Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review article, we report and discuss the three most relevant methodologies for extremely miniaturised implantable neurostimulator: ultrasound coupling, inductive coupling and capacitive coupling. For each powering method, the discussion starts describing the physical working principle. In particular, we focus on the challenges given by the miniaturisation of the implanted integrated circuits and the related ad-hoc solutions for wireless power transfer. Then, we present recent developments and progresses in wireless power transfer for biomedical applications. Last, we compare each technique based on key performance indicators to highlight the most relevant and innovative solutions suitable for neurostimulation, with the gaze turned towards miniaturisation

Procedimento per la generazione e l'analisi di segnali di elettrochemiluminescenza e relativo sistema

La presente invenzione si riferisce a un procedimento per la generazione e l‟analisi di segnali di elettrochemiluminescenza, che comprende le operazioni di generare uno stimolo in una cella elettrochimica comprendente un elettrodo di lavoro comprendente nanotubi di carbonio in contatto con una soluzione da misurare, cui è applicato detto stimolo, e rilevare e analizzare un segnale di elettrochemiluminescenza rappresentativo di radiazione di elettrochemiluminescenza emessa da detta soluzione in risposta a detto stimol

Long-Range Low-Power Soil Water Content Monitoring System for Precision Agriculture

World population growth and desertification are increasing the food demand. Food production must increase to ensure food security in the following years. Smart agriculture tries to improve food production thanks to the adoption of electronic sensors to monitor and control fruit and vegetable crops. Another critical point in agriculture is the use of potable water. Precision irrigation strategies can be implemented to reduce water waste and increase crop production. This paper proposes a long-range, low-power sensor node to monitor soil water content. It is possible to place multiple sensor nodes in the field and use the gathered data to determine the most suitable irrigation strategy. The node communicates thanks to the LoRa protocol and it can also be used in remote areas where it is impossible to have an internet connection

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Due to their well-defined plasmonic properties, gold nanorods (GNRs) can be fabricated with optimal light absorption in the near-infrared region of the electromagnetic spectrum, which make them suitable for cancer-related theranostic applications. However, their controversial safety profile, as a result of surfactant stabilization during synthesis, limits their clinical translation. We report a facile method to improve GNR biocompatibility through the presence of sodium dodecyl sulfate (SDS). GNRs (120 × 40 nm) were synthesized through a seed-mediated approach, using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant to direct the growth of nanorods and stabilize the particles. Post-synthesis, SDS was used as an exchange ligand to modify the net surface charge of the particles from positive to negative while maintaining rod stability in an aqueous environment. GNR cytotoxic effects, as well as the mechanisms of their cellular uptake, were examined in two different cancer cell lines, Lewis lung carcinoma (LLC) and HeLa cells. We not only found a significant dose-dependent effect of GNR treatment on cell viability but also a time-dependent effect of GNR surfactant charge on cytotoxicity over the two cell lines. Our results promote a better understanding of how we can mediate the undesired consequences of GNR synthesis byproducts when exposed to a living organism, which so far has limited GNR use in cancer theranostics

In-vivo monitoring for electrical expression of plant living parameters by an impedance lab system

We present a complete in-lab system to monitor the plant and its surrounding environment. The plant impedance is directly measured in a continuous manner, while, simultaneously surrounding environment parameters known to affect plant status, are monitored. This is done combining a new in-vivo direct measurement of the plant together with an embedded system using available sensor technology and a designated interface for continuous data acquisition. Furthermore, the next versions this system can be deployed as a field monitoring device, with simple adaptations

An in situ assessment of local adaptation in a calcifying polychaete from a shallow CO 2 vent system

Ocean acidification (OA) is likely to exert selective pressure on natural populations. Our ability to predict which marine species will adapt to OA and what underlies this adaptive potential is of high conservation and resource management priority. Using a naturally low-pH vent site in the Mediterranean Sea (Castello Aragonese, Ischia) mirroring projected future OA conditions, we carried out a reciprocal transplant experiment to investigate the relative importance of phenotypic plasticity and local adaptation in two populations of the sessile, calcifying polychaete Simplaria sp. (Annelida, Serpulidae, Spirorbinae): one residing in low pH and the other from a nearby ambient (i.e. high) pH site. We measured a suite of fitness-related traits (i.e. survival, reproductive output, maturation, population growth) and tube growth rates in laboratory-bred F2 generation individuals from both populations reciprocally transplanted back into both ambient and low-pH in situ habitats. Both populations showed lower expression in all traits, but increased tube growth rates, when exposed to low-pH compared with high-pH conditions, regardless of their site of origin suggesting that local adaptation to low-pH conditions has not occurred. We also found comparable levels of plasticity in the two populations investigated, suggesting no influence of long-term exposure to low pH on the ability of populations to adjust their phenotype. Despite high variation in trait values among sites and the relatively extreme conditions at the low pH site (pH < 7.36), response trends were consistent across traits. Hence, our data suggest that, for Simplaria and possibly other calcifiers, neither local adaptations nor sufficient phenotypic plasticity levels appear to suffice in order to compensate for the negative impacts of OA on long-term survival. Our work also emphasizes the utility of field experiments in natural environments subjected to high level of pCO2 for elucidating the potential for adaptation to future scenarios of OA

SN 2016coi (ASASSN-16fp): an energetic H-stripped core-collapse supernova from a massive stellar progenitor with large mass loss

We present comprehensive observations and analysis of the energetic H-stripped SN 2016coi (a.k.a. ASASSN-16fp), spanning the $\gamma$-ray through optical and radio wavelengths, acquired within the first hours to $\sim$420 days post explosion. Our campaign confirms the identification of He in the SN ejecta, which we interpret to be caused by a larger mixing of Ni into the outer ejecta layers. From the modeling of the broad bolometric light curve we derive a large ejecta mass to kinetic energy ratio ($M_{\rm{ej}}\sim 4-7\,\rm{M_{\odot}}$, $E_{\rm{k}}\sim 7-8\times 10^{51}\,\rm{erg}$). The small [\ion{Ca}{ii}] \lam\lam7291,7324 to [\ion{O}{i}] \lam\lam6300,6364 ratio ($\sim$0.2) observed in our late-time optical spectra is suggestive of a large progenitor core mass at the time of collapse. We find that SN 2016coi is a luminous source of X-rays ($L_{X}>10^{39}\,\rm{erg\,s^{-1}}$ in the first $\sim100$ days post explosion) and radio emission ($L_{8.5\,GHz}\sim7\times 10^{27}\,\rm{erg\,s^{-1}Hz^{-1}}$ at peak). These values are in line with those of relativistic SNe (2009bb, 2012ap). However, for SN 2016coi we infer substantial pre-explosion progenitor mass-loss with rate $\dot M \sim (1-2)\times 10^{-4}\,\rm{M_{\odot}yr^{-1}}$ and a sub-relativistic shock velocity $v_{sh}\sim0.15c$, in stark contrast with relativistic SNe and similar to normal SNe. Finally, we find no evidence for a SN-associated shock breakout $\gamma$-ray pulse with energy $E_{\gamma}>2\times 10^{46}\,\rm{erg}$. While we cannot exclude the presence of a companion in a binary system, taken together, our findings are consistent with a massive single star progenitor that experienced large mass loss in the years leading up to core-collapse, but was unable to achieve complete stripping of its outer layers before explosion.Comment: Submitted to ApJ. Main text: 21 pages; Appendix: 15 pages; 12 figure

Live Wire - A Low-Complexity Body Channel Communication System for Landmark Identification

This paper presents a robust simplex Body Channel Communication (BCC) system aimed at providing an interactive infrastructure solution for visually impaired people. Compared to existing BCC solutions, it provides high versatility, weara- bility and installability in an environment in a low complexity hardware-software solution. It operates with a ground referred transmitter (TX) and it is based on an asynchronous thresh- old receiver (RX) architecture. Synchronization, demodulation and packetizing and threshold control are completely software defined and implemented using MicroPython. The RX includes Bluetooth® (BT) radio connectivity and a cell-phone application provides push text-to-speech notifications to a smartphone. The hardware achieves a Packet Error Rate (PER) of ∼0.1 at 550 kHz pulse center frequency, Synchronized-On Off Keying (S- OOK) modulation and 1 kbps data rate, for an average current consumption of 44mA

Calophyllum brasiliense

Calophyllum brasiliense is a plant from the Brazilian rain forests and has been used in folk medicine for the treatment of various diseases, including leishmaniasis. This infectious disease depends on the Leishmania sp. and the host immune response. C. brasiliense antileishmanial activity is well known, but the effects on immune response remain to be investigated. This study showed the leishmanicidal and immunomodulatory effects of a 30 μg/mL of hydroalcoholic extract of C. brasiliense in murine macrophages before and after Leishmania (Leishmania) amazonensis infection. The semiquantitative cytokine RNA expression was determined by RT-PCR and the anti-Leishmania activity was measured by infection index (IF). Hydroalcoholic extract of C. brasiliense reduced more than 95% of IF when used before and after Leishmania infection, with 3 and 24 h of treatment (p<0.05). C. brasiliense inhibited or reduced significantly (p<0.05) the TNF-α, IL-1β, IL-18, and IL-10 mRNA expression. The antileishmanial and anti-inflammatory effects showed the potential of C. brasiliense as an alternative therapy for leishmaniasis and it must be investigated