2 research outputs found

    SAPHO syndrome the therapeutical challenge

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    Introduction: Sapho syndrome is a syndrome characterizing with osteoarticular end dermatologic symptoms. Acronym 'SAPHO' means: S-Sinovitis, A-Acne, H-Hyperostosis, O-Osteytis. SAPHO syndrome has a 50 different names in existing literature. For now, etiology remains unclear, but it belongs to group of seronegative spondylarthropathies. Therapy of SAPHO includes NSAIL, glucocorticosteroids, disease modifying anthireumatic drugs (DMARD), antibiotics, bifosfonatos, and anti TNF - alfa drugs with variable success. Case outline: Patient P.Z, 47 age, female, comes in the hospital, because of pain in anterior chest, with propagation in right arm, end morning stiffness in sacral part, which passes short after. Also, with recidivant pustules on the palms, bilaterally, which precedes itch. Bone scintigraphy was performed: There is a clear increasing binding of radiopharmacs in projection of strenoclavicular joint, and slightly in both shoulders and both knees. HP: Pustulosis palmoplantaris. We introduced in therapy azithromycin in the dose of 500 mg, two times weekly, for 16 weeks. Patient, one year after, is without relapses of arthritis and skin lesions. Conclusion: This report has goal, to get more knowledge about this rare disease, and to be easier for recognition. Also we want to introduce other physicians, of varying specialities, like orthopaedics, and other surgeries, with this disease, not only rheumatologists, dermatologists, and pediatrics

    Arthritis follows an acute urogenital or intestinal: Reiters disease

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    Arthritis following dyzentery or urethritis was mentioned before our era and later by many others. In 1818 Benjamin Brodie described 5 patients with typical 'Reiters disease': urethritis, conjunctivitis, arthritis. Many diagnostic criteria for Reiters disease / reactive arthritis have been proposed for practical purpose the most acceeptable is the folowing one: posturethritic or postenterocolitic arthritis is Reiters disease / reactive arthritis. The findings of Chlamydiy from the synovia or in the synovial fluid of itients with RD suggest that arthritis may be of infective but not of reactive origin
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