Pengaruh Otonomi Daerah dan Manajemen Berbasis Sekolah terhadap Peningkatan Mutu Pendidikan Menengah Atas di Kab. Tangerang

The School Based Management Program (MBS) can assist in supporting the quality improvement of education in each region, so each region can empower participation and role of community in managing education. In order to find out significance of the impact of Regional Autonomy (OTDA) and MBS on Quality Improvement of Secondary High Education, then a research is made in Pangedagan SubDistrict. Methods used in the research are survey and quantitative method namely a method describing and analyzing a certain phenomenon or object researched and observed with correct interpretation. The use of this method is aimed to problem solving. Data collection technique uses questionnaire and literature research. Based on the performed research, the Impact of Regional Autonomy on Educational Quality Improvement is 0.582. The Impact of MBS on Educational Quality Improvement is 0.647 and the Impact of Regional Autonomy and MBS on Educational Quality Improvement is 0.706.Program manajemen Berbasis sekolah (mBs) dapat membantu dalam mendukung peningkatan mutu pendidikan ditiap daerah, sehingga masing-masing daerah dapat memberdayakan partisipasi serta peran masyarakat dalam mengelola pendidikan. Dalam rangka mengetahui sejauh mana pengaruh Otonomi Daerah dan mBs terhadap Peningkatan mutu Pendidikan menengah Atas maka di lakukan penelitian di wilayah Kecamatan Pagedangan. metode yang digunakan dalam penelitian ini adalah metode survey dan metode kuantitatif yaitu suatu metode yang didalamnya mendeskripsikan dan menganalisa suatu fenomena atau objek tertentu yang diteliti dan diamati dengan interpretasi yang tepat. Penggunaan metode ini tertuju pada pemecahan masalah. teknik pengumpulan data menggunakan angket dan penelitian kepustakaan. Berdasarkan hasil penelitian yang telah dilakukan, maka diperoleh hasil Pengaruh Otonomi Daerah terhadap Peniningkatan mutu Pendidikan adalah 0,582. Pengaruh mBs terhadap Peningkatan mutu Pendidikan adalah 0.647 dan Pengaruh Otonomi Daerah dan mBs terhadap Peningkatan mutu Pendidikan adalah 0,706

Dampak Pengganda Industri Pembibitan Gerakan Nasional Rehabilitasi Hutan dan Lahan

Salah satu upaya pemerintah mengatasi kerusakan hutan dan lahan kritis adalah melaksanakan program Gerakan Nasional Rehabilitasi Hutan dan Lahan (Gerhan). Secara keseluruhan dampak Gerhan diharapkan dapat menimbulkan Perubahan perilaku sosial masyarakat menuju terbangunnya kesadaran nasional untuk menanam pohon. Namun kecenderungan demikian tidak dapat diramalkan selama dampak sosial, dampak lingkungan dan dampak ekonominya tidak diketahui dengan pasti. Idealnya ketiga dampak tersebut perlu dikaji secara simultan. Namun penelitian ini lebih memfokuskan pada dampak ekonomi khususnya dampak pengganda industri pembibitan Gerhan, yang bertujuan untuk mengkaji dampak pengganda terkait dengan output, pendapatan dan tenaga kerja. Penelitian dilaksanakan di tiga desa contoh yang terlibat dalam program Gerhan: Desa Sirnajaya, Kabupaten Garut, Jawa Barat; Desa Margomulyo, Kabupaten Wonogiri, Jawa Tengah; dan Desa Golo, Kabupaten Bojonegoro, Jawa Timur. Dengan menggunakan model I-O, hasil penelitian menunjukkan bahwa dampak pengganda industri pembibitan Gerhan dalam perekonomian masing-masing desa contoh adalah kecil. Hal ini menyarankan bahwa kebijakan Gerhan perlu diperbaiki terutama terkait dengan pentingnya menggunakan sumberdaya lokal seperti pupuk kandang dan pembangunan benih sendiri di masing-masing desa yang akan melaksanakan Gerhan

Bennu regolith mobilized by TAGSAM: Expectations for the OSIRIS-REx sample collection event and application to understanding naturally ejected particles

The Origins, Spectral Interpretation, Resource Identification, and Security–Regolith Explorer (OSIRIS-REx) mission will collect material from the asteroid Bennu and return it to Earth. The sample collection method uses pressurized nitrogen gas to mobilize regolith. It is likely that the gas will mobilize more, potentially much more, material than is captured by the Touch-and-Go Sample Acquisition Mechanism (TAGSAM) for return. The amount, velocities, and fate of this mobilized material have important implications for our understanding of Bennu's physical properties and processes, such as impact cratering, regolith mobility, and the recently observed natural ejection of particles. The nature of the TAGSAM-ejected material is also significant for mission operations. We conducted numerical simulations and ground-based tests to estimate the amount and speeds of material mobilized by the sampling event. The estimated ejected masses range from 12 kg to >165 kg; given that Bennu appears to be a nearly strengthless rubble pile, the higher end of the mass range is more likely. Maximum ejection speeds for 1-cm-diameter particles could reach 10 m/s; smaller particles will be ejected at faster speeds. Minimum ejection speeds will be determined by the as yet unknown cohesive strength of Bennu's regolith. Material ejected more slowly than 10 cm/s will reaccrete on Bennu; material ejected between 10 and 30 cm/s may or may not reaccrete; and material ejected faster than 30 cm/s will escape. Some of the ejected material is predicted to remain in transient orbits around Bennu. The lifetimes of these orbits span from days to several weeks, the maximum duration of our integrations. Reaccreted material should be concentrated in a region near the sample site, although re-impacts will occur globally. Gas from TAGSAM will mobilize material beyond the contact perimeter; because of interactions between cohesion and microgravity, there is a preferred particle size of mobility, predicted to be tens of centimeters, depending on the TAG latitude. Observing Bennu during and after the sampling event will make it possible to test these predictions and understand how the asteroid responds to disruption and particle mobility across the surface

30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic – The GENEVA study

Background: Metabolic and bariatric surgery (MBS) is an effective treatment for adolescents with severe obesity. Objectives: This study examined the safety of MBS in adolescents during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a global, multicentre and observational cohort study of MBS performed between May 01, 2020, and October 10,2020, in 68 centres from 24 countries. Data collection included in-hospital and 30-day COVID-19 and surgery-specific morbidity/mortality. Results: One hundred and seventy adolescent patients (mean age: 17.75 ± 1.30 years), mostly females (n = 122, 71.8%), underwent MBS during the study period. The mean pre-operative weight and body mass index were 122.16 ± 15.92 kg and 43.7 ± 7.11 kg/m2, respectively. Although majority of patients had pre-operative testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 146; 85.9%), only 42.4% (n = 72) of the patients were asked to self-isolate pre-operatively. Two patients developed symptomatic SARS-CoV-2 infection post-operatively (1.2%). The overall complication rate was 5.3% (n = 9). There was no mortality in this cohort. Conclusions: MBS in adolescents with obesity is safe during the COVID-19 pandemic when performed within the context of local precautionary procedures (such as pre-operative testing). The 30-day morbidity rates were similar to those reported pre-pandemic. These data will help facilitate the safe re-introduction of MBS services for this group of patients

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts

Genomic insights into rapid speciation within the world's largest tree genus Syzygium

Acknowledgements Y.W.L. was supported by a postgraduate scholarship research grant from the Ministry of National Development, Singapore awarded through the National Parks Board, Singapore (NParks; NParks’ Garden City Fund). Principal research funding from NParks and the School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore, is acknowledged. We thank Peter Preiser, Associate Vice President for Biomedical and Life Sciences, for facilitating NTU support, and Kenneth Er, CEO of NParks, for facilitating research funding through that organisation. V.A.A. and C.L. were funded by SBS, NTU for a one-year research leave. V.A.A. and C.L. also acknowledge support from the United States National Science Foundation (grants 2030871 and 1854550, respectively). S.R. was supported by a postdoctoral research fellowship under the NTU Strategic Plant Programme. S.R. and N.R.W.C. acknowledge funding from NTU start-up and the Academy of Finland (decisions 318288, 319947) grants to J.S. Fieldwork conducted by Y.W.L. was supported by an Indonesian Government RISTEK research permit (Application ID: 1517217008) and an Access License from the Sabah State government [JKM/MBS.1000-2/2JLD.7(84)]. T.N.C.V. is grateful to the Assemblée de la Province Nord and Assemblée de la Province Sud (New Caledonia) for facilitating relevant collection permits. A.N. was partly supported by the Research Project Promotion Grant (Strategic Research Grant No. 17SP01302) from the University of the Ryukyus, and partly by the Environment Research and Technology Development Fund (JPMEERF20204003) from the Environmental Restoration and Conservation Agency of Japan. Fieldwork in Fiji conducted by R.B. was hosted and facilitated by Elina Nabubuniyaka-Young (The Pacific Community’s Centre for Pacific Crops and Trees, Fiji). We thank the NTU-Smithsonian Partnership for tree data obtained for the Bukit Timah Nature Reserve (BTNR) long-term forest dynamics plots. Administrative support provided by Mui Hwang Khoo-Woon and Peter Ang at the molecular laboratory of the Singapore Botanic Gardens (SBG) is acknowledged. Rosie Woods and Imalka Kahandawala (DNA and Tissue Bank, Royal Botanic Gardens, Kew) facilitated additional DNA samples. Daniel Thomas (SBG) and Yan Yu (Sichuan University) commented on biogeographical analyses. NovogeneAIT in Singapore is acknowledged for personalised sequencing service.Peer reviewedPublisher PD

Genomic insights into rapid speciation within the world's largest tree genus Syzygium

The relative importance of the mechanisms underlying species radiation remains unclear. Here, the authors combine reference genome assembly and population genetics analyses to show that neutral forces have contributed to the radiation of the most species-rich tree genus Syzygium. Species radiations, despite immense phenotypic variation, can be difficult to resolve phylogenetically when genetic change poorly matches the rapidity of diversification. Genomic potential furnished by palaeopolyploidy, and relative roles for adaptation, random drift and hybridisation in the apportionment of genetic variation, remain poorly understood factors. Here, we study these aspects in a model radiation, Syzygium, the most species-rich tree genus worldwide. Genomes of 182 distinct species and 58 unidentified taxa are compared against a chromosome-level reference genome of the sea apple, Syzygium grande. We show that while Syzygium shares an ancient genome doubling event with other Myrtales, little evidence exists for recent polyploidy events. Phylogenomics confirms that Syzygium originated in Australia-New Guinea and diversified in multiple migrations, eastward to the Pacific and westward to India and Africa, in bursts of speciation visible as poorly resolved branches on phylogenies. Furthermore, some sublineages demonstrate genomic clines that recapitulate cladogenetic events, suggesting that stepwise geographic speciation, a neutral process, has been important in Syzygium diversification.Peer reviewe

A Study of Strange Particle Production in Muon Neutrino Charged Current Interactions in the NOMAD Experiment

A study of strange particle production in muon neutrino charged current interactions has been performed using the data from the NOMAD experiment. Yields of neutral strange particles K0s, Lambda, AntiLambda have been measured. Mean multiplicities are reported as a function of the event kinematic variables Enu, W2 and Q2 as well as of the variables describing particle behaviour within a hadronic jet: xF, z and pT2. Decays of resonances and heavy hyperons with identified K0s and Lambda in the final state have been analyzed. Clear signals corresponding to K*+-, Sigma*+-, Xi- and Sigma0 have been observed.Comment: 43 pages, accepted for publication in the Nuclear Physics B as a Rapid Communication in Experimental High-Energy Physic

Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature

Truncating variants in exons 33 and 34 of the SNF2-related CREBBP activator protein (SRCAP) gene cause the neurodevelopmental disorder (NDD) Floating-Harbor syndrome (FLHS), characterized by short stature, speech delay, and facial dysmorphism. Here, we present a cohort of 33 individuals with clinical features distinct from FLHS and truncating (mostly de novo) SRCAP variants either proximal (n = 28) or distal (n = 5) to the FLHS locus. Detailed clinical characterization of the proximal SRCAP individuals identified shared characteristics: developmental delay with or without intellectual disability, behavioral and psychiatric problems, non-specific facial features, musculoskeletal issues, and hypotonia. Because FLHS is known to be associated with a unique set of DNA methylation (DNAm) changes in blood, a DNAm signature, we investigated whether there was a distinct signature associated with our affected individuals. A machine-learning model, based on the FLHS DNAm signature, negatively classified all our tested subjects. Comparing proximal variants with typically developing controls, we identified a DNAm signature distinct from the FLHS signature. Based on the DNAm and clinical data, we refer to the condition as "non-FLHS SRCAP-related NDD.'' All five distal variants classified negatively using the FLHS DNAm model while two classified positively using the proximal model. This suggests divergent pathogenicity of these variants, though clinically the distal group presented with NDD, similar to the proximal SRCAP group. In summary, for SRCAP, there is a clear relationship between variant location, DNAm profile, and clinical phenotype. These results highlight the power of combined epigenetic, molecular, and clinical studies to identify and characterize genotype-epigenotype-phenotype correlations.Genetics of disease, diagnosis and treatmen