconclusive GERD. Patients, with inconclusive GERD were further subdivided into 2 groups based on total reflux numbers (†80 or \u3e 80 reflux episodes) during the MII-pH recording time.
Results: A total of 264 patients formed the study cohort. Pathological GERD and inconclusive GERD patients were associated with higher numbers of reflux episodes, lower mean nocturnal baseline impedance (MNBI) values, and a higher proportion of patients with pathologic MNBI compared to functional heartburn (
Conclusion: Esophageal motor parameters on HRM are similar between pathologic and inconclusive GERD according to the Lyon consensus
Immunoexpression Of α2-integrin And Hsp47 In Hereditary Gingival Fibromatosis And Gingival Fibromatosis-associated Dental Abnormalities
Objective: The purpose of the present study was to investigate the expression of the α2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingiva (NG). Study Design: Immunohistochemistry was performed with antibodies against α2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. Results: Immunoreactivity for α2-integrin and Hsp47 was observed in the nucleus of epithelial cells of both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (pâ€0.05). Despite the markup α2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (pâ„0.05). Conclusions: Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in α2-integrin expression was observed between GF and NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis. © Medicina Oral S. L. C.I.F. 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Report of an extensive four-generation pedigree (1994) Oral Surg Oral Med Oral Pathol, 78, pp. 452-454Martelli-JĂșnior, H., Lemos, D.P., Silva, C.O., Graner, E., Coletta, R.D., Hereditary gingival fibromatosis: Report of a five-generation family using cellular proliferation analysis (2005) J Periodontol, 76, pp. 2299-2305Vigneswaran, N., Zhao, W., Dassanayake, A., Muller, S., Miller, D.M., Zacharias, W., Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer (2000) Hum Pathol, 31, pp. 931-937Zhou, J., Meng, L.Y., Ye, X.Q., von der Hoff, J.W., Bian, Z., Increased expression of integrin alpha 2 and abnormal response to TGF-ÎČ1 in hereditary gingival fibromatosis (2009) Oral Dis, 15, pp. 414-421Nagata, K., Hosokawa, N., Regulation and function of collagen-specific molecular chaperone, HSP47 (1996) Cell Struct Funct, 21, pp. 425-430Bolcato-Bellemin, A.-L., Elkaim, R., Tenenbaum, H., Expression of RNAs encoding for α and ÎČ integrin subunits in periodontitis and in cyclosporin A gingival overgrowth (2003) J Clin Periodontol, 30, pp. 937-943Kataoka, M., Seto, H., Wada, C., Kido, J., Nagata, T., Decreased expression of α2 integrin in fibroblasts isolated from cyclosporin A-induced gingival overgrowth in rats (2003) J Periodontal Res, 38, pp. 533-537Slambrouk, S.V., Jenkins, A.R., Romero, A.E., Steelant, W.F.A., Reorganization of the integrin α2 subunit controls cell adhesion and cancer cell invasion in prostate cancer (2009) Int J Oncol, 34, pp. 1717-1726O'Sullivan, J., Bitu, C.C., Daly, S.B., Urquhart, J.E., Barron, M.J., Bhaskar, S.S., Whole-exome sequencing identifies FAM20A mutations as a cause of amelogenesis imperfect and gingival hyperplasia syndrome (2011) Am J Hum Genet, 88, pp. 616-620Martelli-JĂșnior, H., Santos, C.O., Bonan, P.R., Moura, P.F., Bitu, C.C., LeĂłn, J.E., Minichromosome maintenance 2 and 5 expression is increased in the epithelium of hereditary gingival fibromatosis associated with dental abnormalities (2011) Clinics, 66, pp. 753-757Shiuan-Shinn, L., Ling-Hsien, T., Yi-Ching, L., Chung-Hung, T., Yu-Chao, C., Heat shock protein 47 in oral squamous cell carcinomas and upregulated by arecoline in human oral ephitelial cells (2011) J Oral Pathol Med, 40, pp. 390-396Tagushi, T., Nazneen, A., Al-Shihri, A.A., Turkistani, K.A., Razzaque, M.S., Heat shock protein 47: A novel biomarker of phenotypically altered collagen-producing cells (2011) Acta Histochem Cytochem, 44, pp. 35-41Totan, S., Echo, A., Yuksel, E., Heat shock proteins modulate keloid formation (2011) Eplasty, 11, pp. 190-20
Huanglongbing (ex-greening) dos citros: desenvolvendo abordagens biotecnolĂłgicas de manejo
O huanglongbing (HLB, ex-greening) dos citros Ă© considerado a principal doença da cultura em todo o mundo e tem causado prejuĂzos significativos ao Brasil. O controle da doença tem sido realizado atravĂ©s da erradicação de plantas sintomĂĄticas e aplicação de inseticidas, mas hĂĄ uma grande demanda por estratĂ©gias alternativas, menos onerosas e menos danosas ao ambiente.O projeto propĂ”e, como estratĂ©gia de manejo a curto prazo, uma nova abordagem de controle do vetor, utilizando-se estirpes de Bacillus thuringiensis. PropĂ”e tambĂ©m abordagens de mĂ©dio e longo prazos, como genoma funcional de laranja infectada, transformação genĂ©tica e genoma completo de citros dentro do ConsĂłrcio Internacional (ICCG). Para tanto, agregarĂĄ ferramentas de biotecnologia, principalmente a partir do CitEST, base de dados de genoma expresso de citros.O projeto claramente demonstra seu carĂĄter multi e interdisciplinar, que tem como objetivo principal, alĂ©m de buscar alternativas de controle biolĂłgico do psilĂdeo, ampliar e aprimorar o conhecimento sobre o genoma dos citros e as interaçÔes planta-patĂłgen
Risk of leukemia in first degree relatives of patients with nonsyndromic cleft lip and palate
Activation of the Canonical Wnt/ÎČ-Catenin Pathway in ATF3-Induced Mammary Tumors
Female transgenic mice that constitutively overexpress the transcription factor ATF3 in the basal epithelium of the mammary gland develop mammary carcinomas with high frequency, but only if allowed to mate and raise pups early in life. This transgenic mouse model system reproduces some features of human breast cancer in that about 20% of human breast tumor specimens exhibit overexpression of ATF3 in the tumor cells. The ATF3-induced mouse tumors are phenotypically similar to mammary tumors induced by overexpression of activating Wnt/ÎČ-catenin pathway genes. We now show that the Wnt/ÎČ-catenin pathway is indeed activated in ATF3-induced tumors. ÎČ-catenin is transcriptionally up-regulated in the tumors, and high levels of nuclear ÎČ-catenin are seen in tumor cells. A reporter gene for Wnt/ÎČ-catenin pathway activity, TOPGAL, is up-regulated in the tumors and several downstream targets of Wnt signaling, including Ccnd1, Jun, Axin2 and Dkk4, are also expressed at higher levels in ATF3-induced tumors compared to mammary glands of transgenic females. Several positive-acting ligands for this pathway, including Wnt3, Wnt3a, Wnt7b, and Wnt5a, are significantly overexpressed in tumor tissue, and mRNA for Wnt3 is about 5-fold more abundant in transgenic mammary tissue than in non-transgenic mammary tissue. Two known transcriptional targets of ATF3, Snai1 and Snai2, are also overexpressed in the tumors, and Snail and Slug proteins are found to be located primarily in the nuclei of tumor cells. In vitro knockdown of Atf3 expression results in significant decreases in expression of Wnt7b, Tcf7, Snai2 and Jun, suggesting that these genes may be direct transcriptional targets of ATF3 protein. By chromatin immunoprecipitation analysis, both ATF3 and JUN proteins appear to bind to a particular subclass of AP-1 sites upstream of the transcriptional start sites of each of these genes
Production and characterization of monoclonal antibodies anti fragment Fc of bovine IgG
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