5,836 research outputs found
Sequence sensitivity of breathing dynamics in heteropolymer DNA
We study the fluctuation dynamics of localized denaturation bubbles in
heteropolymer DNA with a master equation and complementary stochastic
simulation based on novel DNA stability data. A significant dependence of
opening probability and waiting time between bubble events on the local DNA
sequence is revealed and quantified for a biological sequence of the T7
bacteriophage. Quantitative agreement with data from fluorescence correlation
spectroscopy (FCS) is demonstrated.Comment: 4 pages, 5 figures, to appear in Physical Review Letter
Bubbles, clusters and denaturation in genomic DNA: modeling, parametrization, efficient computation
The paper uses mesoscopic, non-linear lattice dynamics based
(Peyrard-Bishop-Dauxois, PBD) modeling to describe thermal properties of DNA
below and near the denaturation temperature. Computationally efficient notation
is introduced for the relevant statistical mechanics. Computed melting profiles
of long and short heterogeneous sequences are presented, using a recently
introduced reparametrization of the PBD model, and critically discussed. The
statistics of extended open bubbles and bound clusters is formulated and
results are presented for selected examples.Comment: to appear in a special issue of the Journal of Nonlinear Mathematical
Physics (ed. G. Gaeta
New Constraints on Dispersive Form Factor Parameterizations from the Timelike Region
We generalize a recent model-independent form factor parameterization derived
from rigorous dispersion relations to include constraints from data in the
timelike region. These constraints dictate the convergence properties of the
parameterization and appear as sum rules on the parameters. We further develop
a new parameterization that takes into account finiteness and asymptotic
conditions on the form factor, and use it to fit to the elastic \pi
electromagnetic form factor. We find that the existing world sample of timelike
data gives only loose bounds on the form factor in the spacelike region, but
explain how the acquisition of additional timelike data or fits to other form
factors are expected to give much better results. The same parameterization is
seen to fit spacelike data extremely well.Comment: 24 pages, latex (revtex), 3 eps figure
Form factors of pion and kaon
An addtional intrinsic form factors of pion and kaons have been studied.Comment: 14 pages and 10 figure
Kinetic-scale magnetic turbulence and finite Larmor radius effects at Mercury
We use a nonstationary generalization of the higher-order structure function
technique to investigate statistical properties of the magnetic field
fluctuations recorded by MESSENGER spacecraft during its first flyby
(01/14/2008) through the near Mercury's space environment, with the emphasis on
key boundary regions participating in the solar wind -- magnetosphere
interaction. Our analysis shows, for the first time, that kinetic-scale
fluctuations play a significant role in the Mercury's magnetosphere up to the
largest resolvable time scale ~20 s imposed by the signal nonstationarity,
suggesting that turbulence at this planet is largely controlled by finite
Larmor radius effects. In particular, we report the presence of a highly
turbulent and extended foreshock system filled with packets of ULF
oscillations, broad-band intermittent fluctuations in the magnetosheath,
ion-kinetic turbulence in the central plasma sheet of Mercury's magnetotail,
and kinetic-scale fluctuations in the inner current sheet encountered at the
outbound (dawn-side) magnetopause. Overall, our measurements indicate that the
Hermean magnetosphere, as well as the surrounding region, are strongly affected
by non-MHD effects introduced by finite sizes of cyclotron orbits of the
constituting ion species. Physical mechanisms of these effects and their
potentially critical impact on the structure and dynamics of Mercury's magnetic
field remain to be understood.Comment: 46 pages, 5 figures, 2 table
Pion and Kaon Vector Form Factors
We develop a unitarity approach to consider the final state interaction
corrections to the tree level graphs calculated from Chiral Perturbation Theory
() allowing the inclusion of explicit resonance fields. The method is
discussed considering the coupled channel pion and kaon vector form factors.
These form factors are then matched with the one loop results. A very
good description of experimental data is accomplished for the vector form
factors and for the P-wave phase shifts up to
GeV, beyond which multiparticle states play a non negligible role. In
particular the low and resonance energy regions are discussed in detail and for
the former a comparison with one and two loop is made showing a
remarkable coincidence with the two loop results.Comment: 20 pages, 7 figs, to appear in Phys. Rev.
Smoking influences outcome in patients who had thrombolysed ischaemic stroke: The ENCHANTED study
Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke (AIS), we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED). Methods Post-hoc analyses of ENCHANTED, an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS. Multivariable logistic regression models with inverse probability of treatment weighting (IPTW) propensity scores were used to determine associations of self-reported smoking status and clinical outcomes, according to 90-day modified Rankin Scale (mRS) scores and symptomatic intracerebral haemorrhage (sICH). Results Of 4540 patients who had an AIS, there were 1008 (22.2%) current smokers who were younger and predominantly male, with more comorbidities of hypertension, coronary artery disease, atrial fibrillation and diabetes mellitus, and greater baseline neurological impairment, compared with non-smokers. In univariate analysis, current smokers had a higher likelihood of a favourable shift in mRS scores (OR 0.88, 95% CI 0.77 to 0.99; p=0.038) but this association reversed in a fully adjusted model with IPTW (adjusted OR 1.15, 95% CI 1.04 to 1.28; p=0.009). A similar trend was also apparent for dichotomised poor outcome (mRS scores 2-6: OR 1.18, 95% CI 1.05 to 1.33; p=0.007), but not with the risk of sICH across standard criteria. Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS. Trial registration number NCT01422616
Level of sedation in critically ill adult patients : a protocol for a systematic review with meta-analysis and trial sequential analysis
Publisher Copyright: © 2022 BMJ Publishing Group. All rights reserved.Introduction It is standard of care to provide sedation to critically ill patients to reduce anxiety, discomfort and promote tolerance of mechanical ventilation. Given that sedatives can have differing effects based on a variety of patient and pharmacological characteristics, treatment approaches are largely based on targeting the level of sedation. The benefits of differing levels of sedation must be balanced against potential adverse effects including haemodynamic instability, causing delirium, delaying awakening and prolonging the time of mechanical ventilation and intensive care stay. This systematic review with meta-analysis aims to investigate the current evidence and compare the effects of differing sedation levels in adult critically ill patients. Methods and analyses We will conduct a systematic review based on searches of preidentified major medical databases (eg, MEDLINE, EMBASE, CENTRAL) and clinical trial registries from their inception onwards to identify trials meeting inclusion criteria. We will include randomised clinical trials comparing any degree of sedation with no sedation and lighter sedation with deeper sedation for critically ill patients admitted to the intensive care unit. We will include aggregate data meta-analyses and trial sequential analyses. Risk of bias will be assessed with domains based on the Cochrane risk of bias tool. An eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed using Grades of Recommendations, Assessment, Development and Evaluation. Ethics and dissemination No formal approval or review of ethics is required as individual patient data will not be included. This systematic review has the potential to highlight (1) whether one should believe sedation to be beneficial, harmful or neither in critically ill adults; (2) the existing knowledge gaps and (3) whether the recommendations from guidelines and daily clinical practice are supported by current evidence. These results will be disseminated through publication in a peer-reviewed journal.Peer reviewe
Evidence for Factorization in Three-body B --> D(*) K- K0 Decays
Motivated by recent experimental results, we use a factorization approach to
study the three-body B --> D(*) K- K0 decay modes. Two mechanisms are proposed
for kaon pair production: current-produced (from vacuum) and transition (from B
meson). The Bbar0 --> D(*)+ K- K0 decay is governed solely by the
current-produced mechanism. As the kaon pair can be produced only by the vector
current, the matrix element can be extracted from e+ e- --> K Kbar processes
via isospin relations. The decay rates obtained this way are in good agreement
with experiment. Both current-produced and transition processes contribute to
B- --> D(*)0 K- K0 decays. By using QCD counting rules and the measured B- -->
D(*)0 K- K0 decay rates, the measured decay spectra can be understood.Comment: 17 pages, 6 figure
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