261 research outputs found

    Multi-decadal modulations in the Aleutian-Icelandic Low seesaw and the axial symmetry of the Arctic Oscillation signature, as revealed in the 20th century reanalysis

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    Seesaw relationship in intensity between the surface Aleutian and Icelandic Lows (AIS) is a manifestation of atmospheric teleconnection that bridges the interannual variability over the Pacific and Atlantic in particular winter months. Analysis of the 20th Century Reanalysis data reveals that the strength and timing of AIS have undergone multi-decadal modulations in conjunction with those in structure of the Arctic Oscillation (AO) signature, extracted in the leading mode of interannual sea-level pressure (SLP) variability over the extratropical Northern Hemisphere. Specifically, events of what may be called ‘pure AO’, in which SLP anomalies exhibit a high degree of axial symmetry in association with in-phase SLP variability between the midlatitude Atlantic and Pacific, tended to occur during multi-decadal periods in which the inter-basin teleconnection through AIS was active under the enhanced interannual variability of the Aleutian Low. In contrast, the axial symmetry of the AO pattern was apparently reduced during a multi-decadal period in which the AIS teleconnection was inactive under the weakened interannual variability of the Aleutian Low. In this period, the leading mode of interannual SLP variability represented a meridional seesaw between the Atlantic and Arctic, which resembles SLP anomaly pattern associated with the cold-ocean/warm-land (COWL) temperature pattern. These multi-decadal modulations in interannual AIS signal and the axial symmetry of the interannual AO pattern occurred under multi-decadal changes in the background state that also represented the polarity changes of the COWL-like anomaly pattern

    Signaling through the TRAIL receptor DR5/FADD pathway plays a role in the apoptosis associated with skeletal myoblast differentiation

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    Apoptosis rather than differentiation is a physiological process during myogenesis and muscle regeneration. When cultured myoblasts were induced to differentiate, we detected an increase in caspase 8 activity. Pharmacological inhibition of caspase 8 activity decreased apoptosis. Expression of a dominant-negative mutant of the adapter protein FADD also abrogated apoptosis, implicating a death ligand pathway. Treatment with TRAIL, but not Fas, induced apoptosis in these myoblasts. Accordingly, treatment with a soluble TRAIL decoy receptor or expression of a dominant-negative mutant of the TRAIL receptor DR5 abrogated apoptosis. While TRAIL expression levels remained unaltered in apoptotic myoblasts, DR5 expression levels increased. Finally, we also detected a reduction in FLIP, a death-receptor effector protein and caspase 8 competitive inhibitor, to undetectable levels in apoptotic myoblasts. Thus, our data demonstrate an important role for the TRAIL/DR5/FADD/caspase 8 pathway in the apoptosis associated with skeletal myoblast differentiation. Identifying the functional apoptotic pathways in skeletal myoblasts may prove useful in minimizing the myoblast apoptosis that contributes pathologically to a variety of diseases and in minimizing the apoptosis of transplanted myoblasts to treat these and other disease states
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