Reproductive Performance Of Pregnant Rats And Embryotoxic Effects Of Ciprofloxacin

To observe the effect of ciprofloxacin on both pregnancy and physical development of fetuses, the drug was orally administered to thirty pregnant rats at doses of 20 and 40 mg/kg body weight from day-1 to day-19 of gestation. The intact rat fetuses were isolated on day-19 of gestation. Ciprofloxacin induced general changes in the reproductive performance of female rats and significant alterations in the development of the skeletal parameters of fetuses.6117980Barrow, M.V., Taylor, W.J., A rapid method for detecting malformations in rat fetuses (1967) J Morphol, 127, pp. 291-306Berkovitch, M., Pastuszak, A., Gazarian, M., Lewis, M., Koren, G., Safety of the new quinolones in pregnancy (1994) Obstet Gynecol, 84, pp. 535-538Danisovicova, A., Brezina, M., Belan, S., Kayserova, H., Kaiserova, E., Hruskovic, I., Orosova, K., Matheova, E., Magnetic resonance imaging in children receiving quinolones: No evidence of quinolone-induced arthropathy. A multicenter survey (1994) Chemotherapy, 40, pp. 209-214Dawson, A.B., Note on the staining of skeleton of cleared skeletal specimens with alizarin red S (1926) Stain Technol, 1, pp. 123-124Del Fiol, F., Gerenutti, M., Groppo, F.C., Antibiotics and pregnancy (2005) Pharmazie, 60, pp. 483-493Gerenutti, M., De-Souza Spinosa, H., Bernard, M.M., Algumas Considerações sobre a toxicologia do desenvolvimento (1991) Com. Cient. da Fac. Méd. Vet. e Zoot. da Universidade de São Paulo, 1, pp. 27-29Grady, R., Safety profile of quinolone antibiotics in the pediatric population (2003) Pediatr Meet Dis J, 22, pp. 1128-1132Hooton, T.M., Stamm, W.E., Diagnosis and treatment of uncomplicated urinary tract infection (1997) Infect Dis Clin North Am, 11, pp. 551-581Lemonica, I.P., Damascene, D.C., Di-Stasi, L.C., Study of the embryo-toxic effects of an extract of rosemary (Rosmarinus officinalis L.) (1996) Braz J Med Biol Res, 29, pp. 223-227Loebstein, R., Addis, A., Ho, E., Andreou, R., Sage, S., Donnenfeld, A.E., Schick, B., Koren, G., Pregnancy outcome following gestational exposure to fluoroquinolones: A multicenter prospective controlled study (1998) Antimicrob Agents Chemother, 42, pp. 1336-1339Nagai, A., Miyazaki, M., Morita, T., Furubo, S., Kizawa, K., Fukumoto, H., Sanzen, T., Kawamura, Y., Comparative articular toxicity of garenoxacin, a novel quinolone antimicrobial agent, in juvenile beagle dogs (2002) J Toxicol Sci, 27, pp. 219-228Saravanos, K., Duff, P., The quinolone antibiotics (1992) Obstet Gynecol Clin North Am, 19, pp. 529-537Sterz, H., Lehmann, H., A critical comparison of the freehand razor-blade dessection method according to Wilson with an in-situ sectioning method for the rat fetuses (1985) Teratog Carcinog Mutagen, 5, pp. 347-354Vickery, B.H., Bennett, J.P., Rats and mice (1970) Reproduction and Beeding Techniques for Laboratory Animals, pp. 299-315. , Hafez ESE (ed). Philadelphia: Lea and FebigerYabe, K., Yoshida, K., Yamamoto, N., Nishida, S., Ohshima, C., Sekiguchi, M., Yamada, K., Furuhama, K., Diagnosis of quinolone-induced arthropathy in juvenile dogs by use of magnetic resonance (MR) imaging (1997) J Vet Med Sci, 59, pp. 597-59